Genomic Resource Grant for PhenX Toolkit (U41)

PhenX 工具包基因组资源资助 (U41)

• 批准号: 8720131
• 负责人: Carol Marie Hamilton
• 金额: $ 78.06万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2017-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8720131
• 关键词: Address; Adoption; Aging; Area; Autistic Disorder; Awareness; Bioinformatics; Biomedical Research; Chinese People; Collaborations; Collection; Communities; Companions; Consensus; Data; Deposition; Educational workshop; Ensure; Exhibits; Federal Government; Fostering; Funding Opportunities; Genome; Genomics; Goals; Grant; Individual; Information Systems; Institutes; Journals; Maps; Measurement; Measures; Metric; Nature; Online Systems; Patient Outcomes Assessments; Pediatrics; Peer Review; Phenotype; Pilot Projects; Population; Process; Protocols documentation; Publications; Rare Diseases; Research; Research Design; Research Personnel; Resources; Staging; Substance Addiction; Substance abuse problem; Translations; United States National Institutes of Health; Update; Veterans; Work; base; cost; database of Genotypes and Phenotypes; genome wide association study; meetings; outreach; population based; programs; research study; social; standard measure; symposium; tool; web site; working group

"The PhenX Toolkit-Standard Measures for Genomics Research" will maintain and expand the PhenX Toolkit to meet the evolving needs of the scientific community. The Toolkit currently includes 21 research domains, and 7 collections of measures related to Substance Abuse and Addiction. The Toolkit has a broad user base, and PhenX measures are being included in ongoing studies. The goals of the proposed work are to address four new research domains, to implement a rolling review and update of the 21 research domains, to integrate Chinese and Spanish translations of Toolkit protocols, to expand into social media, to build on our collaboration with the database of Genotypes and Phenotypes (dbGaP), and to make PhenX measures visible in all completed studies deposited in dbGaP. We will also foster collaborations with related measures efforts (e.g., the Patient Reported Outcomes Measurement Information System [PROMIS] and the National Institutes of Health [NIH] Toolbox), highlighting the complementary nature of these approaches and identifying synergies. Taken together, these efforts will attract additional users to the Toolkit and raise awareness of the Toolkit as an important, helpful resource for the scientific community. Widespread adoption of PhenX measures will facilitate cross-study analysis, thus increasing the scientific impact of individual studies. With continued support, PhenX will promote and advance collaborative research across the biomedical research community.

“基因组学研究的苯苯苯克特工具包标准措施”将维护和扩展苯克斯工具包 满足科学界不断发展的需求。该工具包目前包括21个研究领域， 和7种与药物滥用和成瘾有关的措施。该工具包具有广泛的用户群， 正在进行的研究中包括和苯苯克；拟议工作的目标是解决 四个新的研究领域，以实施21个研究领域的滚动审查和更新，以整合 中文和西班牙的工具包协议翻译，以扩展到社交媒体，以我们的协作为基础 使用基因型和表型的数据库（DBGAP），并使所有可见的苯克斯措施可见 填写的研究沉积在DBGAP中。我们还将与相关措施的努力促进合作（例如 患者报告了结果测量信息系统[Promis]和国立研究所 健康[NIH]工具箱），强调了这些方法的互补性并确定协同作用。 综上所述，这些努力将吸引更多用户进入工具包，并提高对工具包的认识 对科学界的重要，有用的资源。广泛采用苯苯第二指标将有助于 跨研究分析，从而增加了个体研究的科学影响。在持续的支持下，苯克斯 将在整个生物医学研究界促进和推进合作研究。