Adaptive Immune Receptor Repertoire (AIRR) Community Meeting 2021

2021 年适应性免疫受体库 (AIRR) 社区会议

• 批准号: 10391133
• 负责人: LINDSAY G. COWELL
• 金额: $ 1万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-11-22 至 2022-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10391133
• 关键词: Address; Alleles; Antibodies; Antigen Receptors; Antigens; Area; B-Cell Antigen Receptor; B-Lymphocytes; Big Data; Bioinformatics; Biological; Blast Cell; California; Cellular Immunology; Collaborations; Communication; Communities; Computational Science; Computer software; Country; Data; Data Analyses; Data Set; Databases; Diagnosis; Diagnostic; Dimensions; Disease; Educational process of instructing; Ethics; Evaluation; FAIR principles; Funding; Future; Generations; Genes; Glues; Goals; Haplotypes; Health; Heart; High-Throughput DNA Sequencing; High-Throughput Nucleotide Sequencing; Human; Immune; Immune response; Immune system; Immunity; Immunogenetics; Immunoglobulins; Immunologic Monitoring; Immunologic Receptors; Immunologics; Immunology; Individual; Institution; International; Learning; Legal; Letters; Literature; Memory; Mentors; Metadata; Mission; National Institute of Allergy and Infectious Disease; Nationalities; Nomenclature; Paper; Participant; Pattern; Persons; Plant Roots; Plasma; Poaceae; Population; Process; Progress Reports; Quality Control; Receptor Cell; Research; Research Personnel; Resources; Review Committee; Running; Sampling; Science; Scientist; Socialization; Speed; Standardization; Students; System; T-Cell Receptor; T-Lymphocyte; T-cell receptor repertoire; Technology; Therapeutic antibodies; Tissues; Travel; Underrepresented Populations; United States National Institutes of Health; Universities; Validation; Variant; Visualization; Woman; Work; analysis pipeline; base; cancer immunotherapy; career; computerized tools; data repository; data sharing; data standards; deep learning; diversity and inclusion; experience; experimental study; frontier; immunoglobulin B; interest; interoperability; meetings; member; men; method development; multidisciplinary; open data; outreach; posters; recruit; response; senior faculty; skills; symposium; vaccine development; vaccine-induced antibodies; virtual; volunteer; webinar; working group

The central aim of this re-submission is to convene a meeting of the Adaptive Immune Receptor Repertoire Community (AIRR-C) in December of 2021. The PI of the proposal, Dr. Lindsay Cowell, who is now the Chair of the AIRR-C's Executive Sub-committee (SC). The submission of this proposal was undertaken in close collaboration with the Members of the AIRR-C Meetings SC. A given AIRR comprises the antigen receptors on a population of T cells (TcRs), B cells (BcRs) and/or the antibodies (Abs) secreted by plasma- blasts and cells, and reflects the clonal composition of such populations. With the advent of high-throughput DNA sequencing, the AIRR-C emerged as a grass roots, multidisciplinary and inclusive scientific community dedicated to the development of methods and standards for the generation, analysis, storage and sharing of AIRR sequencing (AIRR-seq) data and its associated metadata, following FAIR-data principles and open- science practices. The 2020 meeting is the fifth AIRR-C meeting and will be held at Scripps Research in partnership with our Scripps host, Dr. Dennis Burton, and next door at the La Jolla Hilton hotel, on 8-11 December 2021. The Members of the AIRR-C Meetings SC comprise 3 women and 3 men at all stages of career from grad student to full professor, and from 6 different countries; their immunological expertise spans a wide range from immunogenetics to cellular immunology, bioinformatics and computational sciences. Together, they have prepared an exciting meeting with two Scientific sessions presented by 8 top scientists in their field, covering current advances made with AIRR-seq data in the Basic and Biomedical Sciences. And, to advance the AIRR-C's goals, two Challenge Sessions are planned to explore “Sustainability for the AIRR-C and its Mission” (a panel discussion) and the relevance of AIRR-seq data to “Systems Immunology” (with presentations by 4 outstanding scientists). As detailed in the proposal and letters of support, the meeting will provide opportunities for investigators and trainees to network, participate in AIRR-C Working Groups and learn in hands-on tutorials, poster presentations and platform presentations and advance the field of immune-repertoire profiling. The AIRR-C Meetings and Executive SCs have taken NIH's new requirement for a diversity plan to heart, and will commit the requested funds to providing travel and lodging support for two types of attendees from under-represented groups: (i) early-career scientists and their trainees, and (ii) attendees from local universities that support under-represented students (e.g., Charles Drew University in LA, the local Cal State Universities in Southern California). This plan includes outreach to these institutions, and a description for how early-career scientists, trainees and other students could become active participants within our scientific networks as members of our 7 Working Groups and/or 2 SCs. This conference is meant to provide a deep learning experience for all and a chance to strengthen our scientific networks; this is a proven approach to stimulating collaborative advances in biomedicine.

这次重新提交的中心目的是召开适应性免疫受体库会议 2021 年 12 月社区（AIRR-C）。该提案的 PI Lindsay Cowell 博士，现在是 AIRR-C 执行小组委员会 (SC) 主席 该提案于 2017 年提交。 与 AIRR-C 会议 SC 成员密切合作。特定的 AIRR 包含抗原。 T 细胞 (TcR)、B 细胞 (BcR) 和/或血浆分泌的抗体 (Ab) 群体上的受体 原始细胞和细胞，并反映了随着高通量的出现，这些群体的克隆组成。 DNA 测序、AIRR-C 成为一个草根、多学科和包容性的科学团体 致力于开发生成、分析、存储和共享的方法和标准 AIRR 测序 (AIRR-seq) 数据及其相关元数据，遵循公平数据原则和开放式 2020 年会议是第五次 AIRR-C 会议，将于 2020 年在斯克里普斯研究中心举行。 与我们的斯克里普斯主持人 Dennis Burton 博士合作，并于 8 月 11 日在隔壁的拉霍亚希尔顿酒店 2021 年 12 月。AIRR-C 会议 SC 的成员包括各阶段的 3 名女性和 3 名男性 从研究生到教授的职业生涯，以及来自 6 个不同国家的免疫学专业知识； 涵盖从免疫遗传学到细胞免疫学、生物信息学和计算的广泛领域 他们共同准备了一场激动人心的会议，其中包括由 8 位顶尖人士主持的两场科学会议。 各自领域的科学家，涵盖了 AIRR-seq 数据在基础和生物医学领域的最新进展 而且，为了推进 AIRR-C 的目标，计划举办两次挑战会议来探索。 “AIRR-C 及其使命的可持续性”（小组讨论）以及 AIRR-seq 数据与 “系统免疫学”（由 4 位杰出科学家进行演讲），详见提案和 支持信，会议将为调查人员和受训人员提供建立网络、参与的机会 参加 AIRR-C 工作组并通过实践教程、海报演示和平台演示进行学习 AIRR-C 会议和执行 SC 已采取行动，推动免疫库分析领域的发展。 NIH 对多样性计划的新要求要牢记在心，并将把所要求的资金用于提供旅行 以及为来自代表性不足群体的两类与会者提供住宿支持：(i) 早期职业科学家 及其学员，以及 (ii) 来自支持代表性不足学生的当地大学的参加者（例如， 洛杉矶的查尔斯·德鲁大学、南加州当地的加州州立大学 该计划包括。 向这些机构进行推广，并描述早期职业科学家、受训人员和其他学生如何 可以作为我们 7 个工作组的成员成为我们科学网络的积极参与者和/或 2 SC 本次会议旨在为所有人提供深度学习体验和加强的机会。 我们的科学网络；这是刺激生物医学合作进步的行之有效的方法。