Military exposures and ALS in a large veteran population

大量退伍军人中的军事暴露和 ALS

• 批准号: 10701049
• 负责人: Marc G Weisskopf
• 金额: $ 43.02万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-30 至 2025-09-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10701049
• 关键词: Military; exposures; ALS; large; veteran

Project Summary/Abstract We propose to study the relation between military branch, occupation, deployment, and traumatic brain injury, as well as use of statins, and amyotrophic lateral sclerosis (ALS) incidence and survival using a new extremely large database that has linked both Department of Defense (DOD) and Veterans Administration (VA) data collected well before the onset of ALS. We will also explore whether use of statins protects against any adverse association with other military exposures. We will conduct a case-control study nested within the joint DOD-VA DaVINCI database of over 4 million US military veterans. We anticipate over 14,000 ALS cases and will match each on age and sex to 10 randomly selected controls. Military data includes aspects of military service like branch of service, military occupation, deployment, as well as demographic information and health data. In particular, it includes data on traumatic brain injury—captured both in theater (i.e. in the conflict environment) and elsewhere. VA data captures medical history of those service members who get health care at VA sites after their service. These data allow us to identify cases of ALS as well as use of medications such as use of statins. By nesting this study within large joint DOD-VA database, we have a unique setting that will allow us for the first time to assess the relation between key military exposures and ALS in an unprecedented way. Our hypothesis is that the increased risk of ALS frequently seen among those who served in the military is driven by specific exposures that are not randomly distributed among service members, but rather likely are selectively experienced by those in certain jobs or who are deployed (possibly varying by deployment location). Our study will help refine our understanding of what those factors could be.

项目概要/摘要 我们建议研究军事部门、职业、部署和脑外伤之间的关系 损伤、他汀类药物的使用以及肌萎缩侧索硬化症 (ALS) 的发病率和生存率 连接国防部 (DOD) 和退伍军人管理局 (VA) 的超大型数据库 我们还将探讨使用他汀类药物是否可以预防任何 ALS 发作之前收集的数据。 我们将在联合研究中进行病例对照研究。 DOD-VA DaVINCI 数据库包含超过 400 万美国退伍军人，我们预计将有超过 14,000 个 ALS 病例。 将根据年龄和性别将每个数据与 10 个随机选择的对照进行匹配，其中包括军事方面的数据。 服务，如军种、军事占领、部署以及人口信息和健康 特别是，它包括在战区（即在冲突中）捕获的创伤性脑损伤的数据。 VA 数据记录了接受医疗保健的军人的病史。 这些数据使我们能够识别 ALS 病例以及药物的使用情况。 通过将这项研究嵌套在国防部-VA 大型联合数据库中，我们有一个独特的设置，将 让我们第一次以前所未有的方式评估关键军事暴露与 ALS 之间的关系 我们的假设是，ALS 风险增加常见于军队服役人员。 是由特定的风险驱动的，这些风险不是随机分布在服务成员之间的，而是很可能是 由从事某些工作或被部署的人员选择性地经历（可能因部署地点而异）。 我们的研究将有助于加深我们对这些因素的理解。