Identifying risk factors of Alzheimer's disease and related dementias in older Chinese immigrants

识别老年中国移民阿尔茨海默病和相关痴呆症的危险因素

• 批准号: 10448917
• 负责人: Clara Li
• 金额: $ 49.51万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10448917
• 关键词: Acculturation; Activities of Daily Living; Affect; Age; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Apolipoproteins; Area; Asia; Asian Americans; Assessment tool; Attention; Blood Vessels; Characteristics; Chinese; Chinese American; Chinese population; Cities; Cognition; Cognitive; Cohort Studies; Country; Data; Dementia; Development; Disease; Education; Elderly; Empirical Research; Evaluation; Fibrinogen; Gender; Genetic Risk; Goals; Health; Health Policy; Heterogeneity; Hispanic; Hispanic Populations; Immigrant; Immigration; Impaired cognition; Impairment; Individual; Intervention; Investigation; Language; Length of Stay; Life; Link; Literature; Measurement; Measures; Mediating; Mediator of activation protein; Medical; Memory; Mental Depression; New York City; Older Population; Outcome; Play; Policies; Population; Prevalence; Recording of previous events; Registries; Reporting; Research; Risk; Role; Screening procedure; Shapes; Subgroup; Testing; Work; bilingualism; clinical practice; cognitive change; cognitive function; cohort; demographics; design; disorder risk; disparity reduction; executive function; experience; follow-up; functional status; genetic risk factor; global health; health care disparity; high risk; modifiable risk; prevent; programs; psychologic; racial and ethnic disparities; recruit; risk variant; sex

Project Summary Chinese immigrant population has been increasing for the last few decades. Despite their increasing numbers, very little is known about the health of Chinese immigrants. As the immigrant population becomes older, there is a pressing need to understand their cognitive health and risk of developing Alzheimer’s Disease and Related disorder (AD/ADRD), a common health problem in older individuals. AD/ADRD is a loss of cognitive function – ability to think, remember, or reason – to such an extent that it interferes with an individual’s day-to-day life and activities. Among all the study on immigration and cognition, only a few of them was focused specifically on Chinese immigrants. To date, existing findings on the linkages of immigration and cognition are mixed. Some studies reported worse cognitive function in immigrants than the US-born, whereas others found better cognitive function or no difference. In terms of measurement, immigration measures were limited to country born, age at immigration, and length of stay. Very little attention has been given to the influence of pre-immigration (e.g., reasons for immigration and early-life conditions) and post-immigration experiences (e.g., acculturation) on cognitive changes. In addition, cognitive function was largely defined by global cognition. Little is known regarding the effect of immigration on changes in specific cognitive domains, including areas of memory, executive function, and language (known as early cognitive markers of AD/ADRD). Previous studies have reported clusters of factors which explain the relationship between immigration and cognition, including: age, gender, education, depression, vascular health, and genetic risk factors. New York City has by far the highest Chines population of any city outside Asia. The Alzheimer’s Disease Research Center (ADRC) at Mount Sinai, located in New York City, has a successful record of engaging and evaluating Chinese American older adults, with an existing cohort of over 200 older Chinese immigrants who were fully characterized according to demographic variables, medical illnesses, psychological conditions, functional status, and genetic risks following a standard dementia evaluation. The purpose of this study is to expand the dementia evaluation to include measures of pre- and post-immigration experiences. We aim to: (1) elucidate the associations between immigration and cognition using comprehensive measures of immigration history along with a cognitive re- evaluation; and (2) identify potential mediators and moderators influencing such associations by leveraging the fullness of the baseline data. 100 well-characterized older Chinese immigrants will be recruited from the ADRC at Mount Sinai for the proposed study. This study will provide preliminary data for a larger study to examine the associations between immigration and cognition among older Chinese immigrants. Understanding mechanisms through which immigration experiences influence cognitive outcomes among the immigrant population will guide the development of tailored interventions to prevent AD/ADRD.

项目摘要 在过去的几十年中，中国移民人口一直在增加。尽管数量越来越 关于中国移民的健康知之甚少。随着移民人口的年龄越大， 迫切需要了解他们的认知健康和发展阿尔茨海默氏病及相关的风险 疾病（AD/ADRD），这是老年人的常见健康问题。 AD/ADRD是认知功能的丧失 - 能够思考，记住或理性的能力 - 在一定程度上会干扰个人的日常生活和 活动。在所有关于移民和认知研究的研究中，只有少数专门针对 中国移民。迄今为止，关于移民和认知联系的现有发现是混合的。一些 研究报道，移民的认知功能比美国出生的差，而其他人则发现认知能力更好 功能或无差异。在测量方面，移民措施仅限于国家出生，年龄 移民和住院时间。很少关注移民前的影响（例如， 移民和早期状况的原因）和移民后经历（例如，适应） 认知变化。此外，认知功能在很大程度上由全球认知定义。鲜为人知 关于移民对特定认知领域变化的影响，包括记忆领域， 执行功能和语言（称为AD/ADRD的早期认知标记）。先前的研究已有 报道了一系列因素集群，这些因素解释了移民与认知之间的关系，包括：年龄， 性别，教育，抑郁，血管健康和遗传危险因素。纽约市的最高 亚洲以外任何城市的中国人口。西奈山的阿尔茨海默氏病研究中心（ADRC）， 位于纽约市，成功地记录和评估了美国的美国老年人， 现有的有200多名中国移民的现有队列，他们根据 人口统计学变量，医学疾病，心理状况，功能状况和遗传风险之后 标准痴呆评估。这项研究的目的是扩大痴呆症评估以包括 移民前后经历的度量。我们的目标是：（1）阐明 使用全面的移民历史衡量的移民和认知以及认知的重新认知 评估; （2）确定潜在的介体和主持人通过利用 基线数据的饱满度。将从ADRC招募100名特征良好的中国移民 在西奈山进行拟议的研究。这项研究将为大型研究提供初步数据，以检查 中国老年移民的移民与认知之间的关联。了解机制 移民经历会影响移民人口中的认知结果 开发量身定制的干预措施，以防止AD/ADRD。