Drug Abuse Vulnerability: Mechanisms and Manifestations

药物滥用脆弱性：机制和表现

基本信息

批准号：
8699322
负责人：
RALPH E TARTER
金额：
$ 10万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-05-01 至 2015-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8699322
关键词：
12 year old Administrator Age Alcohol or Other Drugs use Alcohols Applications Grants Basic Science Behavior Biological Books Budgets Caffeine Cannabis Categories Characteristics Child Clinical Clinical Engineering Clinical Research Collaborations Consumption DSM-IV Data Daughter Development Diagnostic Discipline Disease Doctor of Medicine Doctor of Philosophy Drug abuse Drug usage Eating Education Enrollment Ensure Environment Environmental Risk Factor Ethics Etiology Evaluation Event Exercise Expenditure Faculty Family Family member Fathers Frequencies Funding Genetic Goals Grant Guide prevention Illicit Drugs Individual Interdisciplinary Study Investigation Journals K-Series Research Career Programs Laws Leadership Legal Link Literature Master of Public Health Measurement Mental disorders Mission Modeling Monitor Mothers NIH Program Announcements Names National Institute of Drug Abuse National Institute of Neurological Disorders and Stroke Neurobiology Nursing Faculty Outcome Pattern Pharmaceutical Preparations Pilot Projects Policies Populations at Risk Postdoctoral Fellow Prevention Procedures Process Protocols documentation Provider Psychological reinforcement Psychopathology Publications Recommendation Recruitment Activity Research Research Institute Research Training Resources Review Committee Risk Safety Science Services Severities Son Staging Stepparent Students Substance Use Disorder Supervision System Testing Time Tobacco Training Training and Education Translations United States National Institutes of Health Variant Youth addiction arm base biobehavior design didactic education drug abuse education endophenotype experience follow-up foot high risk human disease illegal behavior implementation research indexing insight instrumentation men neurogenetics non-drug offspring proband programs prospective psychologic public health relevance response social norm statistics theories transmission process

项目摘要

DESCRIPTION (provided by applicant): This competing renewal application proposes to continue the follow-up research on 775 families enrolled in the Center's prospective investigations into the etiology of substance use disorder (SUD). The probands are men with lifetime presence/absence of SUD consequent to use of an illicit drug who have a 10-12 year old biological son or daughter. The biological children of SUD men are assigned to the high average risk (HAR) group whereas offspring of men without SUD, having neither axis 1 disorder ("normal") nor SUD psychiatric disorder, are assigned to the low average risk (LAR) groups. These children are currently in varying stages of follow-up evaluation conducted at ages 12-14, 16, 19, and annually thereafter until age 30. We have already shown that we can predict in 10-12 year old youth cannabis use disorder by age 22 with approximately 70% accuracy, thereby substantiating the paradigm, subject recruitment strategy and measurement protocols. Multidisciplinary research is conducted on family members (father, mother, children, step-parents) with the objective of elucidating the genetic, biobehavioral and environmental factors on development of SUD consequent to use of illegal drugs. Research protocols are organized into three thematically connected research modules (Neurogenetics. Developmental Psychopathology, and Translation) linking etiology and prevention. The research components thus align with the NIH Roadmap model such that basic science informs clinical research leading to prevention guided by an understanding of etiology. In addition to module-level research, faculty also participate in 3 centerwide aims: 1) Devise a practical scale to quantify the transmissible liability to SUD; 2) Empirically test a biopsychological theory of SUD etiology focusing on off time maturation leading to psychological dysregulation predisposing to SUD; and, 3) Delineate SUD liability variants within an ontogenetic framework. The Center has the program name Center for Education and Drug Abuse Research (CEDAR). It consists of six components (3 cores & 3 research modules): 1) Science Administration (R. Tarter, Ph.D.), 2) Clinical Core (J. Cornelius, M.D.), 3) Statistics Core (L. Kirisci, Ph.D.), 4) Neurogenetics Module (M. Vanyukov, Ph.D.) 5) Developmental Psychopathology Module (D. Clark, M.D., Ph.D.), and 6) Translation Module (Ty Ridenour, Ph.D.). Vertical and horizontal integration of the Center's components promote collaborative research encompassing multiple disciplines. To date, this research program has supported over 360 publications, 4 books, and 3 special journal issues as well as the training of numerous students, faculty and fellows. Six K awards are currently funded using CEDAR resources.

描述（由申请人提供）：这种竞争性更新申请建议继续对该中心对物质使用障碍病因的前瞻性调查的775个家庭进行的后续研究（SUD）。这些概率是男性，终生存在/缺乏SUD，因此使用具有10至12岁的亲生儿子或女儿的非法药物。 SUD男性的生物儿童被分配到高平均风险（HAR）组，而没有SUD的男性的后代，既没有轴1障碍（“正常”）和SUD精神病障碍，被分配到低平均风险（LAR）组。这些孩子目前处于在12-14、16、19、19、19岁和此后每年进行的随访评估的不同阶段。我们已经表明，我们可以预测到22岁的10-12岁青年大麻使用障碍，其准确性约为70％，从而实现了范式，招募策略和测量策略和测量协议。多学科研究是针对家庭成员（父亲，母亲，儿童，继父母）进行的，目的是阐明遗传，生物行为和环境因素，用于使用非法药物的SUD的发展。研究方案分为三个主题联系的研究模块（神经遗传学，发育心理病理学和翻译），将病因和预防联系起来。因此，研究组件与NIH路线图模型保持一致，因此基础科学会为临床研究提供信息，从而导致对病因的理解为指导。除了模块级研究外，教师还参与了3个核心目标：1）设计一个实用量表来量化对SUD的可传染性责任； 2）从经验上测试SUD病因的生物心理学理论，重点是时间成熟，导致心理失调障碍易于SUD； 3）在一个遗传框架内描述SUD责任变体。该中心设有教育和药物滥用研究中心（CEDAR）。它由六个组成部分（3个核心和3个研究模块）组成：1）科学管理（R. Tarter，Ph.D.），2）临床核心（J. Cornelius，M.D。），3）统计核心（L. Kirisci，Ph.D. 6）翻译模块（Ty Ridenour，博士）。该中心组件的垂直和水平整合促进了包括多个学科的协作研究。迄今为止，该研究计划已支持360多个出版物，4本书和3个特殊期刊问题，以及对众多学生，教职员工和研究员的培训。目前使用Cedar Resources资助六个K奖项。