Cardiovascular Risk and Insulin Resistance: Age 7-40

心血管风险和胰岛素抵抗：7-40 岁

• 批准号: 7650119
• 负责人: Julia Steinberger
• 金额: $ 59.56万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7650119
• 关键词: 10 year old; 6 year old; Adolescence; Adult; Age; Anthropometry; Atherosclerosis; Behavior; Biological; Blood Pressure; Blood Vessels; Body mass index; Cardiovascular Diseases; Cardiovascular system; Carotid Arteries; Child; Childhood; Clinical; Cohort Studies; Data; Development; Diet; Disease; Environmental Risk Factor; Epidemic; Exhibits; Family; Fasting; Fatty acid glycerol esters; Generations; Genetic; Glucose; Goals; HDL-triglyceride; Height; Hyperinsulinism; Indium; Individual; Inflammation; Inflammatory; Insulin; Insulin Resistance; Intervention; Life; Life Style; Lipids; Measures; Mediating; Metabolic; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Oxidative Stress; Parents; Pattern; Physical activity; Recruitment Activity; Research; Research Personnel; Research Proposals; Risk; Risk Factors; Schools; Smoking; Testing; Thick; Visceral; Waist-Hip Ratio; Weight; abdominal fat; brachial artery; cardiovascular risk factor; cohort; early childhood; effective intervention; emerging adult; fasting glucose; high risk; high school; intima media; lifestyle factors; obesity in children; offspring; programs; trend; vascular factor; waist circumference

DESCRIPTION (provided by applicant): This research application will use an already established cohort to investigate the early development of obesity, insulin resistance, and their interaction with associated cardiovascular (CV) risk factors in a cross- generational study between parents (generation 1), on whom we have long-term repeated observations from age 7 to 40, and their children (generation 2). The underlying hypotheses are that early adiposity and insulin resistance drive the development of CV risk and that children, by sharing genetic and environmental factors with their parents, exhibit a similar risk profile for development of type 2 diabetes and atherosclerotic CV disease. Our access to a cohort of individuals who were initially recruited in early childhood, followed through adolescence and young adulthood and currently have children equivalent in age to their own age when they were first recruited, offers a unique opportunity to test this hypothesis. The major objective of this application is to relate individual CV risk factors (hyperinsulinemia, blood pressure, obesity, lipids), lifestyle behaviors, visceral fat (abdominal CT), measures of inflammation, adipocytokines, oxidative stress, vascular studies, and specific measures of insulin resistance (euglycemic hyperinsulinemic clamps) between generations by comparing findings in the parents (generation 1, when they were children and at their current adult age) with their children (generation 2). Overt cardiovascular disease is rare in children, but the factors associated with its development are present early in life. Thus, this study will document the importance, in this current era of epidemic obesity and type 2 diabetes mellitus (T2DM), of identifying high-risk families and children in order to introduce effective intervention strategies prior to disease development. Delineation of similarities in the elements of CV risk between parents and their children and identification of markers that predict which children are at risk for metabolic and cardiovascular complications are the initial steps to achieve this clinical scientific goal.

描述（由申请人提供）：本研究申请将使用已经建立的队列研究肥胖，胰岛素抵抗的早期发展，以及它们与父母之间的跨世代研究中的相关性（CV）危险因素（1代）（1代），我们对我们的长期重复观察到了7至40岁，及其子女（他们的孩子）及其孩子（2代）。潜在的假设是，早期肥胖和胰岛素抵抗可以推动简历风险的发展，而儿童通过与父母共享遗传和环境因素，在2型糖尿病和动脉粥样硬化CV疾病的发展方面具有相似的风险。我们进入一群最初在童年时期招募的人，随后是青春期和成年后的，目前有年龄在自己的年龄中，他们首次被招募时就等同于自己的年龄，这提供了一个独特的机会来检验这一假设。该应用的主要目的是关联单个CV风险因素（高胰岛素血压，血压，肥胖，脂质），生活方式行为，内脏脂肪（腹部CT），炎症的测量，脂肪细胞因子，氧化应激，氧化应激，血管性抑制作用以及胰岛素抑制作用（Egeneral pecartion）（欧生蛋白（Eugulinc）的特定水平） 1，当他们是孩子的时候，当前成年时代）与孩子（第2代）。在儿童中，明显的心血管疾病很少见，但是与其发育相关的因素在生命的早期存在。因此，这项研究将记录到当前流行肥胖症和2型糖尿病（T2DM）的重要性，即确定高风险家庭和儿童，以便在疾病发展之前引入有效的干预策略。在父母及其子女之间的简历风险元素中的相似性以及预测哪些儿童有代谢和心血管并发症风险的标记是实现这一临床科学目标的初始步骤。