Longitudinal Measurement of the Changing Sleep Need in Adolescence

青春期睡眠需求变化的纵向测量

• 批准号: 9595010
• 负责人: IRWIN FEINBERG
• 金额: $ 62.27万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9595010
• 关键词: 16 year old; Academy; Address; Adolescence; Adolescent; Adult; Age; American; Back; Basic Science; Beds; Brain; Child; Childhood; Cognition; Cognitive; Complex; Consensus; Data; Decision Making; Development; Dose; Drowsiness; Electroencephalography; Enrollment; Event; Frequencies; Goals; Habits; Health behavior; Human; Impaired health; Impairment; Investigation; Knowledge; Life; Light; Longitudinal Studies; Measurement; Measures; Medicine; Memory; Mental Health; Methods; National Heart, Lung, and Blood Institute; Neurosciences; Participant; Pattern; Performance; Problem behavior; Property; Public Health; Recommendation; Research; Scanning; Short-Term Memory; Sleep; Sleep Disorders; Teenagers; Testing; Time; Ursidae Family; adequate sleep; age effect; age related; base; cognitive function; cognitive testing; cohort; density; early adolescence; emerging adult; evidence base; evidence based guidelines; improved; indexing; interest; neurophysiology; novel; performance tests; physical conditioning; prospective; response; vigilance; young adult

Project Summary/Abstract The long-term goals of our research are to describe the age trajectories of sleep, sleep EEG, and sleep need, focusing on changes across and through adolescence. Achieving these goals will help fill major gaps in our knowledge, gaps which have direct and important implications for both public health and developmental neuroscience. Insufficient sleep and daytime sleepiness are associated with impaired physical and mental health and behavioral problems. Insufficient sleep is particularly critical during adolescence because of the profound reorganization of the human brain that takes place over the second decade of life. Despite its importance, we lack basic evidence on the quantitative relations of adolescent sleep durations to daytime sleepiness and performance. The recently released American Academy of Sleep Medicine consensus statement on adolescent sleep need was necessarily based mainly on post-hoc studies that showed correlations between poor sleep habits and impaired health and performance. Our proposed project will extend our ongoing prospective dose-response studies of the effects of varied sleep durations on daytime cognitive function, daytime sleepiness and sleep EEG patterns. The first 3 years of this study (spanning ages 10-16 years) revealed a number of interesting findings, including a divergence in the age effects of sleep duration on daytime sleepiness and daytime performance. The Continuing Renewal will extend our studies from mid-adolescence through young adulthood and allow us to determine whether the changes we observed thus far are transient maturational events or continue into adulthood. In addition to expanding the age range, the proposed continuation adds new measures and new methods of analysis of the effects of sleep duration effects on cognition. With the new additional data, the expanded study will span ages 10 to 23 years. By including the transition to young adulthood we can test rigorously the important basic science question of whether the adolescent changes in sleep duration-daytime sleepiness and performance relations are correlated with the steep adolescent decline of delta power in the NREM EEG; this decline is the most massive brain change of adolescence that can be measured non-invasively. The proposed studies will provide the first systematic longitudinal dose-response data on sleep need across this age range. Such data will begin to address the urgent need for evidence-based public health recommendations for adolescent sleep durations. Understanding the basic causes of daytime sleepiness in adolescence is a major goal of the National Center on Sleep Disorders Research of the National Heart Lung Blood Institute. The proposed studies will advance that understanding by providing the first longitudinal description of changes in sleep EEG and sleep need from late childhood through adolescence and into young adulthood. These data will also bear on the neuroscience of adolescent brain maturation.

项目摘要/摘要 我们研究的长期目标是描述睡眠，睡眠脑电图和睡眠需求的年龄轨迹， 专注于整个青春期的变化。实现这些目标将有助于填补我们的主要空白 知识，对公共卫生和发展具有直接和重要意义的差距 神经科学。睡眠不足和白天嗜睡与身体和精神障碍有关 健康和行为问题。由于 人类大脑的深刻重组发生在生命的第二个十年中。尽管有它 重要的是，我们缺乏有关青少年睡眠时间与白天的定量关系的基本证据 嗜睡和表现。最近发布的美国睡眠医学学院共识 关于青少年睡眠需求的陈述必然基于事后研究，该研究表明 睡眠不良习惯与健康和表现受损之间的相关性。我们提议的项目将 扩展我们正在进行的对白天睡眠持续时间影响的前瞻性剂量反应研究 认知功能，白天嗜睡和睡眠脑电图模式。这项研究的前三年（跨年龄 10-16岁）揭示了许多有趣的发现，包括睡眠年龄影响的差异 白天嗜睡和白天表现的持续时间。持续的更新将扩大我们的研究 从青春期中期到成年，让我们能够确定是否观察到的变化是否 到目前为止，是短暂的成熟事件或继续成年。除了扩大年龄范围外， 拟议的延续添加了新的措施和新的分析方法，对睡眠持续时间的影响 对认知的影响。有了新的附加数据，扩展的研究将跨越10至23岁。经过 包括过渡到年轻成年，我们可以严格测试重要的基础科学问题 青少年睡眠时间的嗜睡和表现关系的变化是否 与NREM EEG中三角洲力量的陡峭青春期相关；这种下降是最大的 青春期的大脑变化，可以无创测量。拟议的研究将提供第一个 在这个年龄范围内，有关睡眠需求的系统纵向剂量反应数据。这样的数据将开始 解决青少年睡眠时间基于证据的公共卫生建议的迫切需求。 了解青春期白天嗜睡的基本原因是国家中心的主要目标 关于国家心脏肺血液研究所的睡眠障碍研究。拟议的研究将进步 通过提供对睡眠脑电图变化和睡眠需求的首次纵向描述来理解 童年晚期至青春期到成年。这些数据也将依靠神经科学 青春期大脑成熟。