OUHSC Specific Pathogen Free Baboon Research Resource

OUHSC 无特定病原体狒狒研究资源

• 批准号: 8415585
• 负责人: Roman F. Wolf
• 金额: $ 78.6万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8415585
• 关键词: Adult; Animal Experimentation; Animal Model; Animals; Babesia; Behavioral Research; Biomedical Research; Birth; Breeding; DNA; DNA Markers; Development; Diagnostic tests; Disease Outbreaks; Exclusion; Extramural Activities; Female; Funding; Genes; Genetic; Genetic Variation; Genetic screening method; Genotype; Goals; Grant; Herpesviridae; Human; Infant; Infectious Agent; Intramural Research Program; Maintenance; Methods; Mission; Modeling; Monitor; Monoclonal Antibody R24; National Center for Research Resources; Nurseries; Oklahoma; Papio; Parasites; Phase; Population Sizes; Primates; Production; Recruitment Activity; Reproducibility; Research; Research Personnel; Research Project Grants; Research Support; Resources; Retroviridae; Source; Specific Pathogen Frees; Staging; Testing; United States; United States National Institutes of Health; Virus; analog; base; cost; genetic pedigree; genome analysis; germ free condition; improved; male; meetings; nonhuman primate; novel; offspring; pathogen; programs; public health relevance; statistics

DESCRIPTION (provided by applicant): The mission of the OUHSC Baboon Research Resource is to provide resources that support biomedical and behavioral research requiring the baboon as the animal model. A vital part of this mission is the production of Specific Pathogen Free (SPF) baboons. Unique in the world, the OUHSC SPF baboon program is poised to provide an indispensable nonhuman primate resource for biomedical research. The goal of this program is to complete development of an active, self-supporting breeding colony of baboons that are free of all five known baboon herpes viruses, four retroviruses, as well as a number of additional viruses and parasites. The developing program is already providing some SPF baboons to NIH-funded biomedical research programs, but cannot meet the demand for these unique animals. To complete development of this national resource we will recruit an additional 150 infants over five years into the SPF program. The genetic diversity of the colony will be assessed and monitored to maximize its genetic diversity. During this final phase of colony development, we will continue to provide 20-30 SPF baboons per year to NIH-funded research programs. To keep the colony outbred genetic testing will be performed and evaluated. Several research projects will also be supported by this program with the aim of improving the resource. The long term objective is for the SPF baboon colony to be a stable, self-sustaining breeding colony that produces ~100 SPF baboons/year for use in NIH-funded biomedical research.

描述（由申请人提供）：OUHSC狒狒研究资源的使命是提供支持生物医学和行为研究，要求狒狒作为动物模型。该任务的重要部分是生产特定的无病原体（SPF）狒狒。 OUHSC SPF狒狒计划在世界上独一无二，有望为生物医学研究提供必不可少的非人类灵长类动物资源。该计划的目的是完成积极，自支撑的狒狒繁殖菌落，其中含有所有五种已知的狒狒病毒，四种逆转录病毒以及许多其他病毒和寄生虫。发展计划已经为NIH资助的生物医学研究计划提供了一些SPF狒狒，但无法满足对这些独特动物的需求。为了完成该国家资源的发展，我们将在SPF计划中招募另外150名婴儿。将评估和监测菌落的遗传多样性，以最大程度地提高其遗传多样性。在殖民地发展的最后阶段，我们将继续为NIH资助的研究计划提供20至30次SPF狒狒。为了保持菌落概念，基因检测将进行和评估。该计划还将支持一些研究项目，以改善资源。长期目标是让SPF狒狒殖民地成为一个稳定的自我维持的繁殖菌落，可在NIH资助的生物医学研究中产生约100次SPF狒狒/年。