Neural and behavioral trajectories of the overcontrolled phenotype: Associations with development, social context and psychiatric symptoms in early childhood

过度控制表型的神经和行为轨迹：与幼儿期发育、社会背景和精神症状的关联

• 批准号: 10654803
• 负责人: Kirsten Gilbert
• 金额: $ 73.89万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10654803
• 关键词: 6 year old; 9 year old; Adolescence; Adult; Age; Anorexia Nervosa; Attenuated; Behavioral; Behavioral Mechanisms; Child; Child Rearing; Childhood; Chronic; Cognitive; Communities; Crystallization; Data; Development; Diagnostic; Dimensions; Disease; Early Intervention; Early identification; Electroencephalography; Evaluation; Event-Related Potentials; Exhibits; Frequencies; Functional disorder; Goals; Grain; Impairment; Intervention; Investigation; Knowledge; Longevity; Mental disorders; Mentored Patient-Oriented Research Career Development Award; Methods; Monitor; Neurobiology; Neuronal Plasticity; Obsessive-Compulsive Disorder; Onset of illness; Outcome; Performance; Phenotype; Process; Psychopathology; Public Health; Research; Research Domain Criteria; Resistance; Risk; Sampling; School-Age Population; Schools; Severities; Social Anxiety Disorder; Social Development; Social Environment; Social Processes; Symptoms; Techniques; Time; aged; cognitive control; cognitive development; cognitive process; comorbidity; contextual factors; control theory; cost effective; design; early childhood; experience; high risk; improved; indexing; insight; neural; neurobiological mechanism; neurodevelopment; novel; parental influence; peer; peer influence; psychiatric symptom; recruit; response; severe psychiatric disorder; social; social influence

PROJECT SUMMARY Heightened performance monitoring and overcontrol (HPM/OC) is a transdiagnostic phenotype comprised of perfectionism, extreme concern for errors, cognitive inflexibility and excessive need for control. There is increasing evidence that the HPM/OC phenotype is identifiable in early childhood and underlies obsessive- compulsive disorder (OCD), social anxiety disorder (SAD) and anorexia nervosa (AN). These psychiatric disorders are severe, chronic, and treatment-resistant disorders with high rates of comorbidity. However, there is surprisingly little research examining the neurobiological and behavioral mechanisms that make up the HPM/OC phenotype in early school-age childhood in relation to the development of transdiagnostic psychiatric symptoms. Moreover, it is unknown how the HPM/OC phenotype interacts with rapid developmental progression during this age or is influenced by social-contextual features, such as social evaluation, peer rejection or parenting styles. Determining answers to these fundamental questions could provide insight into the emergence of the HPM/OC phenotype and provide novel treatment targets for early intervention. The goal of the current proposal is to improve understanding of the HPM/OC phenotype in early childhood in relation to early markers of OCD and SAD by assessing the developmental progression of cognitive facets of performance monitoring and reactive versus proactive cognitive control and the influence of social-contextual features on psychiatric outcomes. We posit that cognitive processes that make up the HPM/OC phenotype, including heightened performance monitoring and more reactive versus proactive cognitive control, interact with various social contexts to differentiate early school-age children with impairing HPM/OC. The early school- age period is when HPM/OC is first evident and is a time of rapid cognitive and social development, making it a pivotal time to understand the developmental psychopathology of this presentation. We will employ cutting- edge and cost-effective electroencephalogram (EEG) event-related potential (ERP) and time-frequency (TF) analyses to examine multiple Research Domain Criteria (RDoC) constructs across three repeated yearly assessments in a sample of 300 community children oversampled for elevated dimensional HPM/OC, ages spanning 4 - 9 years. This fine-grained evaluation will provide an opportunity to characterize 1) how HPM/OC impacts normative neurodevelopmental trajectories of RDoC constructs during an age of high neural plasticity, 2) the developmental progression of cognitive facets of the HPM/OC phenotype in relation to transdiagnostic psychiatric impairment and 3) the impact of social-contextual features that may influence these relationships. This knowledge could have far-reaching effects on our understanding of the early neurodevelopment of the HPM/OC phenotype prior to disorder onset, which could inform early identification of high-risk children and targeted early interventions that could lessen the severity, course and impairment of multiple psychiatric disorders across the lifespan.

项目概要 增强的表现监测和过度控制（HPM/OC）是一种跨诊断表型，包括 完美主义、极度关注错误、认知僵化和过度需要控制。有 越来越多的证据表明，HPM/OC 表型在幼儿期是可以识别的，并且是强迫症的基础。 强迫症（OCD）、社交焦虑症（SAD）和神经性厌食症（AN）。这些精神病 疾病是严重的、慢性的、难治性的疾病，并存疾病的发生率很高。然而，有 令人惊讶的是，很少有研究检查构成神经生物学和行为机制的研究。 学龄儿童早期 HPM/OC 表型与跨诊断精神病学发展的关系 症状。此外，目前尚不清楚 HPM/OC 表型如何与快速发育相互作用。 在此年龄段的进步或受到社会背景特征的影响，例如社会评价、同伴 拒绝或养育方式。确定这些基本问题的答案可以深入了解 HPM/OC 表型的出现并为早期干预提供新的治疗靶点。目标 当前提案的目的是提高对幼儿期 HPM/OC 表型的理解 通过评估 OCD 和 SAD 认知方面的发展进程来确定 OCD 和 SAD 的早期标志 表现监控和反应性与主动性认知控制以及社会情境的影响 精神结果的特征。我们假设构成 HPM/OC 表型的认知过程， 包括加强绩效监控以及更具反应性与主动性的认知控制、互动 结合不同的社会背景来区分具有 HPM/OC 受损的学龄早期儿童。早期的学校—— 年龄阶段是 HPM/OC 首次明显出现的时期，也是认知和社会性快速发展的时期，使其成为 是理解本次演讲的发展精神病理学的关键时刻。我们将采用切割- 边缘且经济高效的脑电图 (EEG) 事件相关电位 (ERP) 和时频 (TF) 分析以检查每年三个重复的多个研究领域标准 (RDoC) 结构 对 300 名社区儿童样本进行过采样评估，以提高维度 HPM/OC、年龄 跨度4-9年。这种细粒度的评估将提供一个机会来描述 1) HPM/OC 如何 在神经可塑性高的时代影响 RDoC 结构的规范神经发育轨迹， 2）与跨诊断相关的HPM/OC表型认知方面的发展进程 精神障碍；3）可能影响这些关系的社会背景特征的影响。 这些知识可能会对我们对人类早期神经发育的理解产生深远的影响。 疾病发作前的 HPM/OC 表型，可以帮助早期识别高危儿童和 有针对性的早期干预措施可以减轻多种精神疾病的严重程度、病程和损害 整个生命周期的疾病。