Biostatistics & Informatics Shared Resource

生物统计学

• 批准号: 10671737
• 负责人: Byron J. Gajewski
• 金额: $ 30.58万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-11 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10671737
• 关键词: Address; Animals; Applications Grants; Area; Basic Science; Bioinformatics; Biometry; Budgets; Cancer Biology; Cancer Center; Cancer Center Support Grant; Cancer Control; Clinical; Clinical Research; Clinical Trials; Collaborations; Computer Analysis; Computer software; Custom; Data; Data Analyses; Data Collection; Data Reporting; Data Science; Data Set; Databases; Development; Doctor of Philosophy; Education; Educational workshop; Experimental Designs; Faculty; Frequencies; Funding; Genetic; Genomics; Goals; Grant; Human; Informatics; Information Systems; Investigational Therapies; Investments; Kansas; Leadership; Maintenance; Malignant Neoplasms; Methodology; Methods; Molecular; Outcome; Play; Postdoctoral Fellow; Quality Control; Reproducibility; Research; Research Activity; Research Design; Research Personnel; Research Project Grants; Research Support; Resource Informatics; Resource Sharing; Resources; Role; Services; Standardization; Statistical Data Interpretation; Students; System; Technology; Training; Translational Research; Universities; Visualization; Work; anticancer research; cancer prevention; complex data; cost effective; cost effectiveness; data cleaning; data management; design; drug discovery; electronic data; high dimensionality; improved; informatics shared resource; interest; member; novel; pre-clinical; programs; research study; skills; statistics; synergism; tool; trend

BIOSTATISTICS AND INFORMATICS SHARED RESOURCE (BISR): ABSTRACT The Biostatistics and Informatics Shared Resource (BISR) plays an essential role in the research activities of The University of Kansas Cancer Center (KUCC) by supporting the data science needs of KUCC investigators. The BISR is co-led by Byron Gajewski (CPC), PhD, and Devin Koestler (CB), PhD, both accomplished biostatisticians with a long-standing commitment to cross-disciplinary collaborations. The BISR includes 19 faculty members with specialized cancer biostatistics research expertise, 13 technical support staff and postdoctoral fellows, and three administrative staff members who provide additional technical and administrative expertise, adding efficiency to the resource. The BISR assists KUCC investigators by providing guidance and direction in study design, statistical oversight and analyses, clinical research informatics and data management, electronic data collection, bioinformatics, complex data set (statistical ‘omics) analysis, and investigator-initiated clinical trials. The BISR consists of faculty and staff whose diverse expertise and skill sets span the areas of biostatistics, bioinformatics, and informatics. The considerable overlap between these three areas allows researchers to work with a single shared resource for their data collection, analytics, and statistical analysis needs. The synergy between the areas that encompass “data science” enables the BISR to support a wide range of quality services in a timely and cost-effective manner. To support the research activities of KUCC members, the specific aims of this resource are to: 1) provide study design and statistical support and expertise; 2) provide bioinformatics and statistical genetics support and expertise; 3) provide informatics expertise for data collection and management, as well as develop and support ongoing research enabling technologies, platforms, and tools; and 4) educate students, fellows and faculty members of KUCC on data science, reproducible research ideas, and methods used in cancer research. From 2016-2020, the BISR supported 69, 60, 85, 80, and 78 KUCC members respectively. In 2020, the breakdown was 18, 33, and 27 members from Cancer Biology, Cancer Prevention and Control, and Drug Discovery, Delivery and Experimental Therapeutics, respectively, on 89 grant applications (submissions and resubmissions) and 161 projects (ongoing grants, IITs, and other projects). In addition, the BISR supported 31 non-member cancer researchers in 2020. For all cancer-related projects, the BISR supported 340 grant applications plus projects in 2020. In 2021, CCSG funding accounts for ~10% of the BISR budget, with an annual direct support return on investment of approximately $0.6M dollars in external funding to support BISR faculty and staff (31% of BISR support).

生物统计和信息学共享资源 (BISR)：摘要 生物统计和信息学共享资源（BISR）在以下领域的研究活动中发挥着重要作用： 堪萨斯大学癌症中心 (KUCC) 通过支持 KUCC 研究人员的数据科学需求。 BISR 由 Byron Gajewski (CPC) 博士和 Devin Koestler (CB) 博士共同领导，两人均取得了成就 BISR 包括 19 名长期致力于跨学科合作的生物统计学家。 具有专门癌症生物统计学研究专业知识的教职人员、13 名技术支持人员和 博士后研究员和三名行政人员提供额外的技术和 BISR 通过提供行政专业知识来协助 KUCC 调查人员。 研究设计、统计监督和分析、临床研究信息学和 数据管理、电子数据收集、生物信息学、复杂数据集（统计“组学”）分析，以及 研究者发起的临床试验。 BISR 由教职员工组成，他们的专业知识和技能涵盖生物统计学、 这三个领域之间的大量重叠使研究人员能够 使用单一共享资源来满足他们的数据收集、分析和统计分析需求。 “数据科学”领域之间的协同作用使 BISR 能够支持广泛的质量 为支持 KUCC 成员的研究活动，提供及时且具有成本效益的服务。 该资源的具体目标是：1) 提供研究设计和统计支持及专业知识；2) 提供 生物信息学和统计遗传学支持和专业知识；3）为数据收集提供信息学专业知识； 和管理，以及开发和支持正在进行的研究支持技术、平台和 工具；4) 对 KUCC 的学生、研究员和教职人员进行数据科学、可重复研究方面的教育 2016 年至 2020 年，BISR 支持了 69、60、85、80 和 78 个癌症研究中使用的想法和方法。 2020 年，KUCC 成员分别为 18 名、33 名和 27 名来自癌症生物学、 癌症预防和控制，以及药物发现、递送和实验治疗，分别 89 项赠款申请（提交和重新提交）和 161 个项目（持续赠款、个人所得税和其他 此外，BISR 在 2020 年支持了 31 名非成员癌症研究人员。针对所有与癌症相关的研究人员。 BISR 在 2020 年支持了 340 个赠款申请和项目。2021 年，CCSG 资金占 约占 BISR 预算的 10%，年度直接支持投资回报约为 60 万美元 用于支持 BISR 教职员工的外部资金（BISR 支持的 31%）。