Steady-State Sequences for Metabolic Imaging with Hyperpolarized Carbon-13

超极化碳 13 代谢成像的稳态序列

• 批准号: 8228578
• 负责人: Aaron Keith Grant
• 金额: $ 21.75万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-15 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8228578
• 关键词: Acceleration; Adopted; Bicarbonates; Blood Volume; Blood flow; Carbon; Cell Nucleus; Chemical Shift Imaging; Chemicals; Development; Diagnosis; Dimensions; Disease; Equilibrium; Fatty acid glycerol esters; Frequencies; Image; Imaging Device; Individual; Intervention; Label; Magnetic Resonance Imaging; Malignant Neoplasms; Measures; Metabolic; Metabolism; Methods; Modification; Monitor; NMR Spectroscopy; Noise; Pathway interactions; Performance; Perfusion; Pharmaceutical Preparations; Phase; Pilot Projects; Play; Protons; Pyruvate; Randomized; Reading; Relative (related person); Renal Cell Carcinoma; Resolution; Role; Scanning; Series; Signal Transduction; Slice; Spectrum Analysis; Speed; Techniques; Thick; Time; Tissues; Validation; Water; Work; Xenograft Model; antiangiogenesis therapy; base; cancer therapy; design; experience; imaging modality; improved; in vivo; interest; new technology; novel; novel strategies; reconstruction; spectroscopic imaging; tert-Butyl Alcohol; tool; tumor; tumor xenograft; two-dimensional; uptake; Acceleration; Adopted; Bicarbonates; Blood Volume; Blood flow; Carbon; Cell Nucleus; Chemical Shift Imaging; Chemicals; Development; Diagnosis; Dimensions; Disease; Equilibrium; Fatty acid glycerol esters; Frequencies; Image; Imaging Device; Individual; Intervention; Label; Magnetic Resonance Imaging; Malignant Neoplasms; Measures; Metabolic; Metabolism; Methods; Modification; Monitor; NMR Spectroscopy; Noise; Pathway interactions; Performance; Perfusion; Pharmaceutical Preparations; Phase; Pilot Projects; Play; Protons; Pyruvate; Randomized; Reading; Relative (related person); Renal Cell Carcinoma; Resolution; Role; Scanning; Series; Signal Transduction; Slice; Spectrum Analysis; Speed; Techniques; Thick; Time; Tissues; Validation; Water; Work; Xenograft Model; antiangiogenesis therapy; base; cancer therapy; design; experience; imaging modality; improved; in vivo; interest; new technology; novel; novel strategies; reconstruction; spectroscopic imaging; tert-Butyl Alcohol; tool; tumor; tumor xenograft; two-dimensional; uptake

DESCRIPTION (provided by applicant): Hyperpolarization of carbon-13 is a new technology that dramatically enhances the sensitivity of NMR spectroscopy. Hyperpolarized MR imaging can monitor both the uptake and the subsequent metabolic transformations of substrates such as pyruvate, enabling new approaches to diagnosis and treatment monitoring of cancer and other diseases. At present, widely used imaging methods based on echo planar spectroscopic imaging (EPSI) or two-dimension chemical shift imaging (2D CSI) offer relatively limited spatial resolution, which limits the applications of these methods and complicates image interpretation. In addition, blood volume and blood flow play an important role in determining local signal intensity, partially obscuring the effects of metabolism. This proposal describes the development of new imaging methods that exploit the sparsity of hyperpolarized 13C spectra to acquire chemical-shift selective images with high spatial and temporal resolution. These methods are based on steady-state free-precession (SSFP) imaging sequences, which can be readily modified to obtain images that modulate the relative magnitude and phase of signals from different metabolites, thereby enabling the reconstruction of individual images of each metabolite. These techniques will be optimized using phantom and in vivo studies and then compared with conventional 2D CSI methods to validate their performance. The methods will then be applied to simultaneous imaging of perfusion and metabolism in a xenograft model of renal cell carcinoma. Completion of these studies will provide valuable new tools for the study and development of novel treatments for cancer, including anti-angiogenesis drugs and metabolic interventions. PUBLIC HEALTH RELEVANCE: Hyperpolarization is a new technology that dramatically enhances the sensitivity of magnetic resonance imaging, providing new tools for imaging metabolism and blood flow in cancer and other diseases. This proposal is aimed at developing new techniques that will increase the speed and resolution of hyperpolarized imaging. These methods will be validated by comparison with older techniques, and applied to imaging of blood flow and metabolism in cancer.

描述（由申请人提供）：碳13的超极化是一种新技术，可显着增强NMR光谱的灵敏度。超极化的MR成像可以监测丙酮酸等底物的摄取和随后的代谢转化，从而为癌症和其他疾病的诊断和治疗监测提供了新的方法。目前，基于回声平面光谱成像（EPSI）或二维化学移位成像（2D CSI）的广泛使用的成像方法提供了相对有限的空间分辨率，这限制了这些方法的应用并使图像解释复杂化。此外，血容量和血流在确定局部信号强度方面起着重要作用，部分掩盖了代谢的影响。该建议描述了开发新成像方法，这些方法利用了超极化13C光谱的稀疏性，以获得具有高空间和时间分辨率的化学班次选择性图像。这些方法基于稳态自由报（SSFP）成像序列，可以很容易地修改以获取从不同代谢物调节信号的相对大小和相位的图像，从而实现了每个代谢物的各个图像的重建。这些技术将使用幻影和体内研究优化，然后与常规2D CSI方法进行比较以验证其性能。然后，该方法将应用于肾细胞癌的异种移植模型中灌注和代谢的同时成像。这些研究的完成将为研究和开发新的癌症治疗方法（包括抗血管生成药物和代谢干预措施）提供宝贵的新工具。 公共卫生相关性：超极化是一项新技术，可显着增强磁共振成像的敏感性，为癌症和其他疾病中的代谢和血液流动提供新工具。该建议旨在开发新技术，以提高超极化成像的速度和分辨率。这些方法将通过与较旧技术进行比较来验证，并应用于癌症中血流和代谢的成像。