Drinking water contaminants and fetal loss in Northern California

北加州的饮用水污染物和胎儿丢失

• 批准号: 10727706
• 负责人: Dana E Goin
• 金额: $ 18.6万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-10 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10727706
• 关键词: Address; Affect; Arsenic; Benchmarking; Benzene; Birth; Birth Records; Blood; California; Characteristics; Chemicals; Climate; Clinic Visits; Cohort Studies; Collaborations; Communities; Computerized Medical Record; Data; Data Sources; Droughts; Education; Electronic Health Record; Ensure; Environmental Hazards; Ethnic Origin; Exclusion; Exposure to; Fetal health; Fetus; General Population; Gestational Age; Goals; Health; Health Status; Heavy Metals; Hormonal; Household; Human Rights; Immunologics; Incidence; Individual; Intervention; Knowledge; Lead; Link; Literature; Live Birth; Manganese; Maternal Health; Metals; Monitor; National Institute of Child Health and Human Development; National Institute of Environmental Health Sciences; Nitrates; Occupational Exposure; Outcome; Overlapping Genes; Participant; Persons; Policy Maker; Population; Population Heterogeneity; Pregnancy; Pregnancy Complications; Pregnancy loss; Prenatal care; Prevalence; Prevention; Public Health; Race; Recording of previous events; Records; Regulation; Reproductive Health; Research; Research Personnel; Risk; Risk Reduction; Socioeconomic Status; Spontaneous abortion; System; Time; Toxicogenomics; United States; Universities; Uranium; Vanadium; Visit; Water; Water Pollutants; Water Supply; Wildfire; Work; adverse birth outcomes; chromium hexavalent ion; climate change; cohort; contaminated water; density; drinking water; environmental justice; experience; fetal loss; health disparity; health goals; improved; marginalized population; novel; population health; pregnant; racial disparity; socioeconomics; stillbirth; water quality; water testing

PROJECT SUMMARY/ABSTRACT The objective of this R03 proposal is to characterize the rates of miscarriage and stillbirth by gestational week in a Northern California population, and to evaluate whether climate change-sensitive drinking water contaminants increase rates of miscarriage and stillbirth. We also aim to estimate the effects of a hypothetical intervention of reducing water contaminant levels on risk of fetal loss. The relationships between drinking water contaminants and risks of miscarriage and stillbirth have not been investigated in California since the early 1980s. As climate change threatens the quality of drinking water in the state, it is important to better understand how climate-sensitive drinking water contaminants affect reproductive health. There is a significant gap in research on environmental determinants of fetal loss at a population level. This is likely due to the challenges in studying early fetal loss, as existing data sources have difficulty capturing miscarriage. However, electronic health record data can help us improve our knowledge of fetal loss between 10 and 20 weeks of gestation, when many pregnant people have received a prenatal care visit but whose pregnancies would not be captured in birth records. We propose to use Sutter Health’s electronic medical records to identify pregnancies, and link participants to community water system boundaries using residential address at each clinic visit. We will then assign water contaminant levels based on the annual average contaminant levels collected from public water monitoring information at the water system level in California. The goals of this project are to 1) characterize the rate of fetal loss in a diverse California cohort, 2) evaluate the individual and mixture effects of climate-sensitive water contaminants on rates of fetal loss, and 3) assess whether reducing all water contaminants to their 50th percentiles observed in the study cohort reduces the risk of fetal loss. The research plan is supported by a strong team of investigators from UCSF, Sutter Health, UC Berkeley, and Columbia University. The investigators have a strong history of collaboration and experience working with electronic health records. They bring significant expertise in reproductive health, drinking water contaminants, climate change, and environmental justice. This research addresses a significant gap in the literature and aligns with both NIEHS’s goal to generate evidence that can be used by policymakers to improve population health, and NICHD’s goals to understand contributors to pregnancy loss and to help identify targets for effective prevention of health disparities.

项目概要/摘要 该 R03 提案的目标是按孕周描述流产率和死产率 在北加州人口中，并评估气候变化是否对饮用水敏感 我们还旨在估计假设的影响。 降低水污染物水平与胎儿丢失风险之间的关系的干预措施。 自早期以来，加利福尼亚州就没有对污染物以及流产和死产的风险进行调查。 20 世纪 80 年代，气候变化威胁着该州的饮用水质量，因此必须采取更好的措施。 了解气候敏感的饮用水污染物如何影响生殖健康。 在人口层面上，关于胎儿丢失的环境决定因素的研究存在显着差距。 可能是由于研究早期胎儿丢失的挑战，因为现有数据源难以捕获 然而，电子健康记录数据可以帮助我们提高对流产之间胎儿丢失的了解。 妊娠 10 周和 20 周，许多孕妇接受了产前检查，但其 怀孕不会记录在出生记录中。 我们建议使用 Sutter Health 的电子病历来识别怀孕情况，并将参与者链接到 每次就诊时，我们都会使用居住地址来分配社区供水系统边界。 污染物水平基于公共水监测收集的年平均污染物水平 该项目的目标是 1) 描述加州供水系统的信息。 加州不同人群中的胎儿丢失，2) 评估气候敏感水的个体和混合物影响 污染物对胎儿流失率的影响，以及 3) 评估是否将所有水污染物减少到 50% 研究队列中观察到的百分位数降低了胎儿流产的风险。 该研究计划得到了来自加州大学旧金山分校、萨特健康中心、加州大学伯克利分校和加州大学伯克利分校的强大研究团队的支持。 研究人员与哥伦比亚大学有着悠久的合作历史和工作经验。 他们带来了生殖健康、饮用水污染物、 气候变化和环境正义。 这项研究填补了文献中的一个重大空白，并且符合 NIEHS 的目标： 政策制定者可以用来改善人口健康的证据，以及 NICHD 的目标来了解 造成妊娠损失的因素，并帮助确定有效预防健康差异的目标。