The Pacific Ocean Native Observational (PONO) Health Legacy Study

太平洋原住民观测 (PONO) 健康遗产研究

• 批准号: 10724217
• 负责人: Marjorie K. Leimomi Mala Mau
• 金额: $ 58.37万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-15 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10724217
• 关键词: Address; Age; Age Years; Age of Onset; Asian Americans; Behavior; Behavioral; Biological; Biological Factors; Blood; Body mass index; Cardiopulmonary; Cardiovascular Diseases; Cause of Death; Chronic Disease; Chronic Obstructive Pulmonary Disease; Clinic Visits; Clinical; Clinical Research; Cohort Studies; Collaborations; Communities; Complex; Data; Data Reporting; Diabetes Mellitus; Diet; Disease; Disease Outcome; Disparity; Electronic Health Record; Enrollment; Environmental Exposure; Enzyme-Linked Immunosorbent Assay; Epidemiology; Ethnic Origin; Family; Feces; Federally Qualified Health Center; Future Generations; Generations; Genetic; Glycosylated hemoglobin A; Goals; Hawaii; Health; Health Disparities Research; Health behavior; Heterogeneity; Home; Household; Immunologics; Incidence; Individual; Inflammation; Institutional Racism; Intervention Studies; Investments; Knowledge; Life Style; Longevity; Longitudinal Studies; Measures; Mediating; Medical; Metabolic; Metabolic Diseases; Methodology; Native Hawaiian; Native Hawaiian or Other Pacific Islander; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Observational Study; Outcome; Outcome Measure; Pacific Islander; Pacific Ocean; Participant; Periodicals; Persons; Phase; Physical activity; Population; Prevalence; Process; Protocols documentation; Pulmonary Heart Disease; Questionnaires; Race; Recording of previous events; Research; Research Design; Research Personnel; Resources; Risk; Risk Factors; Sample Size; Severities; Smoking; Social Network; Technology; Testing; Time; Tissues; Trauma; Universities; Urine; Variant; Visceral; Visit; Work; age group; biobank; blood-based biomarker; cohort; community engagement; community organizations; data standards; diabetes risk; early onset; epigenomics; ethnic diversity; follow-up; gene environment interaction; health disparity; health inequalities; immune function; innovation; microbiome; mortality; multi-racial; novel; population based; prospective; psychosocial; racial population; recruit; resilience factor; sample collection; sex; social; social health determinants; socioenvironmental factor

PROJECT SUMMARY Hawai‘i is the most ethnically diverse state in the US. Native Hawaiians (NH), Pacific Islanders (PI) and Asian Americans (AsA) account for nearly 70% of the state’s population & it is home to >50% of all NHPI in the US. This UG3/UH3 proposal will establish a new prospective, multi-generational cohort to investigate cardiopulmonary & metabolic (CPM) health among NH & Micronesian PI in Hawai‘i. These 2 distinct, yet understudied, sub-populations have an excess burden of CPM disease outcomes. Diabetes mellitus (DM) occurs in 28% and preDM in 37% of NHPI (>20y.o.), suggesting >50% of NHPI have or are at-risk for DM. CVD mortality is 4-fold higher in NHPI with DM compared with nonDM. CVD mortality is the leading cause of death among NHPI. Despite decades of clinical & intervention studies among NHPI, CPM health inequities remain largely unchanged & is increasing among younger NH and PI people. Our proposal, the Pacific Ocean Native Observational (PONO) Health Legacy Study, will directly confront methodological challenges (i.e. racial aggregation, small sample size, etc.) of prior NHPI studies & will conduct innovative, technology-driven “populomics” approaches to change the course of CPM health disparities among NH & PI. Our approach builds on a strong interdisciplinary team of scientific & community-based leaders who bring decades of community, clinical, epidemiological & epigenomic expertise. We will work closely with the Coordinating Center to maximize the overall AsA-NHPI cohort’s ability to conduct studies of multiple hypotheses testing. Our specific aims (S.A.) are as follows: S.A.#1 (UG3): Establish a prospective, community-engaged, multi-generational population-based cohort study of 2,500 Native Hawaiians and Pacific Islanders in Hawai‘i. Our longstanding partnerships with clinical & community-based groups are primed & enthusiastic to recruit, retain & conduct standardized data & biological specimen collection that will invest in the health of future generations. S.A. #2 (UH3): Characterize the relationship of risk and resilience factors with clinical blood-based biomarkers of metabolic and immunologic function relevant to CPM conditions. Determine prevalence of CPM subclinical disease & conduct association studies of multi-level risk & resilience factors by CPM conditions. S.A. #3 (UH3): Assess the impact of CPM-associated risk and resilience factors on incident CPM- outcomes measured over time between Hawai‘i and continental populations of NH and PI in the AsA- NHPI cohort study. Determine incidence of CPM outcomes associated with multi-level risk/resilience factors & to compare data with relevant subpopulations in the overall AsANHPI cohort. The overall impact of the PONO study is its potential to transform health disparity research through novel “populomics” approaches in a representative population of AsANHPI in the US.

项目概要 夏威夷是美国种族最多元化的州，夏威夷原住民 (NH)、太平洋岛民 (PI) 和亚洲人。 美国人 (AsA) 占该州人口的近 70%，并且该州拥有超过 50% 的全美 NHPI。 该 UG3/UH3 提案将建立一个新的前瞻性、多代队列来研究 夏威夷 NH 和密克罗尼西亚 PI 的心肺和代谢 (CPM) 健康状况这两个截然不同。 研究不足，亚人群的 CPM 疾病结果负担过重。 20 岁以上的 NHPI 中 28% 发生糖尿病，37% 发生前期糖尿病，表明超过 50% 的 NHPI 患有糖尿病或有患糖尿病的风险。 与非糖尿病 CVD 死亡率相比，患有 DM 的 NHPI 的 CVD 死亡率高出 4 倍。 尽管对 NHPI 进行了数十年的临床和干预研究，但 CPM 健康不平等。 基本保持不变，并且在年轻的 NH 和 PI 人群中正在增加。我们的建议是太平洋。 本地观察（PONO）健康遗产研究将直接面临方法论挑战（即 先前 NHPI 研究的种族聚集、小样本量等）并将进行创新、技术驱动的研究 我们的方法建立了“大众组学”方法来改变 NH 和 PI 之间 CPM 健康差异的过程。 强大的跨学科团队由科学和社区领导者组成，他们带来了数十年的社区经验， 我们将与协调中心密切合作，以提供临床、流行病学和表观基因组学专业知识。 最大限度地提高 AsA-NHPI 队列的整体能力来进行多重假设检验的研究。 目标（S.A.）如下： S.A.#1 (UG3)：建立一个前瞻性的、社区参与的、基于多代人群的 由 2,500 名夏威夷原住民和太平洋岛民组成的队列研究 我们的长期合作伙伴关系。 与临床和社区团体合作，准备好并热衷于招募、保留和实施标准化 数据和生物样本收集将投资于子孙后代的健康。 S.A. #2 (UH3)：描述风险和恢复力因素与临床血液的关系 与 CPM 状况相关的代谢和免疫功能的生物标志物 确定 CPM 患病率。 CPM 亚临床疾病并通过 CPM 进行多层次风险和恢复因素的关联研究 状况。 S.A. #3 (UH3)：评估 CPM 相关风险和弹性因素对事件 CPM 的影响 随着时间的推移，在夏威夷州和夏威夷州的 NH 和 PI 大陆人口之间测量的结果 NHPI 队列研究确定与多级风险/弹性因素相关的 CPM 结果的发生率 将数据与整个 AsANHPI 队列中的相关亚群进行比较。 PONO 研究的总体影响在于其通过以下方式改变健康差异研究的潜力： 在美国 AsANHPI 代表性人群中采用新颖的“群体组学”方法。