Center for Population Health and Aging

人口健康与老龄化中心

• 批准号: 10661129
• 负责人: SCOTT M. LYNCH
• 金额: $ 37.02万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-15 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10661129
• 关键词: Address; Administrative Supplement; Alzheimer' s disease related dementia; Birth; Centers for Population Health; Chemical Exposure; Chemicals; Data; Dentistry; Economics; Etiology; Exposure to; Home; Investigation; Life Cycle Stages; Link; Measures; Medicine; Methods; Neighborhoods; Outcome; Phase; Psychology; Research Infrastructure; Risk; Role; Science; Sensory; Sociology; aging brain; aging population; cohort; multidisciplinary; psychologic; social; social disparities; toxic metal

Abstract/Summary: We propose an administrative supplement to enhance the existing longitudinal Dunedin Study with, per NOSI-AG-22-022, “new exposure measures and mechanisms linking exposures to AD/ADRD outcomes.” The NOSI calls for new research infrastructure that “addresses the role of diverse physical, chemical, social, psychological, and economic exposures across multiple levels and across the life course in the etiology and social disparities” of AD/ADRD. The Dunedin Study, now in its 5th decade, has led the field in tracking social, psychological, and economic exposures since our cohort’s birth in 1972, using multidisciplinary methods spanning sociology, psychology, medicine, dentistry, sensory science, and economics. Here we propose to collect chemical and physical exposure data at Dunedin Phase 52. Doing so will make the Study one of the world’s first truly “exposomic” investigations of life-course brain aging and AD/ADRD risk. We propose to measure toxic metals, home environmental quality, and neighborhood environmental quality.

摘要/摘要：我们提出了一种行政补充，以增强现有的纵向 根据NOSI-AG-22-022，Dunedin研究，“新的暴露和机制联系了暴露 Toad/Adrd的结果。 跨倍数的各种物理，化学，社会，心理和经济暴露 跨越病因和社会差异的整个生活课程”。 第五个十年，领导了追踪社会，心理和经济暴露的领域 1972年的出生，使用跨学科方法，涵盖社会学，心理学，医学，牙科， 感觉科学和经济学。 达尼丁第52阶段。这样做将使研究成为该研究的“外汇”调查之一 生活方式的大脑衰老和广告/ADRD风险。 质量和邻里环境质量。