Pilot Project Component

试点项目组成部分

• 批准号: 9323203
• 负责人: Terrence Deak
• 金额: $ 12.69万
• 依托单位: STATE UNIVERSITY OF NY,BINGHAMTON
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9323203
• 关键词: Adolescent; Adult; Alcohols; Area; Award; Caring; Charge; Collaborations; Coping Behavior; DNA Methylation; Data; Development; Direct Costs; Dose; Effectiveness; Eligibility Determination; Epigenetic Process; Ethanol; Funding; Funding Mechanisms; Future; GABA-A Receptor; Goals; Growth; Health; Incubators; Life; Mentors; Mission; Modeling; Monitor; Mothers; National Institute of Drug Abuse; National Institute on Alcohol Abuse and Alcoholism; Neonatal; Outcome; Pilot Projects; Process; Publishing; Rattus; Recruitment Activity; Reporting; Research; Research Assistant; Research Personnel; Resources; Science; Scientist; Seasons; Seeds; Speed; Structure; Swimming; Talents; Testing; Time; United States National Institutes of Health; Work; adolescent alcohol exposure; alcohol exposure; alcohol research; alcohol sensitivity; base; career; career development; coping; experience; innovation; interest; member; novel; offspring; peer; professor; programs; pup; synergism; tenure track

The overarching goals of the Pilot Project Core are to (i) provide a structured funding mechanism to seed the development of great new ideas relevant to central themes of the DEARC; (ii) support career growth for both young and seasoned investigators through mentoring and facilitated collaboration; and (iii) capitalize on unique and timely opportunities that may arise from the rapidly changing, dynamic field of research on alcohol and development. The Pilot Project Core will achieve these goals through administration of a Pilot Project program that solicits Pilot Project Proposals from eligible investigators, coordinates the review process for proposals received, and ultimately oversees the award and reporting functions for all Pilot Projects. In addition, the Pilot Project Core, in close coordination with the Executive Committee, will help promote scientific connections among new members of the DEARC, and between these new members and established DEARC investigators to further increase scientific synergy and promote both peer-based and mentor-mentee relationships within the Center. Pilot Projects will be for 2 years each and funded at $30k (direct costs) each year. Using this approach, we will have a total of 6 funded pilot projects during the proposed 5-year funding period. Two highly innovative Pilot Project Proposals are proposed to begin in FY1. Pilot Project 1 (Cameron, PI) will examine the impact of maternal care during the neonatal period on DNA methylation and GABA-A receptor subunit expression, and how maternal care influences ethanol sensitivity later in life. Pilot Project 2 (Doremus-Fitzwater, PI) will examine the effect of adolescent ethanol exposure on coping behavior during aversive test situations, hypothesizing that adolescent ethanol exposure may differentially impact active versus passive coping strategies relative to adults. Through support of exciting new projects and promising investigators, the Pilot Project Core will serve as an incubator of great new ideas related to the central themes and mission of the DEARC.

试点项目核心的总体目标是（i）提供一种结构化的资金机制，以播种与Dearc的中心主题相关的伟大新思想的发展； （ii）通过指导和促进合作来支持年轻和经验丰富的调查人员的职业发展； （iii）利用迅速变化，动态的酒精和开发研究领域可能带来的独特和及时的机会。飞行员项目核心将通过管理试点项目计划实现这些目标，该计划计划从合格的调查人员那里征求试点项目建议，协调收到的建议的审查过程，并最终监督所有试点项目的奖励和报告职能。此外，试点项目核心与执行委员会密切协调，将有助于促进Dearc的新成员之间的科学联系，以及这些新成员与已建立的Dearc研究人员之间的科学联系，以进一步提高科学协同作用，并在中心内促进基于同伴的和导师的关系。试点项目将分别为2年，每年以3万美元（直接费用）提供资金。使用这种方法，我们将在拟议的5年资金期间共有6个资助的试点项目。提出了两个高度创新的试点项目建议，将在FY1中开始。 Pilot Project 1（Cameron，PI）将检查新生儿期间母体护理对DNA甲基化和GABA-A受体亚基表达的影响，以及母体护理如何影响以后生活中的乙醇敏感性。试点项目2（Doremus-Fitzwater，PI）将检查青少年乙醇暴露对厌恶测试情况下应对行为的影响，假设青少年乙醇暴露可能会差异地影响相对于成年人的活性和被动应对策略。通过支持激动人心的新项目和有前途的调查人员，试点项目核心将成为与Dearc的中心主题和使命有关的伟大新想法的孵化器。