Testing a Biopsychosocial Model of Violence Exposure, Minority Stressors, and Hazardous Drinking among Sexual Minority Women

测试性少数女性中暴力暴露、少数压力源和危险饮酒的生物心理社会模型

基本信息

批准号：
10403609
负责人：
Jillian R Scheer
金额：
$ 17.38万
依托单位：
SYRACUSE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-06-01 至 2026-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10403609
关键词：
Address Adult Alcohol consumption Alcohols Biological Cardiovascular system Chicago Childhood Clinical Discrimination Doctor of Philosophy Ecological momentary assessment Ensure Epidemiology Ethnic Origin Exposure to Face Galvanic Skin Response Goals Growth Health Heart Rate Heterogeneity Heterosexuals Homophobia Hydrocortisone Knowledge Laboratories Lead Life Experience Link Literature Longevity Measurement Mental Health Mentored Research Scientist Development Award Mentors Methods Modeling Morbidity - disease rate National Institute on Alcohol Abuse and Alcoholism Outcome Pattern Physiological Play Population Population Heterogeneity Populations at Risk Post-Traumatic Stress Disorders Prevention Principal Investigator Psychophysiology Public Health Race Recording of previous events Reporting Research Research Methodology Research Personnel Research Priority Risk Role Salivary Sampling Scientist Self Medication Sex Orientation Sexual abuse Stigmatization Stimulus Stress Subgroup Surveys Symptoms System Testing Time Training Trier Social Stress Test Universities Variant Violence Woman Work alcohol abuse therapy alcohol craving alcohol intervention alcohol relapse alcohol research alcohol risk alcohol use disorder allostatic load base biological adaptation to stress biopsychosocial comorbidity coping drinking effective therapy ethnic difference experience hazardous drinking heart rate variability innovation men minority stressor physical abuse polyvictimization psychosocial stressors racial and ethnic racial difference racial diversity reduced alcohol use sexual assault sexual minority sexual minority women sexual victimization skills stress reactivity stressor success tool treatment adherence treatment response violence against women violence exposure virtual women of color

项目摘要

Project Summary/Abstract Women disproportionately experience violence compared to men;21-23 however, violence against women is not distributed randomly. Due, in part, to their stigmatized identity, sexual minority women (SMW) are 2-3 times more likely to face violence than heterosexual women.21, 24-26 Many women use alcohol to cope with the negative sequelae of violence (e.g., PTSD).28 This comorbidity may be exacerbated among SMW given their experiences of psychosocial stressors (i.e., violence and minority stressors such as discrimination).11 Despite the public health necessity of developing targeted alcohol treatment approaches for victimized SMW, current alcohol treatment models do not specify unique stressors and clinical needs of this population. Consistent with the NIAAA’s research priorities,11, 14 the K01 will provide major advances in understanding biopsychosocial mechanisms (e.g., minority stressors, physiological reactivity, PTSD) and moderators (e.g., race/ethnicity) influencing the heterogeneity in hazardous drinking among SMW as well as the role that these core factors play in SMW’s differential need for and response to treatment. The project will include: 1) an epidemiologic assessment that uncovers distinct combinations of psychosocial stressors among SMW, identifies racial/ethnic differences in classes of psychosocial stressors, and determines how these patterns of psychosocial stressors predict comorbid PTSD and hazardous drinking over 11 years (n = 450-600); 2) a lab-based study that advances knowledge of the influence of minority stressors on allostatic load (e.g., salivary cortisol, heart rate, heart rate variability, and skin conductance) among victimized SMW (n = 125); and, 3) a once-daily ecological momentary assessment (EMA) approach over 21 days that determines the role of minority stressors as antecedents to daily fluctuations in PTSD and hazardous drinking using the same sample of SMW from the lab-based study. The proposed training plan in this K01 application will provide essential knowledge and skills that the principal investigator, Jillian R. Scheer, PhD, needs to become an independent, interdisciplinary alcohol scientist. The advanced training acquired by Dr. Scheer via this timely and innovative project will target 3 objectives: (1) rigorous alcohol research methodology and its application to studying determinants of hazardous drinking patterns; (2) physiological measurement of stress reactivity as a tool to assess biological mechanisms underlying the influence of minority stressors on comorbid PTSD and hazardous drinking; and, (3) EMA approaches to assess the proximal effects of minority stressors on daily comorbid PTSD and hazardous drinking among racially diverse SMW. Dr. Scheer will be primarily mentored by John Pachankis, PhD, at Yale University, with additional mentoring from Tonda Hughes, PhD (Columbia University), Rajita Sinha, PhD (Yale University), Tami Sullivan, PhD (Yale University), Joshua Warren, PhD (Yale University), and Robert Pietrzak, PhD, MPH (Yale University). Dr. Scheer’s training through the K01 award will ensure her success as an independent scientist whose work informs public health and clinical efforts to reduce alcohol use among SMW.

项目概要/摘要与男性相比，女性遭受暴力的比例过高；21-23 然而，针对女性的暴力行为并不存在部分由于其被污名化的身份，性少数女性 (SMW) 的比例是随机分布的 2-3 倍。比异性恋女性更有可能面临暴力。21, 24-26 许多女性使用酒精来应对暴力。暴力的负面后遗症（例如创伤后应激障碍）。 28 鉴于 SMW 的健康状况，这种合并症可能会加剧。心理社会压力源的经历（即暴力和歧视等少数族裔压力源）。11 尽管为受害的 SMW 制定有针对性的酒精治疗方法的公共卫生必要性，目前酒精治疗模型没有具体说明该人群的独特压力源和临床需求。 NIAAA 的研究重点，11, 14 K01 将在理解生物心理社会方面取得重大进展机制（例如，少数压力源、生理反应、创伤后应激障碍）和调节因素（例如，种族/民族）影响SMW危险饮酒异质性的因素以及这些核心因素的作用该项目将包括：1）流行病学研究。揭示 SMW 中社会心理压力因素的不同组合的评估，识别种族/民族社会心理压力源类别的差异，并决定这些社会心理压力源的模式预测 11 年内的共病 PTSD 和危险饮酒 (n = 450-600) 2) 一项基于实验室的研究，该研究取得了进展了解少数压力源对稳态负荷的影响（例如唾液皮质醇、心率、心率受害 SMW（n = 125）中的变异性和皮肤电导率）；以及，3）每日一次生态检查；持续 21 天的瞬时评估 (EMA) 方法确定少数压力源的作用：使用来自 SMW 的相同样本分析 PTSD 和危险饮酒每日波动的前因本 K01 应用程序中拟议的培训计划将提供必要的知识和技能。首席研究员 Jillian R. Scheer 博士需要成为一名独立的、跨学科的谢尔博士通过这个及时且创新的项目获得的高级培训将针对酒精科学家。 3 个目标：(1) 严格的酒精研究方法及其在研究酒精决定因素中的应用 (2) 应激反应的生理测量作为评估生物学的工具少数压力源对共病创伤后应激障碍和危险饮酒的影响机制；(3) EMA 方法评估少数压力源对日常共病 PTSD 和危险的近端影响 Scheer 博士将主要由耶鲁大学 John Pachankis 博士指导。大学，并得到 Tonda Hughes 博士（哥伦比亚大学）、 Rajita Sinha 博士（耶鲁大学）的额外指导大学）、Tami Sullivan 博士（耶鲁大学）、Joshua Warren 博士（耶鲁大学）和 Robert Pietrzak，博士、公共卫生硕士（耶鲁大学）谢尔博士通过 K01 奖项的培训将确保她作为一名成功的人。独立科学家，其工作为公共健康和减少 SMW 饮酒的临床工作提供信息。