Western States Node of the National Drug Abuse Treatment Clinical Trials Network

国家药物滥用治疗临床试验网络西部各州节点

基本信息

批准号：
9275472
负责人：
DENNIS MCCARTY
金额：
$ 70.22万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-09-30 至 2020-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9275472
关键词：
AIDS/HIV problem Address Alcohol consumption Amalgam American Indians Area Arizona Asian Americans Award California Caring Cities Clinic Clinical Clinical Data Clinical Treatment Clinical Trials Clinical Trials Network Collaborations Colorado Communities Conduct Clinical Trials Country County Data Disease Drug Use Disorder Drug abuse Education Electronic Health Record Evidence based practice Evidence based treatment Faculty Grant HIV HIV vaccine Hawaii Health Health Care Costs Health Personnel Health Sciences Healthcare Healthcare Systems Hepatitis C Information Networks Intervention Knowledge Leadership Link Los Angeles Measures Medical Mental Health Methadone Methods Naloxone National Institute of Drug Abuse Native Americans Opioid Oregon Overdose Pacific Island Americans Participant Patients Peer Review Persons Primary Health Care Progress Reports Protocols documentation Provider Public Health Publications Quality of Care Recruitment Activity Registries Reporting Research Research Personnel Research Training Resources Rivers Rural Rural Health Safety San Francisco Services Signal Transduction Site Social Workers Substance Use Disorder Talents Testing Time Training Translating Universities addiction base behavioral clinical trial behavioral health behavioral pharmacology brief alcohol intervention care delivery cost data resource design dissemination research drug abuse prevention evidence base experience health disparity health service use implementation research implementation science improved leadership development member patient population patient registry practice-based research network programs protocol development public health relevance rural Americans safety net therapeutic candidate treatment center treatment program urban Native American

项目摘要

DESCRIPTION: The Western States (WS) Node of the National Drug Abuse Treatment Clinical Trials Network (CTN) promotes evidence-based drug abuse prevention and treatment services through continued participation in the CTN. The Node 1) designs and implements clinical trials of evidence-based treatments of addiction through rapid recruitment of diverse study participants in partnership with NIDA and the CTN, 2) generates peer-reviewed publications in collaboration with treatment providers and other nodes, and 3) uses the CTN as a platform for training, dissemination, and research applications. The Regional Research and Training Center includes talented faculty and staff from Oregon Health & Science Center and University of California, San Francisco as well as leaders of affiliated healthcare partners providing integrated primary care and substance use disorder treatment. The Node was created in 2010 as an amalgam of two CTN Nodes--California-Arizona and Oregon/Hawaii (a charter member of the CTN). The Node was highly successful, during the current award, participating in 10 CTN trials, co-leading two of these and leading one; reporting results of CTN main studies, ancillary, and research using the CTN platform in 100+ publications, and actively disseminating evidence- based practices in 200 presentations. Node investigators also sought and received awards for 10 studies that used the CTN as a platform for research. Eight WS Node healthcare programs recruited over 1,300 participants into CTN studies. In the coming grant period the Node expands to include three national and regional primary care and HIV primary care research networks: OCHIN, the HIV Research Network, and the Oregon Rural Practice-Based Research Network (ORPRN). The Node retains core addiction treatment centers experienced in CTN protocols and exploits their links with primary care: Adapt (Roseburg, OR), CODA (Portland, OR) HealthRIGHT 360 (San Francisco, CA), La Frontera (Tucson, AZ), NARA (Portland, OR), and Signal Behavioral Health Network (Denver, CO). The Node's research agenda proposes study concepts that evaluate three strategies to integrate and enhance addiction treatment within healthcare settings. Study 1 builds a patient registry for HCV infection and tests a multi-contact brief intervention for alcohol use. Study 2 extends the registry testing a candidate therapeutic HIV vaccine. Study 3, a test of reverse integration (primary care clinicians in addiction treatment settings), assesses naloxone distribution and education to reduce fatal and nonfatal opioid overdoses and measures impact on return to use. Finally the WS Node continues to use the CTN as a platform for training, dissemination, and research applications. The Node has the potential to accelerate the advancement of integrated primary care and addiction in the coming years.

描述：国家药物滥用治疗临床试验网络（CTN）的西方国家（WS）节点通过继续参与CTN来促进基于证据的药物滥用和治疗服务。节点1）通过与NIDA和CTN合作的快速招募潜水员研究参与者的临床试验来设计和实施基于证据的成瘾治疗方法，2）与治疗提供者和其他节点合作生成经过PEER评论的出版物，以及3）使用CTN作为培训，培训，分发和研究应用程序的平台。区域研究与培训中心包括俄勒冈州健康与科学中心以及加利福尼亚大学，旧金山大学的才华横溢的教职员工以及会员医疗合作伙伴的领导人初级保健和药物使用障碍治疗。该节点于2010年创建为两个CTN节点的汞合金 - 加利福尼亚 - 阿里佐纳和俄勒冈州/夏威夷（CTN的特许成员）。该节点在当前奖项期间非常成功，参加了10次CTN试验，共同领先其中两个，并领导一个。在100多个出版物中使用CTN平台的CTN主要研究，辅助和研究的报告结果，并在200个演讲中积极传播基于证据的实践。节点研究人员还感知并获得了10项研究的奖项，该研究将CTN用作研究平台。八个WS节点医疗计划招募了1300多名参与者参加CTN研究。在未来的赠款期间，节点扩展到包括三个国家和地区初级保健和HIV初级保健研究网络：Ochin，HIV研究网络和俄勒冈州农村实践研究网络（ORPRN）。该节点保留在CTN方案中经历的核心加法中心，并利用其与初级保健的联系：Adapt（Roseburg，OR），Coda（Portland，OR）HealthRight 360（加利福尼亚州旧金山），La Frontera（Tucson，AZ，AZ），Nara（Portland，OR）和信号行为健康网络（Denver，Co）。该节点的研究议程提出了研究概念，该概念评估了三种在医疗机构中整合和增强治疗的策略。研究1为HCV感染建立了患者注册表，并测试了用于饮酒的多连接简短干预。研究2扩展了注册表测试候选治疗性HIV疫苗。研究3，反向整合的测试（成瘾治疗中的初级保健临床医生）。设置），评估纳洛酮的分布和教育，以减少致命和非致命的阿片类药物过量，并措施影响对使用的回报。最后，WS节点继续使用CTN作为培训，传播和研究应用的平台。该节点有可能在未来几年加速基础医疗和成瘾的进步。