Air Pollution and Autism in Israel: A Population-Wide Study

以色列的空气污染和自闭症：一项全人口研究

• 批准号: 9132918
• 负责人: Marc G Weisskopf
• 金额: $ 22.25万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-30 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9132918
• 关键词: Accounting; Address; Air Pollutants; Air Pollution; Autistic Disorder; Back; Biological Factors; Caliber; California; Characteristics; Child; Cohort Studies; Confounding Factors (Epidemiology); Data; Data Sources; Databases; Development; Dose; Dust; European; Event; Exposure to; Family; Family Characteristics; Fetus; Future; Genetic; Goals; Health; Hour; Incidence; Individual; Investigation; Israel; Link; Maternal Exposure; Modeling; Nitrogen Dioxide; Particulate Matter; Perinatal; Pollution; Population; Population Research; Pregnancy; Prevalence; Public Health; Regulation; Resolution; Rest; Risk; Risk Factors; Role; Siblings; Specificity; Staging; Sweden; Symptoms; Taiwan; Time; Tracer; Twin Multiple Birth; Variant; Vulnerable Populations; Work; abstracting; autism spectrum disorder; base; boys; cohort; evidence base; girls; improved; male; maternal stress; modifiable risk; offspring; pollutant; prenatal exposure; response; sex; traffic-related air pollution; trafficking

Project Summary/Abstract Several studies have explored associations of air pollution with autism spectrum disorders (ASD), with all but one suggesting that some aspect of air pollution increases the risk of ASD, but details of this association remain uncertain. While these studies have found associations with, in particular, traffic-related pollutants and particulate matter (PM), they have in general been relatively small and most have been limited to California. One study in Taiwan, one in Sweden (among twins), and one combining several European cohorts are the only non-U.S. studies, and they came to different conclusions. More exploration of these exposures are needed outside the U.S. context. Furthermore, understanding critical windows of exposure, and susceptible populations is critical. A study of ours and one other have suggested effects specific to the 3rd trimester. Prior work of ours has also suggested that associations with air pollutants may be specific to boys, but the numbers of ASD cases among girls were too small to adequately address this. Our goal is to examine the basic question of the association between maternal exposure to air pollutants and ASD, and details of any association, in a very large cohort in a very different setting: the population of Israel. Israel represents a unique setting for the study of air pollutants and ASD for several reasons: 1) Air pollution levels are higher and with a wider range than in the US; 2) Dust storms occur sporadically that create very well timed extreme exposure events to a very different form of PM; 3) we have well-validated, highly resolved—in both space and time—models of both PM and nitrogen dioxide (NO2, a marker of traffic-related air pollution) exposure; and 4) the database is very large with over 8,000 ASD cases across the entire Israeli population going back several years. With these data we will examine the association between maternal exposure to PM, NO2, and dust storms and risk of ASD in her child. We will have exposure estimates on a weekly time scale and can examine susceptible windows of exposure in the perinatal period, and whether any association is specific to boys or modified by other key factors, such as whether the family is simplex or multiplex, to an extent not previously done.

项目摘要/摘要 几项研究探讨了空气污染与自闭症谱系障碍（ASD）的关联，除 一个暗示空气污染的某些方面会增加ASD的风险，但该关联的细节 保持不确定。尽管这些研究发现与交通相关的污染物和 颗粒物（PM），它们通常相对较小，大多数都限于加利福尼亚。 台湾的一项研究，一项在瑞典（双胞胎中）的一项研究，其中一项结合了几个欧洲人群是唯一的 非美国研究，他们得出了不同的结论。需要更多地探索这些暴露 在美国背景之外。此外，了解曝光的关键窗户和易感性 人口至关重要。对我们和其他人的研究提出了针对第三个孕期的影响。事先的 我们的工作还表明，与空气污染物的关联可能针对男孩，但数字 女孩中的ASD病例太小了，无法充分解决这个问题。我们的目标是检查基本问题 孕产妇接触空气污染物和ASD之间的关联，以及任何关联的细节 在截然不同的环境中非常大的队列：以色列的人口。以色列代表了 空气污染物和ASD的研究有几个原因：1）空气污染水平较高，并且范围更大 比在美国； 2）零星发生沙尘暴，这会产生非常定时的极端暴露事件 PM的非常不同的形式； 3）我们有很好的验证，高度解决的（在空间和时间上）两者的模型 PM和二氧化氮（NO2，与交通相关的空气污染的标记）暴露； 4）数据库非常 整个以色列人口中有超过8,000例ASD案件可以追溯到几年。使用这些数据 我们将研究母校接触到PM，No2和Dist Storms和ASD风险之间的关联 她的孩子。我们将在每周的时间范围内进行暴露估算，并可以检查 在围产期的暴露期以及任何关联是特定于男孩还是由其他钥匙修改 因素是以前未完成的因素，例如家庭是单纯形还是多重。