Neural Mapping of the Social Landscape

社会景观的神经映射

基本信息

批准号：
10391316
负责人：
Matthew Schafer
金额：
$ 4.52万
依托单位：
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-01-01 至 2023-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10391316
关键词：
Affective Algorithms Behavior Behavioral Big Data Brain Brain region Cognitive Complex Conceptual Domain Data Decision Making Diagnosis Dimensions Disease Ensure Environment Factor Analysis Functional Magnetic Resonance Imaging Functional disorder Future Geometry Goals Health Hippocampal Formation Hippocampus (Brain)Impairment Individual Linear Models Link Location Maps Measures Medial Memory Mental disorders Methods Modeling Movement Neurobiology Patient Self-Report Persons Phenotype Prefrontal Cortex Process Questionnaires Role Role playing therapy Sampling Signal Transduction Social Behavior Social Functioning Social Interaction Social Power Structure Symptoms Testing Time United States Work autism spectrum disorder base behavioral study cingulate cortex cognitive neuroscience computational neuroscience computer grid computer studies digital entorhinal cortex flexibility multidimensional data neural correlate neural patterning neuromechanism novel relating to nervous system simulation social social cognition social deficits social relationships social space social structure therapeutic candidate therapeutic target tool two-dimensional

项目摘要

PROJECT SUMMARY Psychiatric disorders that feature social impairment (e.g., Autism Spectrum Disorder) pose a significant health burden in the United States. Attempts to understand the underlying neurobiology of such social impairments have largely focused on classical `social brain' networks that include regions such as the medial prefrontal cortex. However, these disorders also tend to show hippocampal dysfunction – a region not normally included in descriptions of social brain networks. This prompts the question: are social and hippocampal dysfunction linked? Social cognitive mapping, whereby social information is organized and stored in the hippocampal formation to inform flexible social decision-making, is one candidate mechanism that may unify these seemingly distinct observations. In this proposal, we will use a naturalistic choose-your-own-adventure task that probes social cognitive mapping processes. Dimensions of social power and affiliation define a `social space' within which other people are coordinates and evolving relationships are trajectories. Previous work in our lab showed that hippocampus and posterior cingulate cortex activity tracked trajectories within this space. Furthermore, the parameter estimates from the hippocampus related to self-reported social function, suggesting that this neural tracking is relevant to real-world social cognition and behavior. To characterize the role of social cognitive mapping in both normal and abnormal social cognition, this proposal will use a large, multidimensional dataset, and cutting-edge approaches to functional magnetic resonance imaging (fMRI). First, we will leverage data-driven methods on a large and diverse online sample to relate the geometry of behavior within this two-dimensional social space to the underlying structure of social dysfunction. Second, we will use ultra-high field (7T) fMRI and state-of-the-art analyses to test for specific neural signatures within the social space that are predicted by the social cognitive mapping perspective (e.g., a grid-like representation). These results will further the fields of social cognitive and computational neuroscience, by revealing the behavioral and neural correlates of evolving relationships and how they relate to social function, and by extending hippocampal function to abstract, non-spatial domains. Further, this approach will allow the role of cognitive mapping in social dysfunction to be explored, and may provide candidate therapeutic targets for psychiatric disorders.

项目摘要具有社会障碍的精神疾病（例如自闭症谱系障碍）构成了重要的美国的健康负担试图了解此类袜子的基本神经生物学障碍更大的关注于经典的“社交大脑”网络，其中包括内侧等区域但是，额叶皮层。但是，这些疾病也倾向于表现包括社交大脑网络的描述。链接的功能障碍？海马形成以告知灵活的社会决策，是一种候选机制，可以统一这些看似截然不同的观察结果。探究社会认知映射过程的任务。其他人是坐标和进化的空间是轨迹。我们的实验室表明，海马和后齿状牙皮酸盐皮质活性在该空间内追踪了轨迹。此外，来自海马的参数估计与自我报告的社会功能有关，表明神经跟踪与现实的社会认知和行为有关社会认知映射在正常和异常社会认知中的作用，该提案将使用大型，多维数据集和功能磁共振成像的尖端方法（fMRI）。我们将利用数据驱动的方法在这个二维的空间中，社会功能障碍的基本结构。超高场（7T）fMRI和最新的FES，以测试社交中特定的神经特征由社会收藏家认知映射的观点预测的空间（例如，网格般的代表）结果将通过陶醉行为来进一步进一步的社会认知和计算神经科学领域以及发展的神经相关性以及与社会功能的关系，并扩展海马功能是抽象的非空间域。在社交功能障碍中映射要探索，并可能为精神科提供候选治疗疗法疾病。