Identifying risk factors of Alzheimer's disease and related dementias in older Chinese immigrants

识别老年中国移民阿尔茨海默病和相关痴呆症的危险因素

• 批准号: 10448917
• 负责人: Clara Li
• 金额: $ 49.51万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10448917
• 关键词: Acculturation; Activities of Daily Living; Affect; Age; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Apolipoproteins; Area; Asia; Asian Americans; Assessment tool; Attention; Blood Vessels; Characteristics; Chinese; Chinese American; Chinese population; Cities; Cognition; Cognitive; Cohort Studies; Country; Data; Dementia; Development; Disease; Education; Elderly; Empirical Research; Evaluation; Fibrinogen; Gender; Genetic Risk; Goals; Health; Health Policy; Heterogeneity; Hispanic; Hispanic Populations; Immigrant; Immigration; Impaired cognition; Impairment; Individual; Intervention; Investigation; Language; Length of Stay; Life; Link; Literature; Measurement; Measures; Mediating; Mediator of activation protein; Medical; Memory; Mental Depression; New York City; Older Population; Outcome; Play; Policies; Population; Prevalence; Recording of previous events; Registries; Reporting; Research; Risk; Role; Screening procedure; Shapes; Subgroup; Testing; Work; bilingualism; clinical practice; cognitive change; cognitive function; cohort; demographics; design; disorder risk; disparity reduction; executive function; experience; follow-up; functional status; genetic risk factor; global health; health care disparity; high risk; modifiable risk; prevent; programs; psychologic; racial and ethnic disparities; recruit; risk variant; sex

Project Summary Chinese immigrant population has been increasing for the last few decades. Despite their increasing numbers, very little is known about the health of Chinese immigrants. As the immigrant population becomes older, there is a pressing need to understand their cognitive health and risk of developing Alzheimer’s Disease and Related disorder (AD/ADRD), a common health problem in older individuals. AD/ADRD is a loss of cognitive function – ability to think, remember, or reason – to such an extent that it interferes with an individual’s day-to-day life and activities. Among all the study on immigration and cognition, only a few of them was focused specifically on Chinese immigrants. To date, existing findings on the linkages of immigration and cognition are mixed. Some studies reported worse cognitive function in immigrants than the US-born, whereas others found better cognitive function or no difference. In terms of measurement, immigration measures were limited to country born, age at immigration, and length of stay. Very little attention has been given to the influence of pre-immigration (e.g., reasons for immigration and early-life conditions) and post-immigration experiences (e.g., acculturation) on cognitive changes. In addition, cognitive function was largely defined by global cognition. Little is known regarding the effect of immigration on changes in specific cognitive domains, including areas of memory, executive function, and language (known as early cognitive markers of AD/ADRD). Previous studies have reported clusters of factors which explain the relationship between immigration and cognition, including: age, gender, education, depression, vascular health, and genetic risk factors. New York City has by far the highest Chines population of any city outside Asia. The Alzheimer’s Disease Research Center (ADRC) at Mount Sinai, located in New York City, has a successful record of engaging and evaluating Chinese American older adults, with an existing cohort of over 200 older Chinese immigrants who were fully characterized according to demographic variables, medical illnesses, psychological conditions, functional status, and genetic risks following a standard dementia evaluation. The purpose of this study is to expand the dementia evaluation to include measures of pre- and post-immigration experiences. We aim to: (1) elucidate the associations between immigration and cognition using comprehensive measures of immigration history along with a cognitive re- evaluation; and (2) identify potential mediators and moderators influencing such associations by leveraging the fullness of the baseline data. 100 well-characterized older Chinese immigrants will be recruited from the ADRC at Mount Sinai for the proposed study. This study will provide preliminary data for a larger study to examine the associations between immigration and cognition among older Chinese immigrants. Understanding mechanisms through which immigration experiences influence cognitive outcomes among the immigrant population will guide the development of tailored interventions to prevent AD/ADRD.

项目概要 过去几十年来，中国移民人口一直在增加，尽管数量不断增加。 随着移民人口老龄化，人们对中国移民的健康状况知之甚少。 迫切需要了解他们的认知健康状况和患阿尔茨海默病及相关疾病的风险 AD/ADRD 是老年人常见的健康问题，是认知功能丧失。 思考、记忆或推理的能力——以至于干扰个人的日常生活和 在所有关于移民和认知的研究中，只有少数活动专门针对移民和认知。 迄今为止，关于移民与认知之间联系的现有研究结果是复杂的。 研究报告称，移民的认知功能比美国出生的人更差，而其他研究则发现移民的认知功能更好 在衡量方面，移民措施仅限于出生国家、年龄。 很少有人关注移民前的影响（例如， 移民的原因和早期生活状况）以及移民后的经历（例如文化适应） 此外，认知功能很大程度上是由整体认知来定义的。 关于移民对特定认知领域（包括记忆领域）变化的影响， 执行功能和语言（被称为 AD/ADRD 的早期认知标志）。 报告了解释移民与认知之间关系的一系列因素，包括：年龄、 性别、教育、抑郁、血管健康和遗传风险因素是纽约市迄今为止最高的。 亚洲以外任何城市的华人人口。 西奈山阿尔茨海默病研究中心 (ADRC) 位于纽约市，在吸引和评估华裔美国老年人方面拥有成功的记录， 现有 200 多名老年中国移民群体，他们的特征完全符合 人口统计学变量、医疗疾病、心理状况、功能状态和遗传风险 标准痴呆症评估 本研究的目的是扩大痴呆症评估范围。 我们的目标是：（1）阐明移民前后经历之间的关联。 移民和认知使用移民历史的综合测量以及认知重新评估 (2) 通过利用 ADRC 将从基线数据中招募 100 名特征良好的老年中国移民。 在西奈山进行拟议的研究，这项研究将为更大规模的研究提供初步数据，以检验该研究。 移民与中国老年移民认知机制之间的关联。 移民经历影响移民人口的认知结果将指导 制定针对性的干预措施来预防 AD/ADRD。