Characterization of socioeconomic and land use factors related to Aedes aegypti distribution in Maricopa County, Arizona

亚利桑那州马里科帕县与埃及伊蚊分布相关的社会经济和土地利用因素特征

• 批准号: 10664344
• 负责人: Whitney M Holeva-Eklund
• 金额: $ 0.26万
• 依托单位: NORTHERN ARIZONA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10664344
• 关键词: Aedes; Area; Arizona; Blood; Border Crossings; Censuses; Central America; Characteristics; Chikungunya virus; Cost of Illness; County; Coupled; Culicidae; Data; Dengue; Desert Climate; Disease; Disease Outbreaks; Ecology; Environmental Health; Genomics; Geography; Goals; Habitats; Health Sciences; Human; Infrastructure; Intervention; Laboratories; Latin America; Mexican; Mexico; Microcephaly; Mosquito Control; Mosquito-borne infectious disease; Movement; Neighborhoods; Persons; Population; Public Health; Public Health Informatics; Recommendation; Research; Research Personnel; Risk; Seasons; Socioeconomic Factors; Socioeconomic Status; Statistical Data Interpretation; Statistical Models; Temperature; Time; Travel; Vector-transmitted infectious disease; Yellow Fever; ZIKV infection; Zika Virus; base; burden of illness; career; climate change; cost; disease transmission; genome sequencing; health equity; land use; man; migration; mitochondrial genome; prevent; skills; socioeconomics; trait; transmission process; vector; vector control; vector mosquito

Project Summary Aedes aegypti mosquitoes are primary vectors of dengue, yellow fever, and the newly emerged threats of Zika and chikungunya viruses. In recent years, mosquito-borne diseases have reemerged as a pressing public health issue around the world, as the geographic range of mosquitoes has increased rapidly due to expanded global trade and travel and potentially due to increased temperatures caused by climate change. Maricopa County, Arizona is potentially at risk for developing Ae. aegypti transmitted diseases due to the established presence of the mosquito vector and the high volume of travelers coming to Arizona from areas with endemic Ae. aegypti- borne disease. In fact, on average, over 25 million travelers cross the border from Mexico (an area with diseases transmitted by the vector) into Arizona each year. Although much research exists on the wide-scale distribution of mosquito vectors, there is less understanding of the local factors that promote mosquito populations or the geographic range of the mosquitoes, especially in a desert climate. It is not known whether there are local socioeconomic or environmental characteristics that support larger Ae. aegypti populations or how mosquitoes move between local populations. We will use a combination of statistical analysis, spatial analysis, and phylogenomic analysis to develop a better understanding of the local factors that support mosquito populations and how mosquito populations are moving over time and space. The long-term goal of this project is to identify small-scale socioeconomic or landscape characteristics that consistently support Ae. aegypti populations and implement interventions with the Vector Control Division in Maricopa County, AZ to reduce mosquito populations, thereby reducing disease transmission risk. The rationale for this application is that the understanding of the distribution, range, and movement of the mosquito populations is a critical component of implementing effective public health efforts that can reduce disease burden and cost by aiming to prevent potential outbreaks of mosquito-borne disease. Hypothesis: Ae. aegypti will not be uniformly distributed throughout Maricopa County, with some areas having larger populations due to differences in infrastructure or landscape characteristics (which are related to neighborhood socioeconomic status) and therefore potential mosquito habitat. Furthermore, we hypothesize that genetically distinct populations will be separated by short distances and will be unique to specific neighborhoods. Aim 1: Characterize the neighborhood socioeconomic factors associated with Ae. aegypti abundance. Aim 2: Characterize landscape traits, such as greenness, that are associated with Ae. aegypti populations. Aim 3: Characterize the origin of and migration between local Ae. aegypti mosquito populations within Maricopa County, Arizona.

项目摘要 埃及埃及蚊子是登革热的主要载体，黄热病和新出现的Zika威胁 和chikungunya病毒。近年来，蚊子传播的疾病已重新出现为紧迫的公共卫生 世界各地的问题，由于蚊子的地理范围由于全球扩大而迅速增加 贸易和旅行，可能是由于气候变化引起的温度升高。马里科帕县， 亚利桑那州可能有发展AE的风险。由于既定存在，埃及传播疾病 蚊子向量和大量的旅行者从具有AE的地区来到亚利桑那州。埃及 疾病。实际上，平均有超过2500万旅客从墨西哥越过边界（这是有疾病的地区 每年由矢量传输到亚利桑那州。尽管对广泛分布的研究存在很多研究 蚊子向量，对促进蚊子种群或 蚊子的地理范围，尤其是在沙漠气候下。不知道是否有本地 支持更大AE的社会经济或环境特征。埃及人口或蚊子如何 在当地人群之间移动。我们将结合统计分析，空间分析和 系统基因分析以更好地了解支持蚊子种群的局部因素 以及蚊子种群如何随时间和空间移动。该项目的长期目标是确定 始终支持AE的小型社会经济或景观特征。埃及人口和 与亚利桑那州马里科帕县的矢量控制部门实施干预措施，以减少蚊子 种群，从而降低了疾病传播风险。此应用程序的理由是 了解蚊子种群的分布，范围和运动是 实施有效的公共卫生努力，以减轻疾病负担和成本，以防止 蚊子传播疾病的潜在暴发。 假设：AE。埃及在马里科帕县不会均匀分布，某些地区 由于基础设施或景观特征的差异，人口较大（与 社区社会经济地位），因此潜在的蚊子栖息地。此外，我们假设 遗传上不同的种群将被短距离分开，并且特定于特定 社区。 目标1：特征与AE相关的社区社会经济因素。埃及丰度。 目标2：特征与AE相关的景观特征，例如绿色。埃及人口。 AIM 3：表征本地AE之间的起源和迁移。埃及蚊子种群 亚利桑那州马里科帕县。