A Prospective Study of Nicotine from Edible Solanaceae and Risk of Parkinson Disease

食用茄科植物中尼古丁与帕金森病风险的前瞻性研究

• 批准号: 9258504
• 负责人: Xiang Gao
• 金额: $ 7.86万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-15 至 2019-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9258504
• 关键词: Adverse effects; Affect; Age; American; Behavioral; Biological Markers; Botanicals; Brain; Caffeine; Capsicum; Caregivers; Case-Control Studies; Cigarette; Consumption; Coronary heart disease; Data; Development; Diet; Dietary intake; Disease; Disease Progression; Environmental Tobacco Smoke; Family; Fibrinogen; Follow-Up Studies; Food; Future; Genetic; Health Professional; Ibuprofen; Intake; Investigation; Juice; Life Style; Malignant neoplasm of lung; Neurodegenerative Disorders; Neuroprotective Agents; Nicotine; Nicotinic Receptors; Nurses' Health Study; Onset of illness; Parkinson Disease; Participant; Passive Smoking; Patient Self-Report; Patients; Potato; Prevention; Prospective Studies; Quality of life; Research Design; Retrospective Studies; Risk; Risk Factors; Safety; Sample Size; Sampling; Smoke; Smoker; Smoking; Smoking Behavior; Solanaceae; Source; Structure of nail of toe; Subgroup; Tobacco; Tomatoes; Translating; United States; Woman; aging population; alpha synuclein; base; cigarette smoking; clinical practice; cohort; disability; disorder prevention; disorder risk; environmental tobacco smoke exposure; epidemiology study; follow-up; lifestyle factors; men; never smoker; novel; prevent; prospective; protective effect; public health relevance; treatment strategy

 DESCRIPTION (provided by applicant): Parkinson disease (PD) is the second most common neurodegenerative disease in the United States and affects over one million Americans; this number is growing due to population aging. Most patients eventually develop severe disability, which markedly affects their quality of life and that of their caregivers. There is thus a compellig need to develop disease modifying or neuroprotective treatments. In previous epidemiologic studies, cigarette smoking has been consistently shown to be associated with a lower risk of PD in men and women. Based on these observations, nicotine has been proposed to be a potential neuro-protective agent. However, the association between smoking and lower PD risk could be explained by a still-unknown third factor that increases the risk of PD and also causes an aversion to smoking behavior. In this context, it is of importance to examine whether nicotine from other sources, rather than cigarettes, is also associated with altered PD risk. Because a small amount of nicotine can saturate a substantial portion of nicotine receptors in the brain, we thus are able to examine the potential effects of dietary nicotine consumption on PD risk. This would provide strong evidence arguing for or against the potential casual relationship between nicotine and altered PD risk and is also important for the development of a novel prevention/treatment strategy. We thus propose to conduct a large-scale prospective study to examine whether dietary intake of nicotine and nicotine-containing solanaceae is associated with PD risk in two ongoing US cohorts including over 78,000 men and women who had never smoked. During 26-32 years of follow-up, we documented 921 incident cases of PD since dietary data were collected. We propose to examine 1) whether greater consumptions of dietary nicotine and nicotine-containing solanaceae are associated with lower risk of developing PD and 2) whether the association between dietary nicotine is more pronounced among those without environmental tobacco smoke exposure. As a secondary aim, we will examine the association between dietary intake of nicotine and toenail nicotine level, a long-term biomarker of nicotine exposure among 1,217 HPFS/NHS never-smokers with both data available. Finally, we will explore possible interactions between dietary nicotine and genetic factors (i.e., CHRNA5, iNOS2a, and SNCA) among never-smokers which have been previously shown to modify the smoking-PD relationship. Of note, with over 900 incident PD case, this is the only large prospective investigation of PD risk factors that includes repeated and detailed assessments of diet and other lifestyle factors. Given nicotine from tobacco may have adverse effects, the disease-modifying potential of dietary nicotine is of great value. This result could easily be translated in clinical practices due to the safety, acceptableness, and wide availability of edible solanaceae foods.

 描述（由适用提供）：帕金森氏病（PD）是美国第二常见的神经退行性疾病，影响了100万美国人；由于人口衰老，这个数字正在增长。大多数患者最终会出现严重的残疾，这显着影响了他们的生活质量和护理人员的生活质量。因此，有必要发展改变疾病或神经保护治疗的疾病。在先前的流行病学研究中，始终证明吸烟与男性和女性的PD风险较低有关。基于这些观察结果，尼古丁被认为是一种潜在的神经保护剂。但是，吸烟与较低的PD风险之间的关联可以通过仍然不确定的第三个因素来解释，该因素增加了PD的风险，也会导致对吸烟行为的厌恶。在这种情况下，检查其他来源而不是香烟的尼古丁是否也与PD风险改变有关。由于少量尼古丁可以饱和大脑中的大部分尼古丁受体，因此我们能够检查饮食中尼古丁消耗对PD风险的潜在影响。这将提供有力的证据，以争取或反对尼古丁与PD风险改变的潜在随意关系，并且对于小说的发展也很重要。预防/治疗策略。因此，我们建议进行一项大规模的前瞻性研究，以检查尼古丁和含尼古丁的茄科的饮食摄入是否与正在进行的两项正在进行的美国同伙中的PD风险有关，包括78,000多名从未吸烟的男人和女性。在26 - 32年的随访中，我们记录了921例PD事件，因为收集了饮食数据。我们建议检查1）饮食中尼古丁和含尼古丁的茄科是否与较低的PD风险相关，以及2）在没有环境烟草烟雾烟雾的人群中，饮食中尼古丁之间的关联是否更明显。作为次要目的，我们将研究尼古丁饮食摄入和脚趾甲尼古丁水平之间的关联，这是1,217 hpfs/nhs从未吸烟的尼古丁暴露的长期生物标志物与两种可用数据。最后，我们将探索饮食中的尼古丁和遗传因素（即CHRNA5，INOS2A和SNCA）之间的可能相互作用，这些因素以前已被证明可以改变吸烟-PD的关系。值得注意的是，有900多个事件PD案例，这是PD风险因素的唯一大量前瞻性投资，其中包括对饮食和其他生活方式因素的重复评估和详细评估。鉴于烟草的尼古丁可能会产生不利影响，饮食尼古丁的疾病改良潜力具有很大的价值。由于安全性，可接受性和可食用的广泛可用性，因此可以轻松地在临床实践中翻译此结果 茄科食品。