Definition and Caregiver Appraisal of Paradoxical Lucidity in Dementia

痴呆症中矛盾清醒的定义和护理人员评估

基本信息

批准号：
10683504
负责人：
JOAN M. GRIFFIN
金额：
$ 40.69万
依托单位：
MAYO CLINIC ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-30 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10683504
关键词：
Address Advocacy Affect Age Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Anecdotes Awareness Behavior Bereavement Brain Health Registry Caregiver well-being Caregivers Case Study Cessation of life Characteristics Clinical Cognitive Communication Conflict (Psychology)Consensus Data Dementia Dementia caregivers Development Dimensions Disease Education Ensure Ethical Issues Event Family Family Caregiver Family member Future Geography Goals Grief reaction Health Impaired cognition Incidence Individual Internet Intervention Interview Knowledge Link Long-Term Care Longitudinal Surveys Measures Memory Methodology Methods Minnesota Mission Moods Nonprofit Organizations Outcome Outcome Study Pattern Persons Pharmaceutical Preparations Phase Prevalence Prognosis Registries Reporting Research Structure Surveys Testing Time Typology Universities Work advocacy organizations base care giving burden caregiver bereavement caregiver interventions caregiving clinical practice cognitive capacity demographics education resources epidemiology study evidence base experience innovation longitudinal analysis novel perceived stress psychoeducation response sex

项目摘要

PROJECT SUMMARY Alzheimer’s disease and related dementias are typically thought of in terms of progressive cognitive decline, and relatively little is known about episodes of lucidity that occur among people with dementia. Paradoxical lucidity is defined as spontaneous, relevant communication or connectedness in a person with dementia. Few studies have focused on paradoxical lucid episodes, and little is known about what may cause paradoxical lucidity, how common lucid events are, and how lucidity impacts family caregivers of persons with dementia. The broad goal of this study is to define paradoxical lucidity, determine the prevalence and predictors of paradoxical lucidity, and assess the impact that lucidity has on family caregivers. Our proposal will establish a definition of paradoxical lucidity based on survey data and interviews with caregivers, as well as input from a panel of clinical experts in Alzheimer’s disease and related dementias. Next, we will administer an online survey to 8,000 dementia caregivers across three time periods (baseline, 6-months, and 12-months) to measure how frequently paradoxical lucidity occurs across time. We will analyze survey data to establish what may predict paradoxical lucidity and how paradoxical lucidity is linked to caregiver well-being. The results of this work will help inform clinical practice, build capacity for Alzheimer’s Disease education and advocacy, and build knowledge on an understudied aspect of dementia.

项目概要阿尔茨海默病和相关痴呆症通常被认为是进行性衰退，对于痴呆症患者的清醒状态知之甚少。清醒被定义为痴呆症患者自发的、相关的沟通或联系。研究主要集中在自相矛盾的清醒发作上，而对于什么可能导致自相矛盾的清醒事件知之甚少。清醒度、清醒事件的常见程度以及清醒度如何影响痴呆症患者的家庭护理人员。这项研究的总体目标是定义矛盾清醒，确定自相矛盾的发生率和预测因素清醒度，并评估清醒度对家庭照顾者悖论的影响。根据调查数据和对护理人员的访谈以及来自专家的意见来定义矛盾的清醒度接下来，我们将管理一个在线的阿尔茨海默病和相关痴呆症临床专家小组。对三个时间段（基线、6 个月和 12 个月）的 8,000 名痴呆症护理人员进行的调查衡量一段时间内自相矛盾的清醒发生的频率我们将分析调查数据以确定什么。可以预测矛盾清醒度以及矛盾清醒度如何与护理人员的幸福感相关的结果。这项工作将有助于为临床实践提供信息，建设阿尔茨海默病教育和宣传的能力，以及建立有关痴呆症未被充分研究的方面的知识。