Syphilis in Chicago: Epidemiology, Sexual Networking and Modeling for Prevention

芝加哥梅毒：流行病学、性网络和预防模型

• 批准号: 9392441
• 负责人: RICHARD M NOVAK
• 金额: $ 59.14万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-05-01 至 2020-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9392441
• 关键词: Syphilis; Chicago; Epidemiology; Sexual; Networking

Project Title: Syphilis in Chicago: Epidemiology, Sexual Networking and Modeling for Prevention ABSTRACT The incidence of syphilis has been increasing in the US for at least 10 years, especially among men who have sex with men (MSM). Syphilis seroprevalence is higher among HIV-infected MSM, an indicator of condomless sexual contact and associated with incident HIV infection. Chicago is one of the major epicenters of the syphilis epidemic and includes the largest contiguous African American population in the United States. We propose to identify and characterize those at greatest risk for incident new and recurrent syphilis infections and better define the patterns of transmission, reinfection and co-infection within the social and sexual networks of a diverse group of MSM (16-39 years of age) who are disproportionately impacted. The study, STI Chicago Epidemiology Network Study (SCENES), will enroll 150 high-risk MSM using a recently developed two-step (2S) network recruitment approach in three of Chicago's highest prevalence neighborhoods and monitor them quarterly for 2 years for incident syphilis and other STIs including HIV. We will collect detailed social and sexual network, and risk behavior data and create a syphilis transmission model that is built upon our existing MSM agent-based HIV transmission model platform to incorporate detailed sexual network dynamics, syphilis treatment and reinfection. We will also work closely with our existing Chicago Department of Public Health programs and outreach clinics in order to coordinate treatment of STIs, determine previous treatment and infection histories, engage clients in care and provision of condoms and PrEP as is our current practice. This proposal will contribute valuable new knowledge about syphilis incidence in the highest prevalence neighborhoods in Chicago, and provide a clear understanding of syphilis mono- and co-infection networks. Sexual network analysis using dynamic exponential random graph models that are embedded within our existing agent-based model platform will provide an opportunity to include future genetic network data and serve as a framework for testing emerging prevention interventions prior to conducting clinical trials or implementing prevention strategies.

项目名称：芝加哥梅毒：流行病学、性网络和模型 预防 抽象的 至少 10 年来，美国梅毒的发病率一直在上升，尤其是 男男性行为者 (MSM)。梅毒血清流行率较高 感染 HIV 的 MSM，是无套性接触的一个指标，与 艾滋病毒感染事件。芝加哥是梅毒流行的主要震中之一 并包括美国最大的连续非裔美国人人口。 我们建议识别和描述那些面临新事件和事件风险最大的人 复发性梅毒感染并更好地确定传播、再感染的模式 以及在不同的 MSM 群体的社交和性网络中共同感染 (16-39 岁），他们受到的影响尤为严重。该研究，STI 芝加哥 流行病学网络研究 (SCENES) 将使用最近的一项研究招募 150 名高风险 MSM 在芝加哥三个最高的大学中开发了两步（2S）网络招聘方法 流行社区并在 2 年内每季度监测一次梅毒事件 和其他性传播感染，包括艾滋病毒。我们将收集详细的社交和性网络，以及风险 行为数据并创建一个基于我们现有的梅毒传播模型 基于 MSM 代理的 HIV 传播模型平台包含详细的性行为 网络动态、梅毒治疗和再感染。我们也将与我们的密切合作 现有的芝加哥公共卫生部计划和外展诊所，以便 协调性传播感染的治疗，确定既往治疗和感染史， 正如我们目前的做法，让客户参与护理并提供安全套和 PrEP。 该提案将贡献有关梅毒发病率的宝贵新知识 芝加哥流行率最高的社区，并提供清晰的了解 梅毒单一和混合感染网络。使用动态性网络分析 嵌入在我们现有的基于代理的指数随机图模型 模型平台将提供包含未来遗传网络数据和 作为在实施之前测试新兴预防干预措施的框架 临床试验或实施预防策略。