Tumor Microenvironment Research Program

肿瘤微环境研究计划

基本信息

批准号：
10456704
负责人：
Pamela K Kreeger
金额：
$ 8.35万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-04-25 至 2023-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10456704
关键词：
Affect Area Behavior Biocompatible Materials Biological Markers Biological Models Biomedical Engineering Blood Vessels Breast Cell Adhesion Cell Communication Cell Proliferation Cell-Cell Adhesion Cells Chronic Collaborations Collagen Complex Comprehensive Cancer Center Computer Analysis Computer Models Deposition Development Direct Costs Education and Outreach Elements Engineering Environment Epidermis Event Extracellular Matrix Feedback Fostering Funding Goals Grant Growth Growth Factor Immune Immune system Immunotherapy Individual Infiltration Inflammation Institution Investigation Knowledge Lead Light Malignant Neoplasms Malignant neoplasm of ovary Measures Metabolism Microfluidics Mission Modeling Multiple Myeloma Neoplasm Metastasis Oncogenic Outcome Study Paracrine Communication Participant Peer Review Phenotype Play Positioning Attribute Publications Publishing Research Research Personnel Role Scientist Signal Transduction Site Stromal Cells Structure System Systems Development Therapeutic Time Tissues Translating Tumor Angiogenesis Tumor Cell Migration Zebrafish anticancer research cancer cell cancer initiation cancer type cell behavior cytokine density imaging modality in vitro Model in vivo macrophage member migration model development neoplastic cell neutrophil novel patient response predictive marker programs recruit trafficking treatment response tumor tumor microenvironment tumor progression tumorigenesis

Affect Area Behavior Biocompatible Materials Biological Markers Biological Models Biomedical Engineering Blood Vessels Breast Cell Adhesion Cell Communication Cell Proliferation Cell-Cell Adhesion Cells Chronic Collaborations Collagen Complex Comprehensive Cancer Center Computer Analysis Computer Models Deposition Development Direct Costs Education and Outreach Elements Engineering Environment Epidermis Event Extracellular Matrix Feedback Fostering Funding Goals Grant Growth Growth Factor Immune Immune system Immunotherapy Individual Infiltration Inflammation Institution Investigation Knowledge Lead Light Malignant Neoplasms Malignant neoplasm of ovary Measures Metabolism Microfluidics Mission Modeling Multiple Myeloma Neoplasm Metastasis Oncogenic Outcome Study Paracrine Communication Participant Peer Review Phenotype Play Positioning Attribute Publications Publishing Research Research Personnel Role Scientist Signal Transduction Site Stromal Cells Structure System Systems Development Therapeutic Time Tissues Translating Tumor Angiogenesis Tumor Cell Migration Zebrafish anticancer research cancer cell cancer initiation cancer type cell behavior cytokine density imaging modality in vitro Model in vivo macrophage member migration model development neoplastic cell neutrophil novel patient response predictive marker programs recruit trafficking treatment response tumor tumor microenvironment tumor progression tumorigenesis

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项目摘要

UWCCC Tumor Microenvironment (TM) Program Summary Co-Leaders: Patricia Keely and David Beebe PROJECT SUMMARY/ABSTRACT Tumors are complex systems composed of tumor cells, stromal cells, soluble factors, and the extracellular matrix (ECM); together, these components constitute the tumor microenvironment. While cancer research has focused historically on studying and treating the tumor cell, it is now clear that the other components of the tumor microenvironment are active participants in tumor progression. For example, growth factors secreted by tumor cells attract immune cells into the tumor microenvironment; these immune cells in turn provide cytokines and other factors that stimulate stromal cell deposition and remodeling of ECM, which feedback to influence tumor cell behavior. Although the tumor microenvironment is undoubtedly important in the progression of several types of cancer, therapeutic approaches targeted against the microenvironment remain rare, in part, because knowledge in this area is insufficient. Therefore, it is the mission of the Tumor Microenvironment (TM) Program to identify microenvironmental changes that occur during tumorigenesis and analyze how the interactions between the tumor cell and microenvironmental components affect tumor formation, growth, progression, and ultimately metastasis. To accomplish these goals, the TM program fosters collaborations between its 32 members from 17 departments - basic scientists, clinicians, and bioengineers who specialize in the development of systems that mimic the in vivo environment and computational modeling of systems-level behaviors. TM program research is organized into three thematic areas: 1) Extracellular Matrix, 2) Engineering Approaches, and 3) Immune Interactions. Program members were supported by $3.0 million direct costs in NCI-funding and $10.6 million direct costs in total peer-reviewed cancer-related support, and were highly productive with 494 publications during the course of the last grant. Of these publications, 13% were intra- programmatic collaborations and 24% were inter-programmatic collaborations. In the year 2016 alone, nearly 50% of publications were collaborative with other institutions. Through these research efforts, members of the TM program are identifying new biomarkers and therapeutic approaches.

UWCCC肿瘤微环境（TM）计划摘要共同领导者：帕特里夏·基利（Patricia Keely）和大卫·比贝（David Beebe）项目摘要/摘要肿瘤是由肿瘤细胞，基质细胞，可溶性因子和细胞外的复杂系统矩阵（ECM）;这些成分共同构成了肿瘤微环境。癌症研究有历史上专注于研究和治疗肿瘤细胞，现在很明显，肿瘤微环境是肿瘤进展中的积极参与者。例如，增长因素分泌肿瘤细胞吸引免疫细胞进入肿瘤微环境；这些免疫细胞又提供了细胞因子以及刺激基质细胞沉积和ECM重塑的其他因素，这些因素反馈会影响肿瘤细胞行为。尽管肿瘤微环境无疑在进展中很重要针对微环境的几种类型的癌症，针对微环境的治疗方法仍然很少因为该领域的知识不足。因此，这是肿瘤微环境的任务（TM）识别肿瘤发生过程中发生的微环境变化的程序并分析了如何肿瘤细胞与微环境成分之间的相互作用会影响肿瘤形成，生长，进展，最终转移。为了实现这些目标，TM计划促进了合作在17个部门的32名成员之间 - 专门研究的基础科学家，临床医生和生物工程师模拟体内环境和系统级计算建模的系统的开发行为。 TM计划研究分为三个主题领域：1）细胞外基质，2）工程方法和3）免疫相互作用。计划成员得到300万美元的直接费用的支持 NCI资助和1,060万美元的直接成本与同行评审的癌症相关支持，并且非常高在上一笔赠款过程中，有494个出版物的生产力。在这些出版物中，有13％是内部的程序化协作和24％是程序间合作。仅在2016年，几乎 50％的出版物与其他机构合作。通过这些研究工作， TM计划正在确定新的生物标志物和治疗方法。