Knowledge Base and Portal

知识库和门户

基本信息

批准号：
10676276
负责人：
Lang Li
金额：
$ 96.46万
依托单位：
INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-10 至 2026-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10676276
关键词：
7alpha hydroxylase ABCB1 gene Academia Acceleration Active Learning Adult Affect American Animals Artificial Intelligence Birth Body Water CYP1A2 gene CYP2C19 gene CYP2C9 gene CYP2D6 gene CYP3A4 gene CYP3A5 gene Child Childhood Classification Clinical Research Clinical Trials Clinical Trials Design Collaborations Common Data Element Communities Cytochrome P450 Data Data Sources Dehydroepiandrosterone Sulfate Development Devices Disease Dose Drug Kinetics Drug Metabolic Detoxication Drug Receptors Drug toxicity Education Enzymes Excretory function Fathers Fetal Liver Fetus Glucuronosyltransferase Growth Human Indiana Industry Infant Isoenzymes Kidney Knowledge Knowledge Portal Lactation Literature Location Maternal Physiology Metabolism Modeling Ohio Ontology Pediatrics Performance Pharmaceutical Preparations Pharmacodynamics Pharmacoepidemiology Pharmacogenetics Pharmacogenomics Pharmacology Pharmacology and Toxicology Pharmacotherapy Phase Physiological Population Pregnancy Process Property Protein Isoforms Publishing Reporting Research Research Priority Resources Retinoids Sample Size Tablets Technology Teratogens Text Therapeutic Therapeutic Research Training Translational Research Tubular formation Universities Uridine Diphosphate Visualization software Woman Work absorption classification algorithm clinical investigation data access data curation data dissemination data mining data portal data sharing data visualization deep learning disability drug clearance drug development drug disposition drug distribution drug efficacy drug metabolism extracellular gender difference graphical user interface improved innovation knowledge base knowledgebase men neonate novel ontology development open source outreach pediatric patients pharmacometrics portability pregnant research and development response web portal

项目摘要

Summary (Knowledgebase and Portal Core) The Knowledgebase and Portal Core (KPC) of the Indiana University-Ohio State University Maternal and Pediatric Precision in Therapeutics Data, Model, Knowledge, and Research Coordination Center (IU-OSU MPRINT DMKRCC) will develop a knowledgebase and web portal of data and resources relating to maternal and pediatric therapeutics. The KPC will collaborate with Pharmacometrics and Clinical Trial Design Core, Real- World Evidence Core, and other collaborators to support common data elements and ontology development, knowledgebase construction, and web portal development. The Aims of the KPC will be 1) to develop common data elements and ontology for annotating pharmacology data in children and pregnant/lactating women, including those with disabilities; (2) Develop text classification algorithms to identify published literature in pediatric and pregnant/lactating women; (3) Integrate various data sources relating to pharmacokinetics, pharmacodynamics, pharmacogenetics, pediatric ontogeny and the physiological changes that occur with and around pregnancy and lactation that influence drug metabolism, distribution, and drug response; pharmacogenomics, pharmacometrics modeling; and drug toxicity and efficacy in maternal and pediatric populations; (4) Develop a data portal for knowledge data sharing and dissemination. The KPC will work with the MPRINT Hub Steering Committee to set research priorities and milestones and with the Outreach, Dissemination and Training Core to disseminate results and provide education on pharmacometric approaches applied to maternal and pediatric therapeutic research.

摘要（知识库和门户核心）印第安纳大学-俄亥俄州立大学妇产科知识库和门户核心 (KPC) 儿科精准治疗数据、模型、知识和研究协调中心 (IU-OSU MPRINT DMKRCC）将开发一个知识库和门户网站，其中包含与孕产妇相关的数据和资源和儿科治疗。 KPC 将与 Pharmacometrics and Clinical Trial Design Core、Real- World Evidence Core 和其他合作者支持通用数据元素和本体开发，知识库建设和门户网站开发。 KPC 的目标是 1) 发展共同用于注释儿童和孕妇/哺乳期妇女药理学数据的数据元素和本体，包括残疾人； (2) 开发文本分类算法来识别已发表的文献儿科和孕妇/哺乳期妇女； (3) 整合药代动力学相关的各种数据源，药效学、药物遗传学、儿科个体发育以及伴随和发生的生理变化妊娠期和哺乳期影响药物代谢、分布和药物反应的；药物基因组学、药物计量学建模；以及药物对母婴的毒性和疗效人口；（4）开发知识数据共享和传播的数据门户。 KPC 将与 MPRINT 中心指导委员会确定研究重点和里程碑，并通过外展活动，传播和培训核心，用于传播结果并提供药理学方法教育应用于母婴治疗研究。