Zinc, Mental Health and School Performance in Mexico

墨西哥的锌、心理健康和学校表现

• 批准号: 7233666
• 负责人: ARYEH DAVID STEIN
• 金额: $ 22.7万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-06-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7233666
• 关键词: Accounting; Address; Adolescent; Affect; Age; Anemia; Anthropometry; Anxiety; Attention; Biochemical; Blood; Caregivers; Child; Child Mental Health; Complement; Daily; Data Analyses; Developed Countries; Developing Countries; Dietary intake; Effectiveness; Emotional; Ensure; Environmental Impact; Environmental Risk Factor; Folate; Functional disorder; Goals; Health; Infection; International; Investigation; Iron; Knowledge; Light; Malnutrition; Measures; Mediating; Mental Depression; Mental Health; Mexico; Micronutrients; Numbers; Nutritional; Outcome; Parents; Performance; Placebos; Policies; Populations at Risk; Preventive; Psychopathology; Public Health; Randomized; Recruitment Activity; Reporting; Research; School-Age Population; Schools; Score; Stress; Supplementation; Symptoms; Testing; Universities; Vitamin A; Zinc; Zinc deficiency; burden of illness; cognitive function; comparison group; depressive symptoms; double-blind placebo controlled trial; environmental stressor; health application; health school performance; improved; indexing; nutrition; programs; psychologic; psychological outcomes; stressor; teacher

DESCRIPTION (provided by applicant): The current application is a revision of proposal 1 R01 MH067981-01 initially reviewed in October 2002. Mental health problems are a significant public health concern among children and adolescents. We will evaluate relationships among zinc, mental health, and school performance in school-age children through a collaborative effort between the Department of International Health of Emory University and the Instituto Nacional de Salud Publica in Mexico. The central hypothesis is that zinc supplementation will improve the mental health and school performance of children in a population at risk for zinc deficiency and with significant mental health problems. This hypothesis will be tested by conducting a randomized double-blinded, placebo-controlled trial in central Mexico. Children, ages 7 to 11 (n=744), will be recruited to participate in a baseline assessment, six months of daily supplementation with 10 mg zinc or placebo, and a post-supplementation assessment. Information will be obtained from the children, primary caregivers, and teachers. The mental health outcomes include symptoms of depression and anxiety; other outcomes include school performance and problems of poor attention and low activity levels. Information will be obtained on biochemical indices of zinc status and anthropometry, and on potential confounders such as sociodemographics, illness/infection, anemia, micronutrient status (vitamin A, iron, folate), dietary intake, psychological status of the caregiver, and environmental stressors. Data analysis will include group comparisons (intent-to-treat) after ensuring effectiveness of randomization, along with analyses controlling for effects of potential confounders, and exploration of baseline relationships and the effects of zinc in light of potential mediating and moderating variables. The overall goal of the proposed research is to understand better how specific nutritional deficiencies and environmental stressors influence children's mental health and school performance, and to contribute preventive, complementary approaches to addressing the growing mental health needs of children worldwide.

描述（由申请人提供）：当前申请是对 1 R01 MH067981-01 提案的修订，最初于 2002 年 10 月审查。心理健康问题是儿童和青少年中一个重要的公共卫生问题。我们将通过埃默里大学国际卫生系和墨西哥国家健康研究所之间的合作，评估学龄儿童的锌、心理健康和学校表现之间的关系。中心假设是，补充锌将改善存在缺锌风险和存在严重心理健康问题的人群中儿童的心理健康和学校表现。这一假设将通过在墨西哥中部进行一项随机双盲、安慰剂对照试验来检验。 7 至 11 岁的儿童 (n=744) 将被招募参加基线评估、为期六个月的每日补充 10 毫克锌或安慰剂以及补充后评估。将从儿童、主要看护者和教师处获取信息。心理健康结果包括抑郁和焦虑症状；其他结果包括学校表现以及注意力不集中和活动水平低的问题。将获得有关锌状况和人体测量的生化指标以及潜在混杂因素的信息，例如社会人口统计学、疾病/感染、贫血、微量营养素状况（维生素 A、铁、叶酸）、饮食摄入量、护理人员的心理状况和环境压力源。数据分析将包括确保随机化有效性后的组间比较（意向治疗），以及控制潜在混杂因素影响的分析，并根据潜在的中介和调节变量探索基线关系和锌的影响。拟议研究的总体目标是更好地了解特定的营养缺乏和环境压力因素如何影响儿童的心理健康和学校表现，并提供预防性、补充性方法来满足全世界儿童日益增长的心理健康需求。

项目成果

Randomized trial of the effect of zinc supplementation on the mental health of school-age children in Guatemala.

补充锌对危地马拉学龄儿童心理健康影响的随机试验。

• 发表时间: 2010-11
• 作者: DiGirolamo, Ann M;Ramirez;Wang, Meng;Flores;Martorell, Reynaldo;Neufeld, Lynnette M;Ramakrishnan, Usha;Sellen, Daniel;Black, Maureen M;Stein, Aryeh D
• 通讯作者: Stein, Aryeh D

Relative Validity of Three Food Frequency Questionnaires for Assessing Dietary Intakes of Guatemalan Schoolchildren.

用于评估危地马拉学童膳食摄入量的三种食物频率问卷的相对有效性。

• 发表时间: 2015
• 影响因子: 3.7
• 作者: Marcinkevage, Jessica;Mayén, Ana;Zuleta, Clara;DiGirolamo, Ann M;Stein, Aryeh D;Ramirez
• 通讯作者: Ramirez

Role of zinc in maternal and child mental health.

锌在孕产妇和儿童心理健康中的作用。

• 发表时间: 2009-03
• 作者: DiGirolamo, Ann M;Ramirez
• 通讯作者: Ramirez

Associations between serum C-reactive protein and serum zinc, ferritin, and copper in Guatemalan school children.

危地马拉学童血清 C 反应蛋白与血清锌、铁蛋白和铜之间的关联。

• 发表时间: 2012-08
• 影响因子: 3.9
• 作者: Bui, Vinh Q;Stein, Aryeh D;DiGirolamo, Ann M;Ramakrishnan, Usha;Flores;Ramirez;Grant, Frederick K;Villalpando, Salvador;Martorell, Reynaldo
• 通讯作者: Martorell, Reynaldo