The Changing COVID-19 Landscape: A Feasibility Study to Capture Momentary Residential Environmental Exposures and Asthma Sypmtoms in Adults

不断变化的 COVID-19 形势：捕捉瞬时居住环境暴露和成人哮喘症状的可行性研究

• 批准号: 10369705
• 负责人: Kamal M Eldeirawi
• 金额: $ 21.97万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-03-15 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10369705
• 关键词: 2019-nCoV; Address; Adolescent; Adult; Advocate; Affect; Air; Air Pollutants; Area; Asthma; Behavior; COVID-19; COVID-19 impact; COVID-19 pandemic; COVID-19 prevention; Cellular Phone; Chemical Exposure; Chemicals; Chicago; Child; Communicable Diseases; Communities; Complex; Computer software; Data; Data Collection; Data Reporting; Death Rate; Diagnosis; Direct Costs; Disease Outbreaks; Disinfectants; Ecological momentary assessment; Economic Burden; Elderly; Environmental Exposure; Environmental Impact; Environmental Monitoring; Environmental Risk Factor; Exposure to; Face; Facilities and Administrative Costs; Feasibility Studies; Frequencies; Future; Goals; Hand; Home; Home environment; Hour; Household; Housing; Hygiene; Individual; Indoor Air Quality; Indoor environment; Intervention; Measures; Midwestern United States; Monitor; Notification; Nurses; Participant; Particulate; Particulate Matter; Patient Self-Report; Physicians; Population; Preventive measure; Public Health; Pulmonary Function Test/Forced Expiratory Volume 1; Quality-Adjusted Life Years; Readiness; Recommendation; Reporting; Research; Respiratory Disease; Risk Factors; Risk Reduction; Schedule; Scientist; Self Management; Shelter facility; Spirometry; Surveys; Symptoms; Time; United States; Virus; Virus Diseases; age group; asthma exacerbation; base; chronic respiratory disease; cost; design; economic impact; environmental tobacco smoke; experience; fine particles; health economics; improved; innovation; member; pandemic coronavirus; pandemic disease; pollutant; pulmonary function; recruit; sensor; usability; volatile organic compound; willingness; 2019-nCoV; Address; Adolescent; Adult; Advocate; Affect; Air; Air Pollutants; Area; Asthma; Behavior; COVID-19; COVID-19 impact; COVID-19 pandemic; COVID-19 prevention; Cellular Phone; Chemical Exposure; Chemicals; Chicago; Child; Communicable Diseases; Communities; Complex; Computer software; Data; Data Collection; Data Reporting; Death Rate; Diagnosis; Direct Costs; Disease Outbreaks; Disinfectants; Ecological momentary assessment; Economic Burden; Elderly; Environmental Exposure; Environmental Impact; Environmental Monitoring; Environmental Risk Factor; Exposure to; Face; Facilities and Administrative Costs; Feasibility Studies; Frequencies; Future; Goals; Hand; Home; Home environment; Hour; Household; Housing; Hygiene; Individual; Indoor Air Quality; Indoor environment; Intervention; Measures; Midwestern United States; Monitor; Notification; Nurses; Participant; Particulate; Particulate Matter; Patient Self-Report; Physicians; Population; Preventive measure; Public Health; Pulmonary Function Test/Forced Expiratory Volume 1; Quality-Adjusted Life Years; Readiness; Recommendation; Reporting; Research; Respiratory Disease; Risk Factors; Risk Reduction; Schedule; Scientist; Self Management; Shelter facility; Spirometry; Surveys; Symptoms; Time; United States; Virus; Virus Diseases; age group; asthma exacerbation; base; chronic respiratory disease; cost; design; economic impact; environmental tobacco smoke; experience; fine particles; health economics; improved; innovation; member; pandemic coronavirus; pandemic disease; pollutant; pulmonary function; recruit; sensor; usability; volatile organic compound; willingness

ABSTRACT The global pandemic of coronavirus 2019 (COVID-19) is a substantial cause for concern among individuals with chronic respiratory diseases, including those with asthma. It is estimated that more than 60% of adults with asthma have uncontrolled symptoms and this represents a substantial health and economic impact. Compared to children, adults are nearly five times more likely to die from asthma and the asthma-related death rate is highest among those 65 years and older. Viral infections are a prominent risk factor for asthma exacerbation and, thus, SARS-CoV-2, the virus responsible for COVID-19, is cause for alarm among those diagnosed with asthma. Sheltering-in-place orders and recommendations, physical distancing, wearing face coverings, hand hygiene, and increased cleaning and disinfecting are primary COVID-19 preventative measures advocated. The effects of home-based strategies to prevent COVID-19, specifically increased residential exposure to cleaning/disinfecting agents and particulates on adults with asthma is unknown. Our long term goal is to characterize the impact of COVID-19 on existing asthma risk factors so as to develop tailored, home-based asthma interventions that adequately acknowledge COVID-19 and are responsive to the changing home environment and home routines resulting from this pandemic. The aims of this study are: 1) determine the feasibility and usability of: (a) ecological momentary assessment (EMA) to assess self-report residential environmental exposures and asthma symptoms, (b) home monitoring of objective environmental exposures (total volatile organic compounds [VOCs], particulates [PM2.5]), and lung function (home spirometry); 2a) assess the frequency and degree of residential environmental exposures (e.g., disinfectants/cleaners, second-hand smoke) via (a) self-reported data, and (b) home monitoring objective measures, 2b) assess the level of asthma control as indicated by self-reported asthma symptoms and lung function; and 3) explore associations of self-reported and objective measures of residential environmental exposures with self-reported and objective measures of asthma control. We will recruit 50 adults with asthma who completed our ongoing online COVID-19 and asthma survey, indicated willingness to be contacted for future studies, reported high use of disinfectant/cleaning products, and have not-well controlled asthma. Participants will receive an indoor air quality monitor and a home spirometer to measure VOCs, PM2.5, and FEV1% respectively. EMA will be collected using a personal smartphone and EMA software platform. Participants’ will be sent scheduled and random EMA notifications to assess asthma symptoms, environmental exposures, lung function, and mitigation strategies. After the 14-day data collection period, participants will respond to survey items related acceptability, appropriateness, and feasibility. Findings from this feasibility study will support a powered study to address the impact of environmental exposures related to COVID-19 and to enhance preparedness for future infectious disease outbreaks by developing innovative intervention strategies for those with asthma.

抽象的 2019年冠状病毒的全球大流行（Covid-19）是个人关注的重要原因 患有慢性呼吸道疾病，包括患有哮喘的疾病。据估计，超过60％的成年人 哮喘具有不受控制的症状，这代表了重大的健康和经济影响。 与儿童相比，成年人死于哮喘和与哮喘有关的可能性几乎是五倍 在65岁以上的死亡率最高。病毒感染是重要的风险因素 哮喘加剧，因此，导致Covid-19的病毒SARS-COV-2是引起警报 那些被诊断为哮喘的人。庇护订单和建议，身体距离，穿着 面部覆盖物，手工卫生以及清洁和消毒的增加是主要的covid-19 提倡的措施。基于家庭的策略防止Covid-19的影响，特别增加了 住宅暴露于清洁/消毒剂并参与哮喘的成年人。我们的 长期目标是表征COVID-19对现有哮喘风险因素的影响，以发展 量身定制的，基于家庭的哮喘干预措施，充分承认Covid-19，并对 改变家庭环境和家庭习惯，导致了这一大流行。这项研究的目的是：1） 确定：（a）评估自我报告的生态瞬时评估（EMA）的可行性和可用性 住宅环境暴露和哮喘症状，（b）客观环境的家庭监测 暴露（总挥发性有机化合物[VOC]，成分[PM2.5]）和肺功能（家用肺活量测定法）； 2a）评估住宅环境暴露的频率和程度（例如，消毒剂/清洁剂， 二手烟）通过（a）自我报告的数据，以及（b）家庭监控客观措施，2B）评估 自我报告的哮喘症状和肺功能表明的哮喘控制水平； 3）探索 自我报告和客观的住宅环境暴露与自我报告的关联 和哮喘控制的客观度量。我们将招募50名患有哮喘的成年人，他们完成了我们正在进行的 在线COVID-19和哮喘调查表明愿意与以后的研究联系，并报告很高 使用消毒剂/清洁产品，并具有无法控制的哮喘。参与者将获得室内 空气质量监测器和家用螺旋计分别测量VOC，PM2.5和FEV1％。 EMA会 使用个人智能手机和EMA软件平台收集。参与者将被安排发送，并且 随机评估哮喘症状，环境暴露，肺功能和缓解的通知 策略。在14天的数据收集期之后，参与者将回应与调查相关的项目 可接受性，适当性和可行性。这项可行性研究的发现将支持一项有能力的研究 解决与COVID-19有关的环境暴露的影响，并增强准备 未来的感染性疾病暴发，通过为哮喘患者制定创新的干预策略。