Mental health phenotypes shaped by trauma exposure, symptom severity, and individual characteristics among recent Latinx immigrant adults

近期拉丁裔移民成年人的心理健康表型受创伤暴露、症状严重程度和个人特征影响

• 批准号: 10660940
• 负责人: Laura X Vargas
• 金额: $ 12.08万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10660940
• 关键词: Adult; Age; Anxiety; Attention; Characteristics; Cohort Studies; Collaborations; Country; Crime; Cultural Backgrounds; Data; Development; Development Plans; Discrimination; Education; Equation; Ethics; Ethnic Origin; Evolution; Exposure to; Family; Foundations; Future; Gender; Goals; Grant; Growth; Health; Homicide; Human; Immigrant; Individual; Intervention; Intervention Studies; Interview; Latin America; Latinx; Lead; Longitudinal Studies; Marital Status; Measures; Mediating; Mental Depression; Mental Health; Mental Health Services; Mentored Research Scientist Development Award; Mentors; Methods; Mexico; Migrant; Modeling; National Institute on Minority Health and Health Disparities; Natural History; Outcome; Participant; Persons; Phenotype; Policies; Population; Population Policies; Positioning Attribute; Post-Traumatic Stress Disorders; Poverty; Prospective Studies; Public Health; Qualitative Methods; Research; Research Design; Research Methodology; Research Personnel; Sampling; Severities; Shapes; Site; Solid; Subgroup; Surveys; Symptoms; Testing; Time; Training; Translational Research; Trauma; Travel; Variant; Violence; Vulnerable Populations; base; bilingualism; career; career development; demographics; deprivation; design; experience; gender difference; health disparity; health service use; high risk; improved; innovation; intervention delivery; mental development; migration; perceived discrimination; programs; prospective; recruit; sex; therapy development; tool; trauma exposure; traumatic event; violence exposure; Adult; Age; Anxiety; Attention; Characteristics; Cohort Studies; Collaborations; Country; Crime; Cultural Backgrounds; Data; Development; Development Plans; Discrimination; Education; Equation; Ethics; Ethnic Origin; Evolution; Exposure to; Family; Foundations; Future; Gender; Goals; Grant; Growth; Health; Homicide; Human; Immigrant; Individual; Intervention; Intervention Studies; Interview; Latin America; Latinx; Lead; Longitudinal Studies; Marital Status; Measures; Mediating; Mental Depression; Mental Health; Mental Health Services; Mentored Research Scientist Development Award; Mentors; Methods; Mexico; Migrant; Modeling; National Institute on Minority Health and Health Disparities; Natural History; Outcome; Participant; Persons; Phenotype; Policies; Population; Population Policies; Positioning Attribute; Post-Traumatic Stress Disorders; Poverty; Prospective Studies; Public Health; Qualitative Methods; Research; Research Design; Research Methodology; Research Personnel; Sampling; Severities; Shapes; Site; Solid; Subgroup; Surveys; Symptoms; Testing; Time; Training; Translational Research; Trauma; Travel; Variant; Violence; Vulnerable Populations; base; bilingualism; career; career development; demographics; deprivation; design; experience; gender difference; health disparity; health service use; high risk; improved; innovation; intervention delivery; mental development; migration; perceived discrimination; programs; prospective; recruit; sex; therapy development; tool; trauma exposure; traumatic event; violence exposure

PROJECT SUMMARY/ABSTRACT Exposure to violence and trauma in Latin America significantly contributes to migration to the U.S., bringing attention to the mental health consequences of forced migration at the U.S./Mexico border. Traumatic events occur at every stage of migration and negatively impact mental health. Evidence suggests that Latinx immigrants in the U.S. enjoy an initial health advantage that erodes over time spent in the country as immigrants experience discrimination and are less likely to seek health and mental health care. Also, this health advantage comes into question when analyzed by sub-groups. Insufficient evidence exists of the intersection of trauma exposure; individual characteristics; and mental health outcomes of depression, anxiety, and PTSD among recent Latinx immigrant adults. This K01 Award proposes a mixed methods design that incorporates latent class analysis methods to develop mental health phenotypes of recent Latinx immigrants based on the intersections of trauma, individual characteristics and mental health. This research will develop ethical approaches to studying trauma and mental health cross-sectionally and set the foundation for future prospective research of mental health phenotype evolution to inform intervention development and delivery. This research has three specific aims: (1) Develop initial mental health phenotypes in a sample of recent Latinx immigrant adults using latent class analysis methods and examine their demographic and trauma exposure correlates (trauma exposure, sex, age, gender, marital status, education, country of origin and ethnicity); (2) Provide an in-depth understanding of participant experiences of trauma exposure and mental health to illuminate findings in SA1 using qualitative methods; and (3) Validate the phenotypes and any additional constructs that emerge from qualitative data with a second survey sample of 313 recent Latinx immigrant adults at the U.S./Mexico border. My career development plan includes three Training Goals: (1) Develop comprehensive expertise in structural equation modeling and latent class analysis methods as well as growth curve modeling and latent transition analysis; (2) Gain extensive expertise in qualitative and mixed methods research at the intersection trauma exposure, individual characteristics, and mental health of Latinx immigrants with an emphasis on space and time.; (3) Develop expertise in ethical conduct of human research with a public health impact, that includes understanding gender differences in trauma exposure, as well as recruitment and prospective retention of vulnerable populations; and (4) Develop broad expertise in dissemination and translation of research with immigrant populations for policy and practitioner audiences. This K01 Award will support my long-term career goal of becoming an independent investigator conducting ethical longitudinal and intervention research on the mental health of recent Latinx immigrants in the U.S. The research plan will produce data for a multi-site R01 prospective study on the trajectories of trauma exposure and mental health of Latinx immigrants to the U.S.

项目摘要/摘要 拉丁美洲的暴力和创伤的暴露显着促进了向美国移民 引起人们对在美国/Mexico边境强迫移民的心理健康后果的关注。创伤性 事件发生在迁移的每个阶段，并对心理健康产生负面影响。有证据表明拉丁裔 美国的移民享有最初的健康优势 移民经历歧视，不太可能寻求健康和精神卫生保健。另外，这个 当通过子组分析时，健康优势受到质疑。没有足够的证据 创伤暴露的交集；个人特征；以及抑郁症，焦虑，焦虑的心理健康结果 最近的拉丁裔移民成年人中的PTSD和PTSD。该K01奖提出了一种混合方法设计 结合了潜在的班级分析方法来开发最近拉丁移民的心理健康表型 基于创伤，个体特征和心理健康的交集。这项研究将发展 在研究创伤和心理健康横截面研究并为未来奠定基础的道德方法 对心理健康表型演变的前瞻性研究，以告知干预开发和交付。 这项研究具有三个特定的目的：（1）在样本中开发最初的心理健康表型 最近使用潜在班级分析方法的拉丁裔移民成年人检查他们的人口统计和创伤 暴露相关（创伤，性，性别，年龄，性别，婚姻状况，教育，原籍国和 种族）; （2）对参与者的创伤和心理经历提供深入的理解 使用定性方法在SA1中阐明发现的健康； （3）验证表型和任何 从定性数据中出现的其他结构，第二次调查样本为313个最近的拉丁裔 美国/Mexico边境的移民成年人。 我的职业发展计划包括三个培训目标：（1）建立全面的专业知识 结构方程建模和潜在类分析方法以及生长曲线建模和潜在 过渡分析； （2）在交叉路口获得定性和混合方法研究方面的广泛专业知识 拉丁裔移民的创伤暴露，个人特征和心理健康，重点是空间 和时间。 （3）发展具有公共卫生影响的人类研究道德行为的专业知识，其中包括 了解创伤暴露的性别差异，以及招募和前瞻性保留 弱势群体； （4）通过 政策和从业者受众的移民人口。这个K01奖将支持我的长期职业 成为一名独立调查员，进行道德纵向和干预研究 美国最近拉丁裔移民的心理健康研究计划将为多站点R01提供数据 关于拉丁人移民的创伤暴露和心理健康轨迹的前瞻性研究