Systems Biology of Morphogeneisis and Spatial Information Flow

形态发生和空间信息流的系统生物学

基本信息

批准号：
9116855
负责人：
Arthur D Lander
金额：
$ 231.06万
依托单位：
UNIVERSITY OF CALIFORNIA-IRVINE
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-08-01 至 2018-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9116855
关键词：
Aging Area Binding Biological Biological Process Biology California Cells Cellular biology Collaborations Communities Complex Computers Conceptions Congenital Abnormality DNA Data Development Developmental Biology Education Education and Outreach Educational workshop Embryo Engineering Environment Faculty Fluorescence Fostering Funding Gene Expression Grant Growth Homeostasis Image Image Analysis Interdisciplinary Study Interest Group International Joints Journals Laboratories Leadership Life Location Malignant Neoplasms Maps Mathematical Biology Mentors Methods Modeling Molecular Morphogenesis Motor National Institute of General Medical Sciences Natural regeneration Nature Optics Organ Organism Pathologic Processes Pattern Pattern Formation Phosphotransferases Positioning Attribute Postdoctoral Fellow Process Recruitment Activity Regulation Request for Proposals Research Research Personnel Research Project Grants Running Scientist Seeds Shapes Signal Transduction Spatial Design Specific qualifier value Structure Students Systems Biology Time Tissue Model Tissues Training Training Activity Training Programs Underrepresented Groups Universities Visit Work Wound Healing base biological systems college community building community college complex biological systems computerized tools design dynamic system experience high school insight meetings nanoimaging nanoscale novel outreach programs symposium tenure track tool transcription factor

项目摘要

Systems Biology seeks to explain the complexity of life by revealing the basic strategies used by organisms to carry out diverse, demanding tasks in an uncertain world. Many Systems Biological approaches focus on the dynamic nature of living systems, but cells, tissues, and organisms don't just vary in time, they vary in space. Patterns must be specified, shapes and sizes must be controlled, and transport of signals and cargoes from one location to another must be regulated. For the last 4-1/2 years, the Center for Complex Biological Systems at the University of California, Irvine has operated as a National Center for Systems Biology, with a focus on Spatial Dynamics, the study of spatial phenomena and spatial design principles in biology. Taking advantage of collective strength in modeling, imaging and experimental methods, teams of molecular and cellular biologists, mathematicians, computer scientists, physicists and engineers have worked together to tackle a variety of spatial problems, from the subcellular to the organ level. During the next five years, the center proposes to extend this work with new research in five theme areas: pattern formation; tissue growth control; spatial control of intracellular signaling; development of mathematical and computational tools; and developmental of optical tools for spatial dynamics and nano-imaging. In addition, the center will maintain and expand upon an array of educational and outreach activities developed during the current funding period, including graduate, undergraduate and high school training activities; a short course for professionals in Systems Biology; faculty recruiting; symposia, workshops, regional meetings, retreats, and activities aimed at promoting workforce diversity.

系统生物学试图通过揭示生物体在不确定的世界中执行多样化、艰巨的任务所使用的基本策略来解释生命的复杂性。许多系统生物学方法关注生命系统的动态本质，但细胞、组织和生物体不仅随时间变化，而且随空间变化。必须指定图案，必须控制形状和尺寸，并且必须规范信号和货物从一个地点到另一个地点的运输。在过去的 4-1/2 年里，加州大学欧文分校复杂生物系统中心作为国家系统生物学中心运作，重点关注空间动力学、空间现象和空间设计原理的研究。生物学。利用建模、成像和实验方法方面的集体力量，分子和细胞生物学家、数学家、计算机科学家、物理学家和工程师团队共同努力解决从亚细胞到器官水平的各种空间问题。在未来五年内，该中心建议在五个主题领域扩展这项工作，进行新的研究：模式形成；组织生长控制；细胞内信号传导的空间控制；数学和计算工具的开发；以及空间动力学和纳米成像光学工具的开发。此外，该中心将维持并扩展当前资助期间开展的一系列教育和外展活动，包括研究生、本科生和高中培训活动；系统生物学专业人士的短期课程；师资招聘；旨在促进劳动力多元化的专题讨论会、讲习班、区域会议、务虚会和活动。

项目成果

期刊论文数量（179）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Advanced fluorescence microscopy methods for the real-time study of transcription and chromatin dynamics.

DOI：
10.4161/trns.28425
发表时间：
2014
期刊：
Transcription
影响因子：
0
作者：
Annibale P;Gratton E
通讯作者：
Gratton E

Assessment of Membrane Fluidity Fluctuations during Cellular Development Reveals Time and Cell Type Specificity.

DOI：
10.1371/journal.pone.0158313
发表时间：
2016
期刊：
PloS one
影响因子：
3.7
作者：
Noutsi P;Gratton E;Chaieb S
通讯作者：
Chaieb S

Three-dimensional multispecies nonlinear tumor growth-II: Tumor invasion and angiogenesis.

DOI：
10.1016/j.jtbi.2010.02.036
发表时间：
2010-06-21
期刊：
JOURNAL OF THEORETICAL BIOLOGY
影响因子：
2
作者：
Frieboes, Hermann B.;Jin, Fang;Chuang, Yao-Li;Wise, Steven M.;Lowengrub, John S.;Cristini, Vittorio
通讯作者：
Cristini, Vittorio

A BMP-FGF morphogen toggle switch drives the ultrasensitive expression of multiple genes in the developing forebrain.