Investigating the unification of supramolecular and organometallic catalysis for new reaction development

研究超分子和有机金属催化的统一以开发新反应

基本信息

批准号：
9792259
负责人：
Trandon Allen Bender
金额：
$ 6.16万
依托单位：
UNIVERSITY OF CALIFORNIA BERKELEY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-30 至 2021-09-29
项目状态：
已结题

项目摘要

The development of organometallic catalysts that exhibit good reactivity while concurrently offering chemoselectivity between similar functional groups are often at odds with one another. These challenges culminate when preparing biologically important molecules or modifying existing scaffolds to investigate structure activity relationships as these high-value substrates often contain functional groups with cross reactivity. The ability to develop catalysts capable of performing precise modifications remains a highly sought after goal in academic and industrial research. Demonstration of these protocols represents a major triumph in catalyst design and synthesis which leads to the next generation of biologically relevant compounds with life-saving properties. This proposal outlines a strategy that combines organometallic catalysis with supramolecular clusters to circumnavigate the inherent issues of cross reactivity and achieve chemoselective and ultimately enantioselective transformation on complex molecular scaffolds. Supramolecular clusters have a demonstrated ability to endow unique reactivity in organic and organometallic transformations through a dynamic microenvironment that benefits from numerous non-covalent interactions. Inspired by these successes, the research program outlined in this proposal offers two paths which build from promising initial results I have gathered. Ultimately, the investigation of enantioselective transformation will reveal the non-covalent interactions of a supramolecular cluster and organometallic catalysts, yielding a unique view of how dynamic microenvironments influence catalysis. The proposed research ultimately seeks to develop methods that will facilitate the preparation and modification of structurally complex medicinally relevant molecules in a novel way concomitantly expanding scientific knowledge.

开发具有良好反应活性的有机金属催化剂同时在相似的官能团之间提供化学选择性通常与一种不一致其他。当制备生物学上重要的分子或修改现有支架以研究结构活动关系，因为这些高价值底物通常含有具有交叉反应性的官能团。有能力开发能够进行精确修饰的催化剂仍然是一个备受追捧的目标学术和工业研究。这些协议的演示代表了重大胜利催化剂设计和合成导致下一代生物相关化合物具有救生特性。该提案概述了结合有机金属的策略超分子簇催化可以解决交叉反应的固有问题反应性并实现复杂的化学选择性和最终对映选择性转化分子支架。超分子簇具有赋予独特反应性的能力通过动态微环境进行有机和有机金属转化受益于许多非共价相互作用。受这些成功的启发，研究本提案中概述的计划提供了两条路径，从有希望的初始我收集的结果。最终，对映选择性转化的研究将揭示超分子簇和有机金属的非共价相互作用催化剂，产生动态微环境如何影响催化的独特观点。这拟议的研究最终旨在开发有助于准备的方法以新颖的方式修饰结构复杂的医学相关分子同时扩大科学知识。