Adaptive Immune Receptor Repertoire (AIRR) Community Meeting 2021

2021 年适应性免疫受体库 (AIRR) 社区会议

• 批准号: 10391133
• 负责人: LINDSAY G. COWELL
• 金额: $ 1万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-11-22 至 2022-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10391133
• 关键词: Address; Alleles; Antibodies; Antigen Receptors; Antigens; Area; B-Cell Antigen Receptor; B-Lymphocytes; Big Data; Bioinformatics; Biological; Blast Cell; California; Cellular Immunology; Collaborations; Communication; Communities; Computational Science; Computer software; Country; Data; Data Analyses; Data Set; Databases; Diagnosis; Diagnostic; Dimensions; Disease; Educational process of instructing; Ethics; Evaluation; FAIR principles; Funding; Future; Generations; Genes; Glues; Goals; Haplotypes; Health; Heart; High-Throughput DNA Sequencing; High-Throughput Nucleotide Sequencing; Human; Immune; Immune response; Immune system; Immunity; Immunogenetics; Immunoglobulins; Immunologic Monitoring; Immunologic Receptors; Immunologics; Immunology; Individual; Institution; International; Learning; Legal; Letters; Literature; Memory; Mentors; Metadata; Mission; National Institute of Allergy and Infectious Disease; Nationalities; Nomenclature; Paper; Participant; Pattern; Persons; Plant Roots; Plasma; Poaceae; Population; Process; Progress Reports; Quality Control; Receptor Cell; Research; Research Personnel; Resources; Review Committee; Running; Sampling; Science; Scientist; Socialization; Speed; Standardization; Students; System; T-Cell Receptor; T-Lymphocyte; T-cell receptor repertoire; Technology; Therapeutic antibodies; Tissues; Travel; Underrepresented Populations; United States National Institutes of Health; Universities; Validation; Variant; Visualization; Woman; Work; analysis pipeline; base; cancer immunotherapy; career; computerized tools; data repository; data sharing; data standards; deep learning; diversity and inclusion; experience; experimental study; frontier; immunoglobulin B; interest; interoperability; meetings; member; men; method development; multidisciplinary; open data; outreach; posters; recruit; response; senior faculty; skills; symposium; vaccine development; vaccine-induced antibodies; virtual; volunteer; webinar; working group; Address; Alleles; Antibodies; Antigen Receptors; Antigens; Area; B-Cell Antigen Receptor; B-Lymphocytes; Big Data; Bioinformatics; Biological; Blast Cell; California; Cellular Immunology; Collaborations; Communication; Communities; Computational Science; Computer software; Country; Data; Data Analyses; Data Set; Databases; Diagnosis; Diagnostic; Dimensions; Disease; Educational process of instructing; Ethics; Evaluation; FAIR principles; Funding; Future; Generations; Genes; Glues; Goals; Haplotypes; Health; Heart; High-Throughput DNA Sequencing; High-Throughput Nucleotide Sequencing; Human; Immune; Immune response; Immune system; Immunity; Immunogenetics; Immunoglobulins; Immunologic Monitoring; Immunologic Receptors; Immunologics; Immunology; Individual; Institution; International; Learning; Legal; Letters; Literature; Memory; Mentors; Metadata; Mission; National Institute of Allergy and Infectious Disease; Nationalities; Nomenclature; Paper; Participant; Pattern; Persons; Plant Roots; Plasma; Poaceae; Population; Process; Progress Reports; Quality Control; Receptor Cell; Research; Research Personnel; Resources; Review Committee; Running; Sampling; Science; Scientist; Socialization; Speed; Standardization; Students; System; T-Cell Receptor; T-Lymphocyte; T-cell receptor repertoire; Technology; Therapeutic antibodies; Tissues; Travel; Underrepresented Populations; United States National Institutes of Health; Universities; Validation; Variant; Visualization; Woman; Work; analysis pipeline; base; cancer immunotherapy; career; computerized tools; data repository; data sharing; data standards; deep learning; diversity and inclusion; experience; experimental study; frontier; immunoglobulin B; interest; interoperability; meetings; member; men; method development; multidisciplinary; open data; outreach; posters; recruit; response; senior faculty; skills; symposium; vaccine development; vaccine-induced antibodies; virtual; volunteer; webinar; working group

The central aim of this re-submission is to convene a meeting of the Adaptive Immune Receptor Repertoire Community (AIRR-C) in December of 2021. The PI of the proposal, Dr. Lindsay Cowell, who is now the Chair of the AIRR-C's Executive Sub-committee (SC). The submission of this proposal was undertaken in close collaboration with the Members of the AIRR-C Meetings SC. A given AIRR comprises the antigen receptors on a population of T cells (TcRs), B cells (BcRs) and/or the antibodies (Abs) secreted by plasma- blasts and cells, and reflects the clonal composition of such populations. With the advent of high-throughput DNA sequencing, the AIRR-C emerged as a grass roots, multidisciplinary and inclusive scientific community dedicated to the development of methods and standards for the generation, analysis, storage and sharing of AIRR sequencing (AIRR-seq) data and its associated metadata, following FAIR-data principles and open- science practices. The 2020 meeting is the fifth AIRR-C meeting and will be held at Scripps Research in partnership with our Scripps host, Dr. Dennis Burton, and next door at the La Jolla Hilton hotel, on 8-11 December 2021. The Members of the AIRR-C Meetings SC comprise 3 women and 3 men at all stages of career from grad student to full professor, and from 6 different countries; their immunological expertise spans a wide range from immunogenetics to cellular immunology, bioinformatics and computational sciences. Together, they have prepared an exciting meeting with two Scientific sessions presented by 8 top scientists in their field, covering current advances made with AIRR-seq data in the Basic and Biomedical Sciences. And, to advance the AIRR-C's goals, two Challenge Sessions are planned to explore “Sustainability for the AIRR-C and its Mission” (a panel discussion) and the relevance of AIRR-seq data to “Systems Immunology” (with presentations by 4 outstanding scientists). As detailed in the proposal and letters of support, the meeting will provide opportunities for investigators and trainees to network, participate in AIRR-C Working Groups and learn in hands-on tutorials, poster presentations and platform presentations and advance the field of immune-repertoire profiling. The AIRR-C Meetings and Executive SCs have taken NIH's new requirement for a diversity plan to heart, and will commit the requested funds to providing travel and lodging support for two types of attendees from under-represented groups: (i) early-career scientists and their trainees, and (ii) attendees from local universities that support under-represented students (e.g., Charles Drew University in LA, the local Cal State Universities in Southern California). This plan includes outreach to these institutions, and a description for how early-career scientists, trainees and other students could become active participants within our scientific networks as members of our 7 Working Groups and/or 2 SCs. This conference is meant to provide a deep learning experience for all and a chance to strengthen our scientific networks; this is a proven approach to stimulating collaborative advances in biomedicine.

这种重新提出的核心目的是召集自适应免疫受体曲目的会议 社区（AIRR-C）在2021年12月。提案的PI Lindsay Cowell博士现在是 AIRR-C执行小组委员会（SC）主席。该提议的提交是在 与AIRR-C会议的成员密切合作。给定的AIRR包括抗原 T细胞群（TCR），B细胞（BCR）和/或血浆分泌的抗体（ABS）的受体 爆炸和细胞，反映了此类人群的克隆组成。随着高通量的冒险 DNA测序，AIRR-C作为基层，多学科和包容性科学界出现 致力于制定生成，分析，存储和共享的方法和标准 AIRR测序（AIRR-SEQ）数据及其相关的元数据，遵循公平的原则和开放 科学实践。 2020年会议是第五届Airr-C会议，将在Scripps Research举行。 与我们的Scripps主持人Dennis Burton博士和La Jolla Hilton Hotel的隔壁合作，8-11 2021年12月。AIRR-C会议的成员SC在各个阶段建立了3名妇女和3名男子 从研究生到正教授的职业，以及来自6个不同国家的职业；他们的免疫学专业知识 跨越从免疫遗传学到细胞免疫学，生物信息学和计算的广泛范围 科学。他们一起准备了一次激动人心的会议，并举行了两个由8个顶部提出的科学会议 其领域的科学家涵盖了基本和生物医学中用AIRR-SEQ数据取得的当前进步 科学。而且，为了促进AIRR-C的目标，计划探索两个挑战会议 “ AIRR-C及其使命的可持续性”（小组讨论）以及Airr-Seq数据与 “系统免疫学”（由4位杰出科学家演讲）。提案中详细介绍 支持信，会议将为调查人员和学员提供网络的机会，参与 在AIRR-C工作组中，并在动手教程，海报演示和平台演示文稿中学习 并推进免疫静态分析的领域。 AIRR-C会议和执行SC已参加 NIH对多元化计划的新要求，并将投入要求提供旅行的资金 并为来自代表性不足的群体的两种类型的与会者提供支持：（i）早期职业科学家 以及他们的受训者，以及（ii）来自当地大学的参与者，这些大学支持代表性不足的学生（例如， 查尔斯·德鲁大学（Charles Drew University）位于洛杉矶，南加州当地的加利福尼亚州立大学）。该计划包括 向这些机构推广，以及对早期科学家，学员和其他学生的描述 作为我们的7个工作组成员和/或，可以成为我们科学网络中的积极参与者 2 scs。这次会议旨在为所有人提供深入的学习体验，并有机会加强 我们的科学网络；这是一种刺激生物医学协作进展的事实证明的方法。