Center for Adaptive Neurotechnologies

自适应神经技术中心

• 批准号: 10456334
• 负责人: Jonathan Rickel Wolpaw
• 金额: $ 107.57万
• 依托单位: ALBANY RESEARCH INSTITUTE, INC.
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-10 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10456334
• 关键词: Achievement; Advisory Committees; Affect; Amaze; Area; Behavior; Brain; Cerebral Palsy; Clinical; Collaborations; Course Content; Development; Disease; Educational workshop; Electric Stimulation; Electrodes; Engineering; Ensure; Etiology; Functional disorder; Goals; Grant; Impairment; Industry; Institution; International; Intervention; Logistics; Maps; Methods; Minor; Molecular Biology; Nervous System Physiology; Nervous system structure; Neuraxis; Neuromuscular Diseases; Neuronal Plasticity; Operant Conditioning; Outcome; Persons; Protocols documentation; Rattus; Recovery; Recovery of Function; Reporting; Research Personnel; Scientist; Services; Site; Spinal cord injury; Stroke; Structure; Sum; Support System; System; Technology; Therapeutic; Therapeutic Studies; Time; Training; Training Support; Translating; United States; Work; base; clinical translation; design; dissemination strategy; functional restoration; imaging modality; improved; improved functioning; injury recovery; insight; nervous system disorder; neurotechnology; new technology; novel; novel therapeutics; spinal reflex; success; technology research and development; web site; wireless implant

NCAN Summary Engineers and scientists at the National Center for Adaptive Neurotechnologies (NCAN) are creating technologies that can guide CNS plasticity to enhance recovery for people with spinal cord injury, stroke, or other neuromuscular disorders. NCAN is producing new insights and novel therapies and disseminating them to engineers, scientists, and clinicians everywhere. This renewal application proposes to enhance NCAN technologies, apply them to critical problems, hasten their clinical translation, and increase their wider impact. Aim 1 will develop a wholly implanted wireless system for long-term 24/7 interactive studies in freely moving rats. It will use this new system for the first study of the molecular biology underlying spinal reflex operant conditioning, a promising new therapy that can enhance recovery after spinal cord injury or other disorders. This novel system will support many kinds of long-term real-time interactive interventions for NCAN and for other researchers. Aim 2 will develop a robust clinical system that supports a wide variety of protocols designed to target beneficial plasticity to key CNS sites and is suitable for widespread clinical use. It will optimize this new system in collaboration with clinical therapists and provide it for therapeutic studies focused on spinal cord injury, cerebral palsy, and stroke. Aim 3 will develop a clinically practical system that uses electrical stimulation via electrocorticographic/stereoencephalographic electrodes to map brain networks, define causality between areas, and ultimately, to target plasticity that restores function impaired by stroke or other disorders. It will thereby create a new imaging modality that can reveal point-to-point functional connections in the brain, relate them to behavior, and enable their therapeutic modulation. Aim 4 will provide training in and promote dissemination of NCAN neurotechnologies. It will enhance NCAN's 3-week short course curriculum, continue to offer many topic-specific workshops in appropriate venues, and provide materials and guidance that enable other institutions to create their own topic-specific courses. It will disseminate and support training materials and technologies through the NCAN website and other mechanisms. Aim 5 comprises the administration that supports all NCAN activities. This new grant period will include further development of major successes of the first grant period, initiation of new technologies and novel therapeutic protocols, strong synergistic interactions among the Aims, intensive collaborations with industry, and growing focus on clinical translation of NCAN technologies and protocols. In summary, NCAN will continue to create novel neurotechnologies, define their mechanisms, translate them into widespread use, and provide training and dissemination that enable and encourage other scientists, engineers, and clinicians to join in developing these technologies and applying them to major scientific and clinical problems. Thus, NCAN will continue to perform, encourage, and enable studies that elucidate CNS function and dysfunction, and that realize effective new therapies for devastating neurological disorders.

NCAN 总结 国家自适应神经技术中心 (NCAN) 的工程师和科学家正在创造技术 可以指导中枢神经系统可塑性，以促进脊髓损伤、中风或其他神经肌肉患者的康复 失调。 NCAN 正在产生新的见解和新颖的疗法，并将其传播给工程师、科学家、 以及各地的临床医生。该更新申请旨在增强 NCAN 技术，将其应用于 关键问题，加速其临床转化，并扩大其更广泛的影响。 Aim 1将开发一种完全植入的无线系统，用于自由移动的长期24/7交互式研究 老鼠。它将使用这个新系统首次研究脊髓反射操作的分子生物学 调理，一种有前途的新疗法，可以促进脊髓损伤或其他疾病后的恢复。这 新颖的系统将支持 NCAN 和其他多种长期实时交互干预 研究人员。目标 2 将开发一个强大的临床系统，支持多种协议，旨在 针对关键中枢神经系统部位的有益可塑性，适合广泛的临床使用。它将优化这个新的 与临床治疗师合作的系统，并将其用于针对脊髓损伤的治疗研究， 脑瘫、中风。目标 3 将开发一种临床实用系统，通过电刺激 皮质电图/立体脑电图电极可绘制大脑网络，定义区域之间的因果关系， 最终，目标是恢复因中风或其他疾病而受损的功能的可塑性。它将从而创造 一种新的成像方式，可以揭示大脑中点对点的功能连接，并将它们与行为联系起来， 并启用它们的治疗调节。目标 4 将提供 NCAN 培训并促进传播 神经技术。它将增强 NCAN 为期 3 周的短期课程课程，继续提供许多特定主题的课程 在适当的场所举办研讨会，并提供材料和指导，使其他机构能够创建自己的 自己的特定主题课程。它将通过 NCAN 传播和支持培训材料和技术 网站和其他机制。目标 5 包括支持所有 NCAN 活动的管理。 这个新的资助期将包括进一步发展第一个资助期的重大成功，启动 新技术和新颖的治疗方案，目标之间强大的协同相互作用，密集 与行业的合作，以及日益关注 NCAN 技术和协议的临床转化。 总之，NCAN 将继续创造新颖的神经技术，定义其机制，并将其转化为 广泛使用，并提供培训和传播，以帮助和鼓励其他科学家、工程师、 和临床医生共同开发这些技术并将其应用于重大科学和临床问题。 因此，NCAN 将继续开展、鼓励和开展阐明中枢神经系统功能和功能障碍的研究， 并实现针对破坏性神经系统疾病的有效新疗法。