The role of cognitive load on lateralized motor control processes

认知负荷对偏侧运动控制过程的作用

• 批准号: 10646023
• 负责人: Shanie Amanda Liyanagamage Jayasinghe
• 金额: $ 23.25万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10646023
• 关键词: Activities of Daily Living; Address; Affect; Behavior; Brain Injuries; Clinical assessments; Cognition; Cognitive; Cognitive deficits; Data; Dependence; Dissociation; Elbow; Electromyography; Foundations; Goals; Hand functions; Handedness; Impaired cognition; Impairment; Individual; Knowledge; Left; Literature; Measures; Methods; Motion; Motor; Movement; Muscle; Nature; Paresis; Performance; Physical Rehabilitation; Play; Preparation; Process; Reaction Time; Rehabilitation therapy; Research; Role; Short-Term Memory; Shoulder; Side; Standardization; Stroke; Surface; System; Testing; Training; Upper Extremity; Work; arm; arm function; arm movement; arm paresis; chronic stroke; clinically relevant; cognitive load; cognitive neuroscience; cognitive process; design; dexterity; disability; evidence base; experience; experimental study; functional independence; functional outcomes; hemiparesis; hemisphere damage; improved; indexing; kinematics; motor control; motor deficit; motor learning; novel; post stroke; recruit; rehabilitation strategy; remediation; stroke rehabilitation; stroke survivor; virtual reality

Project Summary/Abstract Upper limb physical rehabilitation post stroke tends to focus mainly on remediating deficits related to motor execution of the impaired arm. This approach can be problematic due to two major reasons: (1) efficient movement requires both intact cognition and motor execution, and (2) previous research shows that movement deficits depend on the side of brain damage; importantly, these deficits are present even in the “unimpaired”, ipsilesional arm. While there is a large body of evidence on the lateralization of motor control processes, research on lateralized cognitive processes is limited. Previous studies show that right brain damage produces larger deficits in cognitive processes, such as working memory and action selection, than left brain damage. Our preliminary studies examining hemisphere-specific deficits in motor execution demonstrate that ipsilesional arm movement planning deficits in individuals with left brain damage are highly correlated with functional independence. Surprisingly, this relationship was not found in individuals with right brain damage. Based on our preliminary studies and prior literature, we hypothesize that increased cognitive load produces functionally limiting deficits in the control of movement that differ based on the side of brain damage. We predict that with increased cognitive load, movement deficits will be larger with right than left brain damage. Additionally, we predict that functional independence will be correlated with cognitive deficits in right hemisphere damaged individuals and with motor execution deficits in left hemisphere damaged individuals. We will utilize a novel paradigm that integrates a cognitive challenge with an upper limb reaching task. This method provides a more real-world design for studying how cognitive load affects functional movement compared to dual-task paradigms that involve a cognitively-challenging task in parallel with the motor task. We will recruit 36 chronic stroke survivors with severe hemiparesis for our studies. They will each complete two tasks on a virtual reality motion tracking system, which are designed to assess deficits in ipsilesional arm motor execution and cognitive aspects of movement. We will also use standardized clinical assessments of ipsilesional arm function and functional independence. This proposal assembles an investigative team comprised of experts in cognitive neuroscience and stroke rehabilitation to accomplish the following aims: (1) To determine whether ipsilesional arm deficits in motor control are affected by cognitive load differently in left and right hemisphere damaged stroke survivors with severe contralesional paresis; (2) To determine whether deficits in ipsilesional arm motor execution and cognitive aspects of movement predict functional independence differently between left and right hemisphere damaged stroke survivors with severe contralesional paresis. The results of these studies will be used to develop personalized rehabilitation strategies that account for hemisphere-specific deficits in motor control, and will be particularly useful for severely impaired stroke survivors who depend exclusively on their ipsilesional arm to conduct activities of daily living.

项目摘要/摘要 上肢康复后，中风后倾向于tocus，主要是在修复缺陷的节奏上 由于两个主要原因 运动需要完整的认知和运动执行，（2）先前的研究表明运动 缺陷取决于脑损伤的一侧； ipsiles臂。 对横向认知过程的研究有限。 与左脑损伤相比，认知过程中的缺陷（例如工作记忆和动作选择）更大。 我们在运动执行仪中检查半球特异性的初步研究证明了这一点 手臂运动计划缺陷左脑损伤的人与功能高度相关 独立。 我们的初步研究和先前的文献，我们假设增加认知负荷会产生功能 根据大脑损伤的一侧，限制运动控制的缺陷。 与左脑损伤相比，认知负荷增加了 预测功能独立性与右半球的认知缺陷相关 左半球处执行缺陷的人，我们将利用一个新颖的人 将Challlenge与上肢达到的任务相结合的范式。 与双重任务相比，用于研究认知负荷如何影响功能运动的现实设计如何影响功能运动 涉及与运动任务同行的认知挑战任务的范例。 中风幸存者，我们的研究都有严重的偏瘫。 运动跟踪系统，旨在评估缺陷缺陷ipsiles臂运动执行和认知 运动的各个方面。 功能独立性。 神经科学和中风康复以实现以下目的：（1）确定是否iSilesionsions 运动控制中的手臂缺陷受认知负荷的影响，在左右半乳中损坏了 中风幸存者患有严重的缔结减轻； 左右之间的运动独立性的执行和认知方面的执行和认知方面 Hemisephere损坏的中风幸存者患有严重的违反学院。 用于制定个性化的康复策略，以解释运动中半球特异性 控制权，对于严重受损的中风幸存者，他们专门依赖于 ipsiles臂进行日常生活活动。