MicroPET-MR scanner for preclinical molecular imaging

用于临床前分子成像的 MicroPET-MR 扫描仪

• 批准号: 8639739
• 负责人: Umar Mahmood
• 金额: $ 59.9万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-15 至 2016-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8639739
• 关键词: Algorithms; Anatomy; Animals; Area; Back; Boston; Brain; Chemistry; Communities; Complement; Data Collection; Development; Devices; Discipline; Discipline of Nuclear Medicine; Disease; Ensure; Evaluation; Funding; Funding Agency; General Hospitals; Genetically Engineered Mouse; Human; Image; Kinetics; Magnetic Resonance; Magnetic Resonance Imaging; Magnetism; Massachusetts; Measures; Modality; Modeling; Molecular; Multimodal Imaging; Mus; National Heart, Lung, and Blood Institute; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Biomedical Imaging and Bioengineering; National Institute of Drug Abuse; National Institute of Mental Health; National Institute of Neurological Disorders and Stroke; Neurology; Organ; Positron-Emission Tomography; Radiochemistry; Radiology Specialty; Rattus; Request for Proposals; Research; Research Personnel; Research Support; Resolution; Rodent; Slice; Stem cells; System; Testing; Therapeutic; Tissue Engineering; Tracer; United States; United States National Institutes of Health; base; design; graphical user interface; image reconstruction; improved; instrumentation; millimeter; molecular imaging; mouse model; multimodality; novel; oncology; pre-clinical; radiotracer; receptor; reconstruction; response; uptake

DESCRIPTION (provided by applicant): This proposal requests funding for the purchase of a Super Argus Positron Emission Tomography-Magnetic Resonance (PET-MR) imaging system made by Sedecal Inc. for preclinical small animal multimodal imaging to support the research efforts in the Department of Radiology at the Massachusetts General Hospital (MGH). The device is the first commercial preclinical microPET-MR system available in the United States, and has fully integrated state-of-the-art high-resolution PET and state-of-the-art high-resolution MR capabilities. The system transaxial field of view is 68 mm for both components allowing both mouse and rat imaging. The PET acquisition has sub-millimeter spatial resolution, the highest sensitivity per slice of any commercial system, and high uniformity. Optimized algorithms result in rapid reconstruction of less than 2 min for 3D OSEM and less than 5 sec for filtered back projection. The MR acquisition module is based on a novel cryogen-free design, superconducting 3T magnet, with magnetic gradient strength of 125mT/m. The system has an integrated graphical user interface for both PET and MR acquisitions. This scanner will significantly enhance the research efforts of a diverse group of NIH funded investigators. The system will provide high-resolution multimodal imaging capabilities for non-invasive serial evaluation of MR agent and PET radiotracer distribution to facilitate research in new multimodal molecular tracers; provide high resolution correlative anatomic MR images for early assessment of response to novel therapies evaluated with changes in radiotracer uptake measured at the sub-organ level; and provide a platform for testing novel multimodality kinetic modeling and improved image reconstruction algorithms. The system has three major advantages over separate PET and MR devices for rodent imaging. First, the combined device can achieve temporal resolution for both modalities not attainable if animals are required to be moved between imaging systems; this is vital for both multimodal agent development and multimodal kinetic modeling. Second, spatial co-localization is greatly improved with a combined system, which is vital for brain receptor studies and assessment of genetically engineered mouse models of disease. Third, throughput is greatly enhanced without the need to move animals between systems, improving data collection. The application contains projects that comprise a broad base of users representing various disciplines (radiology/nuclear medicine, chemistry/radiochemistry, oncology, neurology, genetically engineered mouse modeling, kinetic modeling, image reconstruction, therapeutic stem cell delivery, and tissue engineering) and NIH funding sources (NCI, NIBIB, NHLBI, NINDS, NIDA, NIMH, NIAMS).The necessary administrative and technical direction is already in place to ensure efficient utilization of this instrumentation. This will be the first such system, commercial or otherwise, in the greater Boston area. It will provide a platform to test developed agents and imaging paradigms that will complement the human PET-MR efforts at MGH, and will be major asset to a large community of NIH funded investigators in the region.

描述（由申请人提供）：该提案要求购买超级Argus正电子发射层析成像 - 磁共振共鸣（PET-MR）成像系统，由Sedecal Inc.为临床前小型动物多模式成像，以支持部门的研究工作马萨诸塞州综合医院（MGH）的放射学。该设备是美国第一个商业临床前微型MR系统，并且具有完全集成的最先进的高分辨率宠物和最先进的高分辨率高分辨率MR功能。对于允许小鼠和大鼠成像的两个组件，系统持续视场均为68 mm。宠物采集具有亚毫米空间分辨率，任何商业系统的每片最高灵敏度和高均匀性。优化的算法导致3D OSEM的快速重建小于2分钟，而对后部投影的速度小于5秒。 MR采集模块基于一种新型的无低温设计，超导3T磁铁，磁性梯度强度为125mt/m。该系统具有PET和MR采集的集成图形用户界面。该扫描仪将大大增强一群由NIH资助的研究人员组成的研究工作。该系统将提供高分辨率的多模式成像能力，用于对MR剂和PET放射性分布的非侵入性串行评估，以促进新的多峰分子示踪剂的研究；提供高分辨率相关的解剖学MR图像，以早日评估对新疗法的反应，并在子管道水平上测得的放射性示意剂摄取的变化；并提供一个平台，用于测试新型的多模式动力学建模和改进的图像重建算法。该系统比单独的PET和MR设备具有三个主要优势，用于啮齿动物成像。首先，如果需要在成像系统之间移动动物，则组合设备可以实现两种方式的时间分辨率。这对于多模式剂的发展和多模式动力学建模至关重要。其次，通过组合系统可以大大改善空间共定位，这对于脑受体研究和评估疾病的基因工程小鼠模型至关重要。第三，无需在系统之间移动动物，从而改善数据收集，大大增强了吞吐量。该应用程序包含的项目包括代表各种学科的广泛用户（放射学/核医学，化学/放射化学，肿瘤学，神经病学，基因工程的小鼠建模，动力学建模，图像重建，治疗干细胞的递送和NIH）和NIH资金来源（NCI，NIBIB，NHLBI，NINDS，NIDA，NIMH，NIAMS。这将是大波士顿地区的第一个商业或其他系统。它将提供一个平台来测试已发达的代理商和成像范式，以补充MGH的人类PET-MR工作，并将成为该地区NIH资助的大型研究人员的主要资产。