Examining Population Coding Underlying Complex Behavior in Freely Moving Primates

检查自由活动的灵长类动物复杂行为背后的群体编码

• 批准号: 8541055
• 负责人: VALENTIN DRAGOI
• 金额: $ 72.02万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2015-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8541055
• 关键词: Animals; Attention; Behavior; Biological Neural Networks; Brain; Brain Diseases; Code; Complex; Data; Decision Making; Environment; Head; Hearing; Individual; Laboratories; Lead; Learning; Life; Measures; Medical; Memory; Neurons; Population; Primates; Property; Prosthesis; Sleep; Social Behavior; Stimulus; System; Technology; Vision; Wireless Technology; computer monitor; insight; interest; new technology; nonhuman primate; practical application; relating to nervous system; response

ABSTRACT I propose a new technology that will fundamentally change our understanding of brain function and the relationship with behavior. Examining complex functions, such as vision, hearing, memory, attention, decision making, or sleep, have been traditionally performed by studying the brain of nonhuman primates in a laboratory environment in which the head and body are restrained while synthetic stimuli are presented on a computer monitor. However, it has become increasingly understood that studying the brain in a restrained laboratory rig poses severe limits on our capacity to understand the function of brain circuits. Indeed, when responses of individual neurons are measured in naturalistic settings they tend to be different compared to when they are measured in the laboratory environment. In addition, it has always been unclear whether phenomena well described in laboratory conditions, such as adaptation, learning, or decision making, can be replicated when animals freely move in their natural environment. To overcome these limitations, I will construct a wireless system that will allow neuroscientists to study cortical dynamics and plasticity at the population level while nonhuman primates are moving freely in their natural environment. Studying brain function in an unconstrained environment will open new opportunities. Phenomena that were difficult or impossible to observe in an experimental rig, such as foraging, sleep, or social behavior will now become possible to study. Our technology will allow us to acquire vastly more brain data than has ever been gathered in live subjects, at a much higher rate than is possible today. The large quantity of contiguous neural data recorded by such a system will be of great interest to clinicians and theorists studying general properties of normal and dysfunctional neural networks. Our system will lead not only to medical insights into the mechanisms of brain disorders, but also to practical applications for neuronal prosthetic devices.

抽象的 我提出了一项新技术，从根本上讲，我们对大脑功能的理解和 与行为的关系。检查复杂功能，例如视觉，听力，记忆，注意力，决策 传统上，通过研究实验室中的非人类灵长类动物的大脑来制作或睡眠 在计算机上呈现合成刺激时，头部和身体受到约束的环境 监视器。但是，已经越来越了解，在约束实验室钻机中研究大脑 对我们了解脑电路功能的能力构成严重限制。确实，当回应的回应 在自然主义环境中测量单个神经元与它们相比，它们往往会不同 在实验室环境中测量。另外，始终尚不清楚现象是否很好 在实验室条件（例如适应，学习或决策）中描述的时候可以复制 动物在自然环境中自由移动。为了克服这些限制，我将构建一个无线 将允许神经科学家研究皮质动力学和可塑性的系统，而 非人类灵长类动物正在自然环境中自由移动。在不受约束的 环境将为新的机会开放。在一个困难或不可能观察到的现象 实验性钻机（例如觅食，睡眠或社会行为）现在可以学习。我们的技术 将使我们获得的大脑数据比在现场主题中收集到的大脑数据要多得多 比率比今天的可能性。该系统记录的大量连续神经数据将为 对正常和功能障碍神经的一般特性的临床医生和理论家的极大兴趣 网络。我们的系统不仅会导致对脑部疾病机制的医学见解，而且还会引起 神经元假体设备的实际应用。