NIDDK Multidisciplinary Predoctoral Training in Discovery and Translational Research

NIDDK 发现和转化研究多学科博士前培训

• 批准号: 10392357
• 负责人: DANIEL D BILLADEAU
• 金额: $ 20.91万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10392357
• 关键词: National Institute of Diabetes and Digestive and Kidney Diseases; Training; Translational Research; multidisciplinary; pre-doctoral

PROJECT SUMMARY/ABSTRACT This is a new application for multidisciplinary predoctoral training in discovery and translational research at Mayo Clinic in the inter-related fields of Diabetes and Metabolic Disease, Digestive Diseases and Gastroenter- ology, and Kidney Disease and Hypertension (DDK). The overarching objective is to develop a diverse pool of well-trained biomedical career scientists with the experience and skillsets to become leaders in the next gener- ation of DDK researchers. Two senior and accomplished Mayo scientists with an extensive background in graduate education and mentoring will co-direct this program centered upon four Mechanism-Centric Research Communities in i) Bioengineering and Biophysical Analysis, ii) Cell-to-Cell Communication, iii) Genomic Regu- lation, and iv) Intracellular Signaling, with 24 interdisciplinary faculty members and over $20 million in funding. This core DDK faculty provides a robust infrastructure with a successful history of training career scientists in discovery-based and translational biomedical research. These laboratories offer a rich mentoring and training environment that is uniquely tailored to the individual student while also promoting collective experiences across multiple disciplines. The program's Specific Aims focus on fundamental aspects of reproducible and rigorous biomedical research that align with NIH/NIDDK priorities. These are to: i) Offer a solid foundation in scientific reasoning, research design, rigor, quantitative experimental approaches and analysis of datasets, with objective interpretation of results; ii) Foster broad multidisciplinary understanding combined with critical independent thinking skills, while implementing the ability to identify outstanding biomedical questions and ini- tiate new approaches to advance the field; iii) Develop effective oral and written communication skills across diverse audiences; iv) Promote ethical conduct in biomedical research and team skills that facilitate collabora- tive scientific research alongside colleagues while promoting an inclusive work environment; v) Provide the background to identify and effectively transition into productive basic and clinical DDK investigators. The pro- gram strongly supports synergistic interactions between Mayo Clinic Basic Science Departments and NIDDK- funded Centers in Digestive Disease, Translational PKD, and Pathobiology of the Enteric System. The stu- dents will actively engage in a full array of programmatic activities, including journal clubs, seminar and works- in-progress series, career and professional development events, annual retreat, Mayo Graduate School wide symposium and poster session, along with participation in national meetings and others. These activities syn- ergize with three related DDK postdoctoral programs at Mayo Clinic in Diabetes and Metabolism, Digestive Diseases, and Kidney Disease, while offering a complete continuum from summer undergraduate research experiences through PhD and postdoctoral training. Requirements for completion of the PhD degree conform to Mayo Graduate School requirements, including a first author publication. The program draws from a strong pool of 75+ qualified Mayo Clinic graduate students; we request support for six predoctoral trainees per year.

项目摘要/摘要 这是一个新的应用程序，用于在发现和转化研究中的多学科前培训 糖尿病和代谢疾病，消化系统疾病和胃肠疾病的相关领域的梅奥诊所 OLOGOL，肾脏疾病与高血压（DDK）。总体目标是开发多种多样的池 训练有素的生物医学职业科学家具有经验和技能，可以在下一家中成为领导者 DDK研究人员的研究。两位高级和有成就的梅奥科学家，具有广泛背景 研究生教育和指导将共同指导该计划以四个以机制为中心的研究 i）生物工程和生物物理分析的社区，ii）细胞到细胞通信，iii）基因组调节 lation和iv）细胞内信号传导，有24个跨学科的教职员工和超过2000万美元的资金。 这种核心DDK教师提供了一个强大的基础设施，并在培训职业科学家的历史上成功 基于发现和转化的生物医学研究。这些实验室提供丰富的指导和培训 为个人学生量身定制的环境，同时还促进集体体验 跨多个学科。该计划的具体目的侧重于可再现的基本方面 与NIH/NIDDK优先级保持一致的严格生物医学研究。这些是：i）在 科学推理，研究设计，严格，定量实验方法和数据集分析， 与结果的客观解释； ii）促进广泛的多学科理解与关键 独立的思维技能，同时实施确定杰出的生物医学问题的能力和 采用新的方法来推进该领域； iii）跨越有效的口头和书面沟通技巧 不同的受众； iv）促进生物医学研究和团队技能的道德行为，以促进合作 与同事一起进行科学研究，同时促进包容性的工作环境； v）提供 背景识别并有效地过渡到生产性基本和临床DDK研究者。专业人士 克强烈支持Mayo诊所基础科学部门与NIDDK-之间的协同互动 肠道系统的消化系统疾病，转化PKD和病理生物学的资助中心。 Stu- Dents将积极从事各种计划活动，包括期刊俱乐部，研讨会和工程 - 过程内系列，职业和专业发展活动，年度静修会，梅奥研究生院广泛 研讨会和海报会议，以及参加国家会议和其他会议。这些活动合成 在糖尿病和代谢的梅奥诊所的三个相关DDK博士后计划中 疾病和肾脏疾病，同时提供夏季本科研究的完整连续性 通过博士和博士后培训的经验。填写博士学位的要求 满足梅奥研究生院的要求，包括第一作者出版物。该程序从一个强大的 75多个合格的梅奥诊所研究生的池；我们要求支持每年六名五名学员。