Multi-Modality, Quantitative MRI to Assess the Human Optic Nerve in vivo

多模态定量 MRI 评估体内人类视神经

• 批准号: 8266270
• 负责人: Seth A Smith
• 金额: $ 13.3万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-19 至 2014-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8266270
• 关键词: Anisotropy; Area; Biological Markers; Brain; Clinic; Clinical; Data; Diagnosis; Diffusion; Diffusion Magnetic Resonance Imaging; Etiology; Evaluation; Evolution; Functional disorder; Goals; Human; Image; Inflammation; Legal patent; Magnetic Resonance Imaging; Magnetism; Maxillary Sinus; Measures; Methodology; Methods; Metric; Microscopic; Modality; Morphologic artifacts; Motion; Myelin; Optic Nerve; Optic Neuritis; Optical Coherence Tomography; Pathology; Patients; Predisposition; Recording of previous events; Reproducibility; Resolution; Scheme; Sensitivity and Specificity; Staging; Structure; Symptoms; Thick; Time; Tissues; Visual; Visual Acuity; base; effective therapy; healthy volunteer; in vivo; retinal nerve fiber layer

DESCRIPTION (provided by applicant): Optic Neuritis, marked by idiopathic, sudden inflammation of the optic nerve (ON), is the most commonly presenting symptom of MS. An estimated 50% of MS patients have a history of optic neuritis, which often resolves with time, and there are no effective treatments. However, its mere presence can be a signature of the early stages of MS, which, even with resolved clinical symptoms, could represent devastating axonal and myelin pathology. Our first hypothesis is that assessment of the optic nerve using MRI methods sensitive to axonal and myelin integrity can provide quantitative information about microscopic tissue changes in the ON of patients with MS. Our second hypothesis is that these metrics can be related to measures of the retinal nerve fiber layer (optical coherence tomography [OCT]) thickness, and visual dysfunction (low contrast visual acuity). Our overall goal is to devise and validate a multi-modality, myelin and axonal sensitive set of MR metrics for routine application in the clinic to study overt and silent ON damage in MS patients with and without history of optic neuritis. To accomplish our goal, we have set the following specific Aims. Aim 1: To develop Diffusion Tensor Imaging (DTI) and Magnetization Transfer (MT) imaging for the ON, a structure whose size, constant motion and proximity to the maxillary sinuses (increased magnetic susceptibility artifacts) has hampered DTI and MT methods. The reproducibility of the derived DTI and MT metrics will be assessed in healthy controls. Aim 2: To assess the ability of the DTI and MT schemes to detect pathology in patients with MS who have history of optic neuritis. Patient data will be compared with the healthy volunteer data obtained in AIM 1, and the sensitivity and specificity for ON damage will be assessed. Aim 3: To relate MT and DTI-derived metrics of the ON in MS patents with and without history of optic neuritis to 1) retinal nerve fiber layer thickness as determined by OCT and 2) low-contrast visual acuity assessed in the clinic. RELEVANCE: It is known that 17-20% of patients who present with optic neuritis eventually develop MS. The relevance is that quantitative diffusion and magnetization transfer MRI evaluation of the microstructure of the optic nerve (ON) in MS with or without history of optic neuritis may provide an earlier biomarker for MS and the evolution of MS. These methods should be applicable to other ON pathologies, and other difficult CNS tissues outside the brain.

描述（由申请人提供）：视发性，视神经突然炎症（ON）的标志性神经炎是MS的最常见症状。估计有50％的MS患者患有视神经炎的病史，通常会随着时间的流逝而解决，并且没有有效的治疗方法。但是，它的存在可能是MS早期阶段的签名，即使有解决的临床症状，也可能代表毁灭性的轴突和髓磷脂病理。我们的第一个假设是，使用对轴突和髓磷脂完整性敏感的MRI方法评估视神经可以提供有关MS患者ON中微观组织变化的定量信息。我们的第二个假设是，这些指标可能与视网膜神经纤维层（光学相干断层扫描[OCT]）厚度和视觉功能障碍（低对比度视力）的度量有关。我们的总体目标是设计和验证多模式，髓鞘和轴突敏感的MR指标集，用于在诊所进行常规应用，以研究有或没有视觉神经炎病史的MS患者的公开损害。为了实现我们的目标，我们设定了以下特定目标。目标1：开发扩散张量成像（DTI）和磁化转移（MT）成像，该结构的大小，恒定运动和与上颌鼻窦的稳定性（增加的磁敏感性伪像）的结构阻碍了DTI和MT方法。派生的DTI和MT指标的可重复性将在健康对照中进行评估。目的2：评估DTI和MT方案在患有视神经炎病史的患者中检测病理学的能力。将将患者数据与AIM 1中获得的健康志愿者数据进行比较，并评估损害的敏感性和特异性。 AIM 3：将具有和没有视觉神经炎病史的MS专利的MT和DTI衍生的指标与1）视网膜神经纤维层厚度相关联，如OCT和2）在诊所中评估的低对比度视力。 关联： 众所周知，患有视神经炎的患者中有17-20％最终发展为MS。相关性是定量扩散和磁化转移MRI评估视神经的微观结构 （ON）在有或没有视觉神经炎史的MS中，可能会为MS提供早期的生物标志物和MS的演变。这些方法应适用于其他病理，以及大脑外部的其他困难中枢神经系统组织。