Core B: Neuropathology Core

核心 B：神经病理学核心

• 批准号: 10684505
• 负责人: WILLIAM W SEELEY
• 金额: $ 18.47万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10684505
• 关键词: Address; Aging; Anatomy; Autopsy; Biological Markers; Brain; Brain Diseases; Clinical; Cognitive; Complex; Consensus; Custom; DNA; Data; Data Analytics; Databases; Diagnosis; Diagnostic; Disease; Emotional; Emotions; Faculty; Fellowship; Fostering; Frontotemporal Dementia; Future; Genes; Goals; Grouping; Growth; Health Insurance Portability and Accountability Act; Image; Indiana; International; Language; Methods; Molecular; Nerve Degeneration; Neurodegenerative Disorders; Neurologist; Neurology; Neuropsychology; Pathologic; Patients; Peripheral Blood Mononuclear Cell; Plasma; Play; Process; Public Health; Reporting; Research; Research Personnel; Role; Rotation; Running; Sampling; Scientist; Secure; Services; Source; Specimen; Spinal Cord; System; Time; Tissues; Training; Work; anatomic imaging; behavioral variant frontotemporal dementia; biomarker discovery; brain tissue; clinical conference; diagnostic biomarker; digital; experience; histological stains; improved; interest; meetings; member; neuroimaging; neuropathology; next generation; primary outcome; programs; prospective; protein aggregation; social; symposium

ABSTRACT Core B is a Neuropathology and Biomarker Core (NP Core) that plays a vital role in the UCSF FTD PPG. FTLD neuropathology has become increasingly exciting and complex in recent years, with major advances arising from work accomplished through this PPG. In this renewal application, we propose to continue to cultivate a world-class FTLD-oriented neurodegenerative disease brain bank at UCSF. The NP Core aims to: (1) Obtain CNS tissue for NP characterization and banking by performing timely autopsies on patients and healthy controls ascertained through the Clinical Core; (2) Analyze specimens and document NP diagnoses by dissecting a standard set of 23 tissue blocks for routine histological staining and systematic immunohistochemical characterization, resulting in semi-quantitative and quantitative assessments; (3) Enter NP findings into a comprehensive research-oriented database; (4) Bank CNS tissues, blood, plasma, and CSF, analyze CSF for putative diagnostic biomarkers, and distribute biospecimens to qualified investigators; (5) Engage with PPG collaborators in conducting FTLD clinico-pathological research by meeting regularly with PPG Project leaders who rely on NP Core data; and (6) Train the next generation of neuropathology leaders and clinical scientists grounded in neuropathology principles and methods by holding consensus and clinico- pathological conferencesThese core functions will support the aims of Projects 3 (Emotions), 4 (Clinical criteria), and 7 (Language) by providing final neuropathological diagnoses that serve as primary outcomes or grouping variables as well as semi-quantitative and/or quantitative regional pathological data. Moreover, the NP Core will help to further develop a unique bank of specially handled CNS tissues (brain, spinal cord, and CSF) for ongoing and future FTLD molecular, translational, clinicopathological, and biomarker discovery research.

抽象的 核心B是一种神经病理学和生物标志物核心（NP核心），在UCSF FTD PPG中起着至关重要的作用。 ftld 近年来，神经病理学变得越来越令人兴奋和复杂，主要进步 从通过此PPG完成的工作。在此续签应用中，我们建议继续培养 UCSF的世界一流的面向FTLD的神经退行性疾病脑库。 NP核心的目的是：（1）获得 通过对患者进行及时尸检和健康的CNS组织，用于NP表征和银行业务 控制通过临床核心确定； （2）通过 解剖一组标准的23个组织块，以进行常规的组织学染色和系统 免疫组织化学表征，导致半定量和定量评估； （3）输入 NP的发现成一个全面的面向研究的数据库； （4）银行CNS组织，血液，血浆和CSF， 分析CSF的推定诊断生物标志物，并向合格的研究人员分发生物测量； （5） 与PPG合作者合作进行FTLD临床病理学研究，定期与 依靠NP核心数据的PPG项目负责人； （6）训练下一代神经病理学领导者 以及通过持有共识和临床的神经病理学原理和方法基础的临床科学家 病理会议核心功能将支持项目3的目标（情感），4（临床 标准）和7（语言）通过提供最终的神经病理学诊断，这些诊断是主要结果或 分组变量以及半定量和/或定量区域病理数据。而且， NP Core将有助于进一步开发一组独特的CNS组织（大脑，脊髓和 CSF）用于持续和未来的FTLD分子，转化，临床病理和生物标志物发现 研究。