Hot Flashes and Neurovascular Function in Women

女性潮热与神经血管功能

• 批准号: 10714724
• 负责人: Sarah Elizabeth Baker
• 金额: $ 5.4万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10714724
• 关键词: Adrenergic Agents; Aging; Area; Arteries; Baroreflex; Blood; Blood Vessels; Blood flow; Brain; Carbon Dioxide; Cardiovascular Diseases; Cerebrum; Clinical Trials; Complement; Cutaneous; Development; Endothelium; Evaluation; Feeling; Frequencies; Functional disorder; Goals; Hot flushes; Hypertension; Impaired cognition; Impairment; Incidence; Intervention; Knowledge; Learning; Life; Link; Lipids; Measures; Mediating; Menopause; Mentorship; Monitor; Mood Disorders; Muscle; Nerve; Obesity; Peripheral; Phenotype; Physiological; Physiology; Play; Prevention; Property; Regulation; Research; Resistance; Resolution; Rest; Risk; Risk Factors; Role; Running; Skeletal Muscle; Skin; Sleep; Sleep Disorders; Smooth Muscle; Stimulus; Sweating; System; Technical Expertise; Techniques; Tissues; Training; Vascular Endothelium; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents; White Matter Hyperintensity; Woman; Women' s Health; Work; cardiovascular disorder risk; career; career development; cerebrovascular; clinically relevant; design; diaries; effective intervention; experience; experimental study; heart rate variability; innovation; insight; middle age; neurotransmitter release; neurovascular; novel; prevent; response; stressor; vasomotor symptoms

PROJECT SUMMARY/ABSTRACT Vasomotor symptoms (hot flashes) associated with menopause consist of rapid and intense sweating, peripheral vasodilation, and an exaggerated feeling of internal heat. Over 70% of women experience hot flashes at some point during menopause, which significantly impacts day to day life. Furthermore, hot flash frequency is related to increased risk of hypertension, cardiovascular disease (CVD), sleep, and mood disorders--even when controlling for traditional cardiovascular disease risk factors (obesity, hypertension, lipids, etc.). As such, the overall goal of this application is to determine autonomic neurovascular function in midlife women with and without vasomotor symptoms (hot flashes). For the purposes of this application we will define neurovascular function as a concept that encompasses sympathetic outflow, the responses of blood vessels to neurotransmitters released by the sympathetic nerves and the intrinsic properties of the vascular endothelium and smooth muscle. It is thus related to the regulation of tissue blood flow. In this context, neurovascular function is critically important to women’s health and aging. Aim 1 will compare microvascular function in women with objectively assessed low and high frequency hot flashes. Aim 2 will determine autonomic function and reactivity in women with objectively assessed low and high frequency hot flashes. Finally, Aim 3 will characterize cerebrovascular function in women with objectively assessed low and high frequency hot flashes. Importantly, this work will provide the first comprehensive and mechanistic evaluation of autonomic and neurovascular function in midlife women including those undergoing menopause. Understanding how the neurovascular physiology of women relates to hot flashes will inform hypertension and cardiovascular disease (CVD) treatment and prevention options, as the presence of hot flashes are a CVD risk factor beyond traditional CVD risk factors and as such, is likely to be an important determinant for a woman’s health. Thus, the Applicant’s long-term goal is to develop interventions to reduce the incidence of cardiovascular disease in women with hot flashes. The proposed studies will build on the Applicant’s previous training and the mentorship team, formal course work on running clinical trials, and technical training plan will provide opportunities to gain additional knowledge in a new area and learn new experimental techniques and approaches. Finally, this work will generate an investigative niche that will complement the Applicant’s intellectual and technical skills that will facilitate the launch of her independent career.

项目概要/摘要 与更年期快速剧烈出汗相关的血管舒缩症状（潮热）， 周围血管舒张，以及过度的内热感 超过 70% 的女性会感到热。 在更年期的某个时刻会出现潮热，这会严重影响日常生活。 频率与高血压、心血管疾病 (CVD)、睡眠和情绪的风险增加有关 疾病——即使控制了传统的心血管疾病危险因素（肥胖、高血压、 因此，该应用的总体目标是确定自主神经血管功能。 有或没有血管舒缩症状（潮热）的中年女性。 将神经血管功能定义为代表交感神经流出、血液反应的概念 血管与交感神经释放的神经递质以及血管的内在特性 因此，它与组织血流的调节有关。 神经血管功能对女性健康和衰老至关重要，目标 1 将比较微血管。 目标 2 将确定客观评估低频率和高频率潮热的女性的功能。 客观评估低频率和高频率潮热的女性的自主功能和反应性。 最后，目标 3 将描述客观评估低和高的女性脑血管功能的特征 重要的是，这项工作将提供第一个全面和机械的评估。 中年女性（包括更年期女性）的自主神经和神经血管功能。 了解女性的神经血管生理学与潮热之间的关系将有助于高血压和 心血管疾病 (CVD) 的治疗和预防选择，因为潮热存在 CVD 风险 传统 CVD 危险因素之外的因素，因此可能是女性罹患心血管疾病的重要决定因素 因此，申请人的长期目标是干预发展以减少发病率。 拟议的研究将建立在申请人之前的研究基础上。 培训和指导团队、运行临床试验的正式课程以及技术培训计划将 提供获得新领域额外知识和学习新实验技术的机会 最后，这项工作将产生一个研究利基，以补充申请人的研究。 智力和技术技能将有助于她独立职业生涯的开展。