HEPA Filtration on Reducing Cardiometabolic Risk During Wildfires

HEPA 过滤可降低野火期间的心脏代谢风险

基本信息

批准号：
10838186
负责人：
Zhanghua Chen
金额：
$ 62.09万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-01 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10838186
关键词：
Accounting Acer Acute Address Adverse effects Affect Age Air Air Conditioning Air Pollution Area Aromatic Polycyclic Hydrocarbons Biological Markers Blood Blood Pressure Blood Pressure Monitors Blood Vessels Blood specimen Burn injury California Cardiac Cardiovascular Diseases Cardiovascular system Clinical Coagulation Process Collection Country Cross-Over Trials Data Devices Diagnostic Reagent Kits Double-Blind Method Effectiveness Effectiveness of Interventions Elderly Emergency department visit Enrollment Epidemic Event Exposure to Filtration Fire - disasters Future Gelatinase B Health Health Benefit Home Home visitation Human Hypertension Incidence Individual Infiltration Inflammation Inflammatory Interdisciplinary Study Interleukin-6 Intervention Los Angeles Measurement Measures Mediating Metabolic Methods Modeling Monitor Myocardial Ischemia Noise Outcome Participant Particulate Patients Persons Population Predisposition Preventive Proteomics Questionnaires Recording of previous events Research Design Risk Sampling Seasons Series Shelter facility Smoke Source Statistical Data Interpretation Stress Surveys TNF gene Temperature Testing Thrombosis Time United States Urine VWF gene Wildfire aged air filtration arm arterial stiffness atherothrombosis behavior change cardiometabolic risk cardiometabolism cardiovascular effects cardiovascular health climate change climate impact cost digital digital health effectiveness evaluation epidemiology study exposed human population fine particles follow-up heart rate variability improved indoor air indoor exposure insight novel prevent public health relevance randomized trial remote monitoring response sensor tool wearable device wood smoke

项目摘要

ABSTRACT In this supplemental study, we propose to investigate the climate change effects on health, focusing specifically on the impact of wildland fire-enhanced air pollution on human health. The supplemental study will be built upon the ongoing SAPIA study, "Slowing Atherothrombosis Progression through Indoor Air Filtration," aiming to assess the effectiveness of HEPA filtration in reducing indoor PM2.5 exposure and the subsequent effects on improving atherothrombosis outcomes. The SAPIA study will enroll and follow up 52 participants aged 65-84 years old with ischemic heart disease history and living in the Los Angeles area in year 2023-2024. The aims of this supplemental study will extend the original SAPIA aims to focus on investigating adverse effects of wildfire exposures and assess the effectiveness of residential HEPA filtration in 1) reducing indoor exposure to PM2.5 during wildfire events and 2) alleviating the wildfire-induced adverse effects on acute cardiovascular outcomes (blood pressure, heart rate variability and biomarkers). We will use existing national and regional wildfire and air pollution monitoring networks to monitor wildfire events during the wildfire season (May-September). We will employ low-cost air quality sensors at participants' residential addresses to monitor indoor and outdoor PM2.5 levels. By using both time-series and dispersion models, we will validate the indoor and outdoor levels of wildfire- derived PM2.5 in both HEPA and non-HEPA settings. This approach will enable us to assess the effectiveness of HEPA filtration in reducing indoor PM2.5 concentrations. Once a wildfire event is identified, participants will be informed to complete questionnaires and collect urine and blood samples using pre-distributed and self-collection test kits. Daily blood pressure (BP) and heart rate variability will be remotely collected using Withings BP monitors and wearable Oura® rings. The advantages of this study include the use of a two-arm randomized trial nested within the ongoing SAPIA cross-over trial, wearable digital devices for real-time health monitoring, and self- collection of blood and urine samples, which enable the assessment of the acute health effects of wildfires. Findings of this study will help to assess the effectiveness of HEPA filtration as a preventive tool for the adverse health effects of wildfire-originated air pollution exposure. In conclusion, this supplemental study will contribute significantly to understanding the impact of climate change-enhanced wildfires on human health and the potential health benefits of HEPA filtration by reducing exposure to wildfire-originated PM2.5. By combining state-of-the- art exposure assessment methods, real-time health outcome monitoring and self-collection of biosamples, this study will provide valuable insights into the relationship between wildfire-originated air pollution and cardiovascular health, paving the way for future larger-scale studies in this field.

抽象的在这项补充研究中，我们建议调查气候变化对健康的影响，特别关注补充研究将建立在荒地火灾加剧的空气污染对人类健康的影响的基础上。正在进行的 SAPIA 研究“通过室内空气过滤减缓动脉粥样硬化血栓形成的进展”，旨在评估 HEPA 过滤在减少室内 PM2.5 暴露方面的有效性以及对环境的后续影响 SAPIA 研究将招募并跟踪 52 名年龄在 65-84 岁之间的参与者。岁有缺血性心脏病史，2023-2024 年居住在洛杉矶地区。这项补充研究将扩展 SAPIA 最初的目标，重点调查野火的不利影响暴露并评估住宅 HEPA 过滤的有效性 1) 减少室内 PM2.5 暴露野火事件期间以及 2) 减轻野火对急性心血管结局的不利影响（血压、心率变异性和生物标志物）我们将使用现有的国家和地区野火和空气。污染网络监测，以监测野火季节（五月至九月）的野火事件。在参与者的居住地址使用低成本空气质量传感器来监测室内和室外 PM2.5 通过使用时间序列和扩散模型，我们将验证野火的室内和室外水平。在 HEPA 和非 HEPA 设置中导出 PM2.5 这种方法将使我们能够评估 HEPA 的有效性。 HEPA 过滤可降低室内 PM2.5 浓度一旦确定发生野火事件，参与者将受到影响。告知填写调查问卷并使用预先分配和自行收集的方式收集尿液和血液样本将使用 Withings 血压监测仪远程收集每日血压 (BP) 和心率变异性。和可穿戴 Oura® 戒指这项研究的优点包括使用两臂随机嵌套试验。在正在进行的 SAPIA 交叉试验中，可穿戴数字设备可用于实时健康监测和自我监测收集血液和尿液样本，以便评估野火对健康的急性影响。这项研究的结果将有助于评估 HEPA 过滤作为不良事件预防工具的有效性总之，这项补充研究将有助于了解野火引起的空气污染对健康的影响。对于了解气候变化加剧的野火对人类健康的影响以及潜在的影响具有重要意义 HEPA 过滤通过减少暴露于野火引起的 PM2.5 的健康益处艺术暴露评估方法、实时健康结果监测和生物样本的自我收集，这研究将为了解野火引起的空气污染与空气污染之间的关系提供有价值的见解心血管健康，为该领域未来更大规模的研究铺平道路。