Terry Beirn CPCRA Clinical Trials Unit

Terry Beirn CPRA 临床试验单位

• 批准号: 9184539
• 负责人: Fred M Gordin
• 金额: $ 487.6万
• 依托单位: GEORGE WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-15 至 2020-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9184539
• 关键词: AIDS clinical trial group; Acquired Immunodeficiency Syndrome; Affect; African American; Behavioral; Clinical Research; Clinical Research Associate; Clinical Trials; Clinical Trials Network; Clinical Trials Unit; Collaborations; Communities; Comorbidity; Data; Development; Diagnosis; Enrollment; Ensure; Epidemic; Fostering; Funding; Geography; Goals; Grant; HIV; HIV Infections; Health; Hepatitis; Hospitals; Individual; Infection; Infection prevention; Infectious hepatitides; Institution; Latino; Leadership; Medical; Medical center; Medicine; Mentors; Minority Groups; Names; Participant; Patient Care; Patients; Persons; Population Heterogeneity; Prevalence; Prevention; Prevention Research; Prevention strategy; Principal Investigator; Protocols documentation; Public Health; Publications; Randomized Clinical Trials; Regimen; Research; Research Personnel; Risk; Scientist; Site; Structure; Subgroup; Target Populations; Therapeutic; Training; Translations; Tuberculosis; Universities; Veterans; Viral hepatitis; Virginia; Washington; Woman; Work; career development; clinical research site; clinically relevant; demographics; design; ethnic diversity; ethnic minority population; expectation; experience; high risk; improved; member; next generation; novel therapeutic intervention; pre-exposure prophylaxis; prevent; racial diversity; racial minority; seroconversion; socioeconomics; tuberculosis treatment; viral transmission; working group

DESCRIPTION (provided by applicant): The Terry Beirn CPCRA Clinical Trials Unit is composed of investigators and research staff at 7 Clinical Research Sites with over 20 years of experience in HIV, hepatitis, tuberculosis and prevention research and patient care and with an established record of effective and efficient collaboration over the past 6 years. The CPCRA CTU aims to conduct clinically relevant research in the prevention and treatment of HIV, hepatitis, and tuberculosis; to enroll a demographically, geographically, and socio-economically diverse population of individuals into clinical trials; and to carry out this research agenda in clse collaboration with community members who are themselves affected by HIV, hepatitis, or tuberculosis. The Terry Beirn CPCRA CTU will make significant contributions to the ACTG and HPTN leadership groups, both in enrollment and in scientific expertise. Through the ACTG, the CPCRA CTU will contribute to multiple, randomized clinical trials in strategies to cure and/or achieve functional cure of HIV, studies to improve the diagnosis and treatment of tuberculosis, strategies to cure infectious hepatitis, and strategies to improve the treatment of, or prevent, non-infectious co-morbidities and evaluate novel therapeutic interventions targeting HIV infection. Through the HPTN, the CPCRA CTU will evaluate and optimize integrated strategies to prevent HIV infection, and evaluate and optimize the most promising pre-exposure prophylaxis (PrEP) regimens. Targeted populations include those who are H1V+ as well as those who are HIV- and at-risk for seroconversion, especially high-risk subgroups. The Administrative Office of the CPCRA CTU located at the Veterans Affairs Medical Center in Washington, DC, is an off-campus affiliate of the applicant organization, the George Washington University. The CTU Principal Investigator and Administrative Office staff provide oversight, coordination, training, technical assistance and regulatory support for 7 Clinical Research Sites, 6 affiliated with the ACTG (Denver Public Health, Henry Ford Hospital, Houston AIDS Research Team, Virginia Commonwealth University, Wayne State University) and 1 with HPTN (George Washington University). RELEVANCE: Ongoing research on prevention and treatment of HIV, tuberculosis and hepatitis is imperative given the continued prevalence of these global infections. Investigators affiliated with the Terry Beirn CPCRA CTU and its 7 Clinical Research Sites are experienced, competent, and committed to make significant contributions to reduce the burden of these infections on people's lives.

描述（由申请人提供）：Terry Beirn CPCRA临床试验单元由7个临床研究地点的研究人员和研究人员组成，在过去6年中，在HIV，肝炎，结核病和预防研究和患者护理方面具有超过20年的艾滋病毒，肝炎，结核病和预防研究和患者护理的记录。 CPCRA CTU旨在在预防和治疗HIV，肝炎和结核病方面进行临床相关的研究。在人口统计学，地理和社会经济上的个人人群中注册临床试验；并在CLSE合作中与受艾滋病毒，肝炎或结核病影响的社区成员合作执行这项研究议程。特里·贝恩（Terry Beirn）CPCRA CTU将为ACTG和HPTN领导力小组做出重大贡献，包括入学率和科学专业知识。 Through the ACTG, the CPCRA CTU will contribute to multiple, randomized clinical trials in strategies to cure and/or achieve functional cure of HIV, studies to improve the diagnosis and treatment of tuberculosis, strategies to cure infectious hepatitis, and strategies to improve the treatment of, or prevent, non-infectious co-morbidities and evaluate novel therapeutic interventions targeting HIV infection.通过HPTN，CPCRA CTU将评估和优化综合策略，以防止HIV感染，并评估和优化最有希望的预防前预防（PREP）方案。有针对性的人群包括H1V+以及艾滋病毒和处于血清的艾滋病毒和高危亚组的人群。 CPCRA CTU的行政办公室位于华盛顿特区退伍军人事务医疗中心，是申请人组织乔治华盛顿大学的校外分支机构。 CTU首席调查员和行政办公室工作人员为7个临床研究地点提供监督，协调，培训，技术援助和监管支持，其中6名与ACTG（丹佛公共卫生，亨利·福特医院，休斯顿艾滋病医院，休斯顿艾滋病研究小组，弗吉尼亚州英国联邦大学，韦恩州立大学，韦恩州立大学）和1所（George Washington University）。 相关性：鉴于这些全球感染的持续患病率，对预防和治疗HIV，结核病和肝炎的持续研究至关重要。与Terry Beirn CPCRA CTU及其7个临床研究站点相关的研究人员经验丰富，有能力，并致力于做出重大贡献，以减轻这些感染对人们生活的负担。