Next-Gen Oncopathology Program

下一代肿瘤病理学计划

• 批准号: 10676213
• 负责人: ETHEL CESARMAN
• 金额: $ 36.18万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10676213
• 关键词: programs

The Next-Gen Oncopathology (NGO) program has the overall mission of training young diagnosticians to meet advances in our understanding of the mechanisms of cancer pathogenesis and new oncological interventional approaches thereby leading the field of pathology into the future. Specialized pathologists have been involved in cancer diagnostics by examining tissues and other specimens since at least the 19th century, and training in pathology has been incrementally structured and subspecialized. Pathology training programs traditionally teach residents to examine tissue under the microscope and analyze laboratory data for diagnosis, with pathology research being largely descriptive. This approach is no longer sufficient, and it is essential that we prepare pathologists to understand and apply advanced technologies to perform more precise and personalized diagnostics in addition to utilizing innovative and improved ways to conduct research and diagnose cancer. The Weill Cornell Department of Pathology and Laboratory Medicine has trained numerous outstanding pathologists in many subspecialty areas, but it is only with the use of an innovative approach incorporating a view towards the future that we will be able to produce leaders that will advance the field of cancer pathology. The NGO program takes a holistic and multidisciplinary approach, where all aspects of a cancer patient are considered, ranging from the tumors themselves, to in vitro and in vivo cancer models, to changes in the patients’ blood and microbial infections. Thus, trainees in both Anatomic and Clinical Pathology (i.e. Laboratory Medicine) will be included, which will be individuals with MD or MD/PhD degrees doing a Pathology Residency or Fellowship, or trainees with PhD degrees doing a clinical fellowship in Laboratory Medicine, who are committed to an academic career that includes cancer research. Our trainees will gain expertise and depth by spending two years in a research laboratory working in one or more of the following major themes: 1) molecular diagnosis and cellular therapies, 2) cancer pathobiology, 3) advanced imaging and 4) tumor microenvironment. The foundational principles of the NGO program will be to ensure that all the pathology projects relate to the study of cancer patient samples as well as the comparative pathology of cancer models. Overarching methodologies that will support all of the projects are: i) biostatistics and data science, ii) machine learning and artificial intelligence, and iii) genomics, epigenomics, proteomics and metabolomics. Faculty in the program have expertise in the major themes and specific methodologies, which will allow for the teaching of foundational skills as well as a highly customized educational plan. This will be accomplished by the establishment of a mandatory NGO Course as well as additional course requirements on data science and career development, which will allow trainees flexibility to design a personalized curriculum with their mentoring committee. We will also leverage the Meyer Cancer Center and the Weill Cornell Clinical and Translational Science Center (CTSC) resources to educate the next generation of pathologists working on cancer.

下一代肿瘤病理学 (NGO) 计划的总体使命是培训年轻的诊断医生以满足 我们对癌症发病机制和新肿瘤介入治疗的理解取得了进展 从而引领病理学领域走向未来。专业病理学家的参与。 至少自 19 世纪以来，通过检查组织和其他标本进行癌症诊断，并接受培训 病理学培训项目传统上已逐渐结构化和细分化。 居民在显微镜下检查组织并分析实验室数据以进行病理学诊断 研究主要是描述性的，这种方法已经不够了，我们必须做好准备。 病理学家了解并应用先进技术来进行更精确和个性化的治疗 除了利用创新和改进的方法进行研究和诊断癌症之外，还可以进行诊断。 威尔康奈尔病理学与检验医学系培养了众多优秀的病理学家 在许多子专业领域，但只有使用创新方法，并考虑到 未来我们将能够培养出推动癌症病理学领域发展的领导者。 计划采用整体和多学科的方法，考虑癌症患者的各个方面， 从肿瘤本身到体外和体内癌症模型，再到患者血液和血液的变化 因此，解剖学和临床病理学（即检验医学）的学员将 包括，具有医学博士或医学博士/博士学位的个人，从事病理学住院医师或研究金，或 拥有博士学位的学员，从事检验医学临床研究，致力于学术研究 我们的学员将通过两年的学习获得专业知识和深度。 研究实验室致力于以下一个或多个主要主题：1）分子诊断和细胞 疗法，2）癌症病理学，3）先进成像和4）肿瘤微环境。 非政府组织计划的原则是确保所有病理学项目都与癌症研究相关 患者样本以及癌症模型的比较病理学。 支持所有项目是：i) 生物统计学和数据科学，ii) 机器学习和人工智能，以及 iii) 基因组学、表观基因组学、蛋白质组学和代谢组学专业的教师拥有该专业的专业知识。 主题和具体方法，这将允许教授基础技能以及高度 这将通过建立强制性非政府组织课程来完成。 以及关于数据科学和职业发展的额外课程要求，这将使学员能够 我们还将利用迈耶的指导委员会灵活地设计个性化课程。 癌症中心和威尔康奈尔临床和转化科学中心 (CTSC) 提供资源来教育 下一代研究癌症的病理学家。