Steady-State Sequences for Metabolic Imaging with Hyperpolarized Carbon-13

超极化碳 13 代谢成像的稳态序列

• 批准号: 8228578
• 负责人: Aaron Keith Grant
• 金额: $ 21.75万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-15 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8228578
• 关键词: Acceleration; Adopted; Bicarbonates; Blood Volume; Blood flow; Carbon; Cell Nucleus; Chemical Shift Imaging; Chemicals; Development; Diagnosis; Dimensions; Disease; Equilibrium; Fatty acid glycerol esters; Frequencies; Image; Imaging Device; Individual; Intervention; Label; Magnetic Resonance Imaging; Malignant Neoplasms; Measures; Metabolic; Metabolism; Methods; Modification; Monitor; NMR Spectroscopy; Noise; Pathway interactions; Performance; Perfusion; Pharmaceutical Preparations; Phase; Pilot Projects; Play; Protons; Pyruvate; Randomized; Reading; Relative (related person); Renal Cell Carcinoma; Resolution; Role; Scanning; Series; Signal Transduction; Slice; Spectrum Analysis; Speed; Techniques; Thick; Time; Tissues; Validation; Water; Work; Xenograft Model; antiangiogenesis therapy; base; cancer therapy; design; experience; imaging modality; improved; in vivo; interest; new technology; novel; novel strategies; reconstruction; spectroscopic imaging; tert-Butyl Alcohol; tool; tumor; tumor xenograft; two-dimensional; uptake

DESCRIPTION (provided by applicant): Hyperpolarization of carbon-13 is a new technology that dramatically enhances the sensitivity of NMR spectroscopy. Hyperpolarized MR imaging can monitor both the uptake and the subsequent metabolic transformations of substrates such as pyruvate, enabling new approaches to diagnosis and treatment monitoring of cancer and other diseases. At present, widely used imaging methods based on echo planar spectroscopic imaging (EPSI) or two-dimension chemical shift imaging (2D CSI) offer relatively limited spatial resolution, which limits the applications of these methods and complicates image interpretation. In addition, blood volume and blood flow play an important role in determining local signal intensity, partially obscuring the effects of metabolism. This proposal describes the development of new imaging methods that exploit the sparsity of hyperpolarized 13C spectra to acquire chemical-shift selective images with high spatial and temporal resolution. These methods are based on steady-state free-precession (SSFP) imaging sequences, which can be readily modified to obtain images that modulate the relative magnitude and phase of signals from different metabolites, thereby enabling the reconstruction of individual images of each metabolite. These techniques will be optimized using phantom and in vivo studies and then compared with conventional 2D CSI methods to validate their performance. The methods will then be applied to simultaneous imaging of perfusion and metabolism in a xenograft model of renal cell carcinoma. Completion of these studies will provide valuable new tools for the study and development of novel treatments for cancer, including anti-angiogenesis drugs and metabolic interventions. PUBLIC HEALTH RELEVANCE: Hyperpolarization is a new technology that dramatically enhances the sensitivity of magnetic resonance imaging, providing new tools for imaging metabolism and blood flow in cancer and other diseases. This proposal is aimed at developing new techniques that will increase the speed and resolution of hyperpolarized imaging. These methods will be validated by comparison with older techniques, and applied to imaging of blood flow and metabolism in cancer.

描述（由申请人提供）：碳13超极化是一项新技术，可显着提高核磁共振波谱的灵敏度。超极化磁共振成像可以监测丙酮酸等底物的摄取和随后的代谢转化，从而为癌症和其他疾病的诊断和治疗监测提供新方法。目前，广泛使用的基于回波平面光谱成像（EPSI）或二维化学位移成像（2D CSI）的成像方法提供的空间分辨率相对有限，这限制了这些方法的应用并使图像解释复杂化。此外，血容量和血流量在确定局部信号强度方面发挥着重要作用，部分掩盖了新陈代谢的影响。该提案描述了新成像方法的开发，该方法利用超极化 13C 光谱的稀疏性来获取具有高空间和时间分辨率的化学位移选择性图像。这些方法基于稳态自由进动 (SSFP) 成像序列，可以轻松修改该序列以获得调制不同代谢物信号的相对幅度和相位的图像，从而能够重建每种代谢物的单个图像。这些技术将使用模型和体内研究进行优化，然后与传统的 2D CSI 方法进行比较以验证其性能。然后，该方法将应用于肾细胞癌异种移植模型中灌注和代谢的同步成像。这些研究的完成将为研究和开发癌症新疗法（包括抗血管生成药物和代谢干预措施）提供有价值的新工具。 公共健康相关性：超极化是一项新技术，可显着提高磁共振成像的灵敏度，为癌症和其他疾病的代谢和血流成像提供新工具。该提案旨在开发新技术，提高超偏振成像的速度和分辨率。这些方法将通过与旧技术的比较来验证，并应用于癌症血流和代谢的成像。