Partnership for Prevention of HPV-Associated Cancers in People Living with HIV: Brazil, Mexico, and Puerto Rico

艾滋病毒感染者预防 HPV 相关癌症的伙伴关系：巴西、墨西哥和波多黎各

• 批准号: 10471206
• 负责人: Anna R. Giuliano
• 金额: --
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-20 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10471206
• 关键词: AIDS/HIV problem; Address; Brazil; Caribbean region; Cervical; Cervical Cancer Screening; Clinical; Clinical Trials; Collaborations; Conduct Clinical Trials; Country; DNA Methylation; Disease; Faculty; Future; Future Generations; Gender; Goals; HIV; HPV oropharyngeal cancer; HPV-High Risk; Human Papilloma Virus Vaccine; Human Papilloma Virus-Related Malignant Neoplasm; Human Papillomavirus; Human papilloma virus infection; Individual; Institution; Intervention; Investigation; Knowledge; Latin America; Learning; Licensure; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Mentors; Mentorship; Methods; Methylation; Mexico; Morbidity - disease rate; Multi-Institutional Clinical Trial; Peer Review; Persons; Positioning Attribute; Prevention; Prospective cohort study; Publications; Puerto Rico; Reproducibility; Research; Research Infrastructure; Research Personnel; Research Priority; Site; Testing; Training; Training Programs; Triage; United States National Institutes of Health; Vaccination; Woman; cancer prevention; cervical cancer prevention; design; effective intervention; experience; high risk population; improved; innovation; malignant oropharynx neoplasm; men; mortality; novel; policy recommendation; prevent; preventive intervention; programs; screening program; therapeutic vaccine; vaccine trial

OVERALL ABSTRACT The Partnership Center, entitled Multinational Partnership to Prevent HPV-Associated Cancer in People Living with HIV: Brazil, Mexico, Puerto Rico (PHAC-BMPR), will bring together experienced research sites and world- renowned HPV and HIV researchers to build on established collaborations to conduct clinical trials on prevention of HPV-associated cancers among people living with HIV. This will provide an invaluable opportunity for newer investigators from Latin America/Caribbean (LAC) to participate in and learn from high- quality research. PHAC-BMPR will focus on two HPV-associated cancers that result in substantial morbidity and mortality: HPV- associated oropharyngeal cancer (HPV-OPC) and cervical cancer. These scientific goals are aligned with the goals of the US National Institutes of Health for research priorities for people living with HIV/AIDS as well as in country and regional goals to reduce cancer morbidity and mortality. At the end of this project, we hope to make advances that will highly impact prevention of HPV-associated cancers in people living with HIV and contribute to the global goal of cervical cancer elimination and reduction of other HPV-associated cancers such as oropharyngeal cancer (OPC).

总体摘要 合作中心，题为“预防人类 HPV 相关癌症的多国合作” 艾滋病毒：巴西、墨西哥、波多黎各 (PHAC-BMPR)，将汇集经验丰富的研究地点和世界各地 著名的 HPV 和 HIV 研究人员将在已建立的合作基础上开展临床试验 预防艾滋病毒感染者中的 HPV 相关癌症。这将提供无价的 为来自拉丁美洲/加勒比地区 (LAC) 的新研究者提供参与高水平研究并向其学习的机会 质量研究。 PHAC-BMPR 将重点关注两种导致大量发病率和死亡率的 HPV 相关癌症：HPV- 相关口咽癌（HPV-OPC）和宫颈癌。这些科学目标与 美国国立卫生研究院针对艾滋病毒/艾滋病患者以及艾滋病毒/艾滋病患者的研究重点的目标 降低癌症发病率和死亡率的国家和区域目标。在这个项目结束时，我们希望 取得的进展将对艾滋病毒感染者预防 HPV 相关癌症产生重大影响， 为消除宫颈癌和减少其他 HPV 相关癌症（例如 如口咽癌（OPC）。