Restoring oscillations underlying adaptive control in schizophrenia with direct current

用直流电恢复精神分裂症自适应控制的振荡

基本信息

批准号：
9344699
负责人：
SOHEE PARK
金额：
$ 39.23万
依托单位：
VANDERBILT UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-07 至 2021-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9344699
关键词：
Adaptive Behaviors Affect Anodes Area Attention Behavior Behavioral Brain Brain Diseases Brain region Cognitive Cognitive deficits Conflict (Psychology)Coupled Data Disease Electric Stimulation Electrical Stimulation of the Brain Electroencephalogram Exhibits Failure Feedback Frequencies Functional disorder Goals Gold Habits Hallucinations Health Care Costs Impaired cognition Impairment Individual Intervention Lead Link Measurement Measures Medial Methods Modeling Neurons Neurosciences Occupational Occupations Outcome Patients Pattern Pharmaceutical Preparations Phase Population Process Protocols documentation Public Health Research Schizophrenia Sensory Signal Transduction Stimulus System Techniques Time Translating United States Work behavior measurement cognitive ability cognitive control cognitive function cognitive process cost disability flexibility frontal lobe improved insight prevent programs psychotic symptoms response restoration social success tool

项目摘要

PROJECT SUMMARY Schizophrenia is a severe and debilitating disorder that affects about 51 billion people worldwide, and costs more than $60 billion annually in United States (Salomon and al., 2013). Despite the more spectacular psychotic symptoms of schizophrenia (e.g., hallucinations), it is the cognitive impairments that largely drive the poor outcomes from the illness, such as preventing patients from keeping jobs, due to the inability of medications to effectively treat these cognitive impairments (Gold and Weinberger, 1995; Green, 1996; Elvevag and Goldberg, 2000). Failures of adaptive control are a hallmark of the cognitive impairments in schizophrenia. Adaptive control allows healthy individuals to follow rules and to override compelling competing responses. Impairments of adaptive control result in errors and an inability to change following negative feedback. In systems neuroscience, a growing body of evidence demonstrates that adaptive control processes are supported by oscillatory activity in the healthy brain (Luu et al., 2003; Wang et al., 2005; Cavanagh et al., 2009; van Driel et al., 2012; Anguera et al., 2013; Narayanan et al., 2013; Cavanagh and Frank, 2014), and that certain patterns of oscillatory dynamics might be useful for understanding the cognitive impairments in schizophrenia (Ford and Mathalon, 2008; Uhlhaas and Singer, 2010; Lesh et al., 2011). In this project, we propose to use a causal neuroscientific technique, noninvasive electrical brain stimulation, combined with measurements of electroencephalographic oscillations to determine whether modifying certain oscillatory rhythms in patients with schizophrenia can improve cognitive abilities. Our preliminary data are highly encouraging and indicate that we can selectively manipulate the phase of oscillatory activity and cause improvements in the adaptive control exhibited by patients with schizophrenia. The goals of our research are to use the tools and insights from basic neuroscience to gain a deeper understanding the cognitive impairments in schizophrenia, and achieve concrete translational progress toward a non-pharmacological therapy for boosting cognitive function in schizophrenia. 1

项目概要精神分裂症是一种严重的、使人衰弱的疾病，影响着全世界约 510 亿人，并且造成了巨大的经济损失美国每年超过 600 亿美元（Salomon 等人，2013 年）。精神分裂症的精神病症状（例如幻觉），认知障碍在很大程度上驱动了疾病造成的不良后果，例如由于患者无法保住工作而无法保住工作有效治疗这些认知障碍的药物（Gold 和 Weinberger，1995；Green，1996； Elvevag 和 Goldberg，2000）。适应性控制失败是认知障碍的标志。精神分裂症使健康的个体能够遵守规则并克服令人信服的竞争。适应性控制的受损会导致错误并且无法在负面反应后做出改变。在系统神经科学中，越来越多的证据表明自适应控制过程。受到健康大脑振荡活动的支持（Luu 等人，2003 年；Wang 等人，2005 年；Cavanagh 等人， 2009；van Driel 等，2012；Anguera 等，2013；Cavanagh 和 Frank，2014；振荡动力学的某些模式可能有助于理解认知障碍精神分裂症（Ford 和 Mathalon，2008 年；Uhlhaas 和 Singer，2010 年；Lesh 等人，2011 年）。建议使用因果神经科学技术，即无创性脑电刺激，并结合测量脑电图振荡以确定是否改变某些振荡我们的初步数据表明，精神分裂症患者的节律可以提高认知能力。鼓励并表明我们可以选择性地操纵振荡活动的阶段并导致我们研究的目标是改善精神分裂症患者的适应性控制表现。使用基础神经科学的工具和见解来更深入地了解认知障碍精神分裂症，并在非药物治疗方面取得具体转化进展增强精神分裂症的认知功能。 1