Developmental Research Program

发展研究计划

• 批准号: 10684289
• 负责人: GEROLD BEPLER
• 金额: $ 8.12万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-20 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10684289
• 关键词: Advanced Malignant Neoplasm; African American; African American population; Area; Award; Cities; Clinical; Collaborations; Communication; Communities; Comprehensive Cancer Center; Development; Disease; Disparity; Early Diagnosis; Faculty; Fostering; Funding; Future; Goals; Grant; Health; Health Disparities Research; Human Resources; Incidence; Infrastructure; Intervention; Laboratories; Malignant Neoplasms; Mentors; Methodology; Methods; Mission; Monitor; Morbidity - disease rate; Patients; Pilot Projects; Population Sciences; Prevention; Process; Program Research Project Grants; Program Reviews; Recommendation; Research; Research Personnel; Research Project Grants; Research Support; Resources; Review Committee; Science; Stage at Diagnosis; Structure; Translating; Translational Research; Underrepresented Minority; United States; Universities; Writing; cancer health disparity; disparity reduction; human subject; innovation; meetings; mortality; novel; programs; racial disparity; recruit; sound; translational impact; translational potential; treatment response

Project Summary The primary goal of the Developmental Research Program (DRP) of this P20 application is to advance the cancer health disparities research mission at the Karmanos Cancer Institute (KCI) by developing innovative research projects that are scientifically sound and translatable. The DRP provides a unique opportunity for soliciting new research ideas and encourages development of cancer health disparities projects with high translational potential. These projects provide investigators with the resources to conduct high-impact translational research consistent with our P20 SPORE's objectives. The goals will be achieved through the following specific aims: 1) Solicitation of DRP proposals through a highly structured process by leveraging the existing administrative structure of the KCI; 2) Review applications for new and renewal projects by a DRP Review Committee, which will recommend up to two new applications and two renewal applications for funding to the Executive Committee (except for the first year, where two new projects will be supported); 3) Monitor and evaluate funded projects for progress and translational potential, and assess their potential to become full P50 “SPORE-ready” translational projects; and 4) Integrate DRP investigators into the SPORE community by requiring participation in monthly meetings and group communications, and by providing opportunities for expanded collaborations. We will utilize KCI's existing infrastructure for the DRP to meet the translational objectives of the P20 SPORE and leverage already established mechanisms to solicit applications. These mechanisms also serve to foster excellent science in cancer health disparities, recruit new faculty to areas of focus, mentor junior faculty, and encourage research collaborations. PIs of new and renewal DRP projects will be required to submit written summaries of research accomplishments to the DRP Committee after 10 months and present these at one of the monthly meetings of the Executive Committee comprised of the co-leaders of the SPORE projects and core directors. This meeting will be used to determine whether the DRP projects are sufficiently meritorious for consideration as full translational projects by the Internal Advisory Board, followed by the EAB and the P20 Cancer Action Council, as part of a future Detroit Cancer Health Disparities P50 SPORE application. This program will encourage participation from a broad range of investigators at KCI and Wayne State University by providing support for pilot projects with the potential to develop into impactful translational projects. It also encourages and facilitates the development of new research directions, methodologies, and collaborations. Importantly, KCI has committed to provide the required funds annually for the DRP to fund up to two new projects every year at a maximum of $50,000 per project per year (with the potential of renewal for up to two projects per year in years 2 and 3).

项目概要 该 P20 应用的发展研究计划 (DRP) 的主要目标是推进癌症研究 卡马诺斯癌症研究所 (KCI) 开展创新研究，开展健康差异研究任务 DRP 为征集新项目提供了独特的机会。 研究想法并鼓励开发具有高转化率的癌症健康差异项目 这些项目为研究人员提供了进行高影响力转化研究的资源。 与我们的 P20 SPORE 目标一致。这些目标将通过以下具体目标来实现：1) 利用现有行政资源，通过高度结构化的流程征求 DRP 建议 KCI 的结构； 2) 由 DRP 审查委员会审查新项目和更新项目的申请， 将向执行委员会推荐最多两份新申请和两份续展申请 （第一年除外，将支持两个新项目）； 3）监督和评估资助项目 进展和转化潜力，并评估其成为完全 P50“SPORE-ready”转化的潜力 4) 通过要求参与每月一次的活动，将 DRP 调查员纳入 SPORE 社区； 我们将利用会议和小组沟通，并​​提供扩大合作的机会。 KCI 现有的 DRP 基础设施可满足 P20 SPORE 的转化目标并发挥作用 已经建立的征集申请机制也有助于培养优秀人才。 癌症健康差异的科学，招募新的教师到重点领域，指导初级教师，并鼓励 新的和更新的 DRP 项目的 PI 需要提交书面摘要。 10 个月后向 DRP 委员会提交研究完成情况，并在每月一次的会议上展示这些成果 执行委员会会议由SPORE项目联合领导者和核心董事组成。 这次会议将用于确定 DRP 项目是否足够值得考虑 作为内部咨询委员会的全面转化项目，随后是 EAB 和 P20 癌症行动 理事会，作为未来底特律癌症健康差异 P50 SPORE 申请的一部分。 通过提供以下内容，鼓励 KCI 和韦恩州立大学的广泛研究人员参与 它还鼓励有潜力发展成有影响力的转化项目的试点项目。 并促进新的研究方向、方法和合作的发展。 承诺每年为 DRP 提供所需资金，以资助每年最多两个新项目 每个项目每年最多 50,000 美元（每年可续签最多两个项目） 2 和 3)。