Functional Testing and Quality of Life in Glaucoma

青光眼的功能测试和生活质量

基本信息

批准号：
10734431
负责人：
Stuart Gardiner
金额：
$ 62.8万
依托单位：
LEGACY EMANUEL HOSPITAL AND HEALTH CENTER
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-30 至 2027-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10734431
关键词：
Activities of Daily Living Affect Blindness Caring Cellular Phone Central Scotomas Clinic Clinical Clinical Management Clinical Trials Consumption Contrast Sensitivity Custom Data Devices Disease Electronics Equilibrium Eye Fall prevention Glaucoma Goals Health Hospitalization Impairment Individual Light Light Adaptations Lighting Location Longitudinal Studies Measurement Measures Medical Motivation National Eye Institute Ocular Hypertension Outcome Measure Participant Patient Care Patient Outcomes Assessments Patient Self-Report Patient-Focused Outcomes Patients Pattern Perimetry Peripheral Persons Quality of life Questionnaires Reporting Research Risk Scotoma Severities Severity of illness Tablet Computer Tablets Testing Time Trabeculectomy Vision Visit Visual Visual Fields Visual System Work Writing clinical care equilibration disorder experience fall risk falls functional loss hypertension treatment improved indexing individual patient medication compliance novel patient oriented personalized medicine preventive intervention prospective rate of change research clinical testing treatment adherence visual search

项目摘要

Project Summary / Abstract The goal of clinical management in eye care is to protect patients’ vision and consequent quality of life. Yet, the impact of vision loss on an individual’s quality of life depends not only on its severity, but also on its location within the visual field. Some tasks are predominantly impacted by central visual field loss, while others rely more on differing regions of the peripheral visual field. Thus, two individuals with the same disease severity could have very different experiences of that loss. This is particularly true for glaucoma, which causes localized loss in locations that can differ greatly between individuals. In this project, we will determine the regions of the visual field that most influence different aspects of quality of life. We will derive quantitative metrics of the likely real- world effects of an individual patient’s visual field defect that can be obtained without relying on time-consuming and variable questionnaires. These patient-centered metrics can aid clinicians in prioritizing care and choosing appropriate management strategies; and in explaining to an individual patient what the likely consequences are of their disease, both as motivation to maintain medication adherence and so that they can make necessary adjustments to their activities of daily living. In Aim 1, we will derive indices predicting the effect of an individual’s visual field loss on different patient-reported outcome measures, by parameterizing results from clinical standard automated perimetry, to maximize correlations with results of patient questionnaires from four large studies of ocular hypertension and glaucoma. In Aim 2, we will use similar analyses to predict the impact on visual search as measured by a custom-written test, performed on a tablet computer in glaucoma clinic waiting rooms and testing rooms. In Aim 3, we will predict the impact of an individual’s visual field loss on the visual contribution to balance and subsequent risk of falling, using objective measurements of balance in both high and low ambient light settings. Overall, the project will provide substantial advances in our understanding of the effects of localized visual field loss as caused by glaucoma, and provide invaluable new information for clinicians and patients.

项目概要/摘要眼保健临床管理的目标是保护患者的视力和随之而来的生活质量。视力丧失对个人生活质量的影响不仅取决于其严重程度，还取决于其位置一些任务主要受中央视野丧失的影响，而另一些任务则更多地依赖于中央视野丧失。因此，具有相同疾病严重程度的两个人可能具有相同的疾病严重程度。对于青光眼来说尤其如此，它会导致局部视力丧失。在这个项目中，我们将确定视觉区域。我们将得出可能真实的定量指标。无需花费大量时间即可获得个体患者视野缺陷的世界影响这些以患者为中心的指标可以帮助上级确定护理的优先顺序和选择。适当的管理策略；以及向个别患者解释可能的后果是什么的疾病，既作为维持药物依从性的动力，也使他们能够采取必要的措施在目标 1 中，我们将得出预测个人的影响的指数。通过参数化临床标准的结果，评估不同患者报告的结果测量的视野损失自动视野检查，以最大限度地提高与四项大型研究的患者调查问卷结果的相关性在目标 2 中，我们将使用类似的分析来预测对视觉搜索的影响。通过在青光眼诊所候诊室的平板电脑上进行的定制测试进行测量，在目标 3 中，我们将预测个人视野丧失对视觉贡献的影响。平衡和随后跌倒的风险，使用高和低环境中的平衡客观测量总体而言，该项目将极大地促进我们对局部化影响的理解。青光眼引起的视野丧失，为新人和患者提供宝贵的新信息。