Military exposures and ALS in a large veteran population

大量退伍军人中的军事暴露和 ALS

• 批准号: 10701049
• 负责人: Marc G Weisskopf
• 金额: $ 43.02万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-30 至 2025-09-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10701049
• 关键词: Military; exposures; ALS; large; veteran

Project Summary/Abstract We propose to study the relation between military branch, occupation, deployment, and traumatic brain injury, as well as use of statins, and amyotrophic lateral sclerosis (ALS) incidence and survival using a new extremely large database that has linked both Department of Defense (DOD) and Veterans Administration (VA) data collected well before the onset of ALS. We will also explore whether use of statins protects against any adverse association with other military exposures. We will conduct a case-control study nested within the joint DOD-VA DaVINCI database of over 4 million US military veterans. We anticipate over 14,000 ALS cases and will match each on age and sex to 10 randomly selected controls. Military data includes aspects of military service like branch of service, military occupation, deployment, as well as demographic information and health data. In particular, it includes data on traumatic brain injury—captured both in theater (i.e. in the conflict environment) and elsewhere. VA data captures medical history of those service members who get health care at VA sites after their service. These data allow us to identify cases of ALS as well as use of medications such as use of statins. By nesting this study within large joint DOD-VA database, we have a unique setting that will allow us for the first time to assess the relation between key military exposures and ALS in an unprecedented way. Our hypothesis is that the increased risk of ALS frequently seen among those who served in the military is driven by specific exposures that are not randomly distributed among service members, but rather likely are selectively experienced by those in certain jobs or who are deployed (possibly varying by deployment location). Our study will help refine our understanding of what those factors could be.

项目摘要/摘要 我们建议研究军事分支，占领，部署和创伤性大脑之间的关系 损伤以及他汀类药物的使用以及肌萎缩性侧索硬化症（ALS）事件和使用新的生存 与国防部（DOD）和退伍军人管理部（VA）联系在一起的非常大的数据库 数据在ALS发作之前收集。我们还将探索他汀类药物的使用是否可以保护任何 与其他军事暴露的不利联系。我们将进行嵌套在关节内的病例对照研究 多达400万美国退伍军人的Dod-Va Davinci数据库。我们预计有14,000多个ALS案件和 每个年龄和性别都将与10个随机选择的对照匹配。军事数据包括军事的各个方面 服务等服务分支，军事职业，部署以及人口信息和健康 数据。特别是，它包括有关脑部损伤的数据 - 在剧院中都被捕获（即在冲突中 环境）和其他地方。 VA数据捕获了获得医疗保健的服务成员的病史 在他们服务后在VA网站上。这些数据使我们能够确定ALS病例以及使用此类药物 作为统计的使用。通过将这项研究嵌套在大型DOD-VA数据库中，我们有一个独特的设置 允许我们第一次评估主要的军事暴露与ALS之间的关系 方式。我们的假设是，在军队中服役的人中经常出现ALS的风险增加 是由不是在服务成员中随机分配的特定暴露驱动的，但很可能是 在某些工作或部署的人（可能随部署位置而变化）的选择性上。 我们的研究将有助于完善我们对这些因素可能是什么的理解。