Characterization of socioeconomic and land use factors related to Aedes aegypti distribution in Maricopa County, Arizona

亚利桑那州马里科帕县与埃及伊蚊分布相关的社会经济和土地利用因素特征

• 批准号: 10664344
• 负责人: Whitney M Holeva-Eklund
• 金额: $ 0.26万
• 依托单位: NORTHERN ARIZONA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10664344
• 关键词: Aedes; Area; Arizona; Blood; Border Crossings; Censuses; Central America; Characteristics; Chikungunya virus; Cost of Illness; County; Coupled; Culicidae; Data; Dengue; Desert Climate; Disease; Disease Outbreaks; Ecology; Environmental Health; Genomics; Geography; Goals; Habitats; Health Sciences; Human; Infrastructure; Intervention; Laboratories; Latin America; Mexican; Mexico; Microcephaly; Mosquito Control; Mosquito-borne infectious disease; Movement; Neighborhoods; Persons; Population; Public Health; Public Health Informatics; Recommendation; Research; Research Personnel; Risk; Seasons; Socioeconomic Factors; Socioeconomic Status; Statistical Data Interpretation; Statistical Models; Temperature; Time; Travel; Vector-transmitted infectious disease; Yellow Fever; ZIKV infection; Zika Virus; base; burden of illness; career; climate change; cost; disease transmission; genome sequencing; health equity; land use; man; migration; mitochondrial genome; prevent; skills; socioeconomics; trait; transmission process; vector; vector control; vector mosquito

Project Summary Aedes aegypti mosquitoes are primary vectors of dengue, yellow fever, and the newly emerged threats of Zika and chikungunya viruses. In recent years, mosquito-borne diseases have reemerged as a pressing public health issue around the world, as the geographic range of mosquitoes has increased rapidly due to expanded global trade and travel and potentially due to increased temperatures caused by climate change. Maricopa County, Arizona is potentially at risk for developing Ae. aegypti transmitted diseases due to the established presence of the mosquito vector and the high volume of travelers coming to Arizona from areas with endemic Ae. aegypti- borne disease. In fact, on average, over 25 million travelers cross the border from Mexico (an area with diseases transmitted by the vector) into Arizona each year. Although much research exists on the wide-scale distribution of mosquito vectors, there is less understanding of the local factors that promote mosquito populations or the geographic range of the mosquitoes, especially in a desert climate. It is not known whether there are local socioeconomic or environmental characteristics that support larger Ae. aegypti populations or how mosquitoes move between local populations. We will use a combination of statistical analysis, spatial analysis, and phylogenomic analysis to develop a better understanding of the local factors that support mosquito populations and how mosquito populations are moving over time and space. The long-term goal of this project is to identify small-scale socioeconomic or landscape characteristics that consistently support Ae. aegypti populations and implement interventions with the Vector Control Division in Maricopa County, AZ to reduce mosquito populations, thereby reducing disease transmission risk. The rationale for this application is that the understanding of the distribution, range, and movement of the mosquito populations is a critical component of implementing effective public health efforts that can reduce disease burden and cost by aiming to prevent potential outbreaks of mosquito-borne disease. Hypothesis: Ae. aegypti will not be uniformly distributed throughout Maricopa County, with some areas having larger populations due to differences in infrastructure or landscape characteristics (which are related to neighborhood socioeconomic status) and therefore potential mosquito habitat. Furthermore, we hypothesize that genetically distinct populations will be separated by short distances and will be unique to specific neighborhoods. Aim 1: Characterize the neighborhood socioeconomic factors associated with Ae. aegypti abundance. Aim 2: Characterize landscape traits, such as greenness, that are associated with Ae. aegypti populations. Aim 3: Characterize the origin of and migration between local Ae. aegypti mosquito populations within Maricopa County, Arizona.

项目概要 埃及伊蚊是登革热、黄热病和新出现的寨卡病毒威胁的主要传播媒介 和基孔肯雅病毒。近年来，蚊媒疾病重新成为紧迫的公共卫生问题 由于全球范围的扩大，蚊子的地理范围迅速扩大，这是世界各地的一个问题 贸易和旅行，也可能是由于气候变化引起的气温升高。马里科帕县 亚利桑那州有可能面临感染白斑伊蚊的风险。由于埃及伊蚊的存在而传播疾病 蚊媒以及从白伊蚊流行地区来到亚利桑那州的大量旅客。埃及伊蚊- 传染的疾病。事实上，平均有超过 2500 万旅客从墨西哥（疾病流行地区）跨越边境。 每年通过媒介传播）进入亚利桑那州。尽管有很多关于大规模分布的研究 对于蚊子媒介，人们对促进蚊子数量的当地因素或蚊子数量的了解较少。 蚊子的地理范围，特别是在沙漠气候下。不知道当地是否有 支持较大 Ae 的社会经济或环境特征。埃及伊蚊种群或蚊子如何 在当地人口之间流动。我们将结合统计分析、空间分析和 系统基因组分析，以更好地了解支持蚊子种群的当地因素 以及蚊子种群如何随时间和空间移动。该项目的长期目标是确定 始终支持 Ae 的小规模社会经济或景观特征。埃及伊蚊种群和 与亚利桑那州马里科帕县病媒控制部门一起实施干预措施，以减少蚊子数量 人群，从而降低疾病传播风险。此应用程序的基本原理是 了解蚊子种群的分布、范围和移动是蚊子种群的重要组成部分 实施有效的公共卫生工作，通过预防疾病来减轻疾病负担和成本 蚊媒疾病的潜在爆发。 假设：Ae。埃及伊蚊不会均匀分布在整个马里科帕县，部分地区 由于基础设施或景观特征的差异（与 社区的社会经济地位）以及潜在的蚊子栖息地。此外，我们假设 遗传上不同的种群将相距很短的距离，并且对于特定的种群来说是独一无二的 社区。 目标 1：描述与 Ae 相关的社区社会经济因素。埃及伊蚊数量丰富。 目标 2：描述与 Ae 相关的景观特征，例如绿色度。埃及伊蚊种群。 目标 3：描述当地白伊蚊的起源和迁移。境内埃及蚊种群数量 亚利桑那州马里科帕县。