Neuromedical Core (Page 348)

神经医学核心（第348页）

基本信息

批准号：
8195002
负责人：
RONALD J. ELLIS
金额：
$ 35.35万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8195002
关键词：
AIDS neuropathy Acute Address Age Aging Aliquot Alzheimer&apos s Disease Amyloid beta-Protein Anti-Retroviral Agents Area Biological Markers Blood Vessels C-reactive protein CD4 Lymphocyte Count Cerebrovascular Disorders Certification Chronic Chronic Disease Clinical Clinical Research Clinical Trials Cohort Studies Collaborations Community Health Education Comorbidity Consultations Data Data Analyses Deposition Development Diagnostic Discipline Disease Distal Distant Drug Formulations Dyslipidemias Effectiveness Eligibility Determination Enrollment Epidemic Equilibrium Equipment Equipment and Supplies Equipment and supply inventories Evaluation Event Exposure to Extramural Activities Funding Future Genetic Genomics Genotype HIV HIV Infections Head Human Resources Image Immune Immune response Impairment Individual Infection Inflammation Injury Institution Insulin Resistance Interdisciplinary Study International Investigation Laboratories Lead Link Lipids Macrophage Activation Malaria Measurement Measures Medical History Meningitis Mentorship Metabolic Diseases Methods Morbidity - disease rate Nerve Degeneration Nervous system structure Neurobiology Neurocognitive Neurodegenerative Disorders Neurologic Neurovirology Outcome Participant Pathogenesis Pathway interactions Patients Penetration Pharmacology Phenotype Physical Examination Pilot Projects Population Predisposition Prevalence Prevention Process Proteins Publications Recording of previous events Recovery Research Research Infrastructure Research Methodology Research Personnel Research Project Grants Research Support Resources Risk Risk Factors Role Sampling Scientific Evaluation Secure Spinal Puncture Staging Teleconferences Testing Training Translational Research Translations Tuberculosis Update Validation Vascular Diseases Viral Viral Load result Viral Physiology Viral hepatitis Virus Virus Diseases Work age related antiretroviral therapy base clinically relevant cytokine developmental neurobiology disability flexibility immune activation innovation interdisciplinary collaboration meetings mortality nerve injury nervous system disorder neurobehavioral neurobehavioral disorder neuroimaging neurotoxic novel novel strategies pathogen prevent programs public health priorities repository sample collection sensory neuropathy statistics tool development transmission process virus genetics virus host interaction volunteer

项目摘要

Advances in antiretroviral therapy have reduced but not eliminated mortality and neurologic morbidity related to HIV infection. The epidemic has been transformed into a chronic disease in which there is a dynamic equilibrium between mechanisms maintaining viral persistence and host immune strategies that, in combination with antiretroviral therapy, hold viral activity in check. Prospects for eradication or cure are many years or decades away. Looking toward the future, the HNRC perceives four general areas in which research needs are greatest. In the renewal period, the Neuromedical Core (NMC) will therefore develop and mature its research infrastructure to support studies addressing the themes of aging, acute and early HIV infection and clinical relevance. A common thread linking these three themes is genetics-both host and viral. The newly-organized NMC is made up of two cooperative units comprising common resources (equipment, supplies) and staff that interact on a daily basis: a Clinical Research Support Unit (CRSU); and a Laboratory, Pharmacology & Biomarker Unit (LPBU). Together these units will perform evaluations on all HIV+ subjects and HIV- controls, including those enrolled in pilot studies of the Developmental Core. The over-arching objectives of the Neuromedical Core (NMC) are to provide comprehensive clinical and laboratory evaluations, scientific consultation, and mentorship, training, and community education in NeuroAIDS. In the current funding period the NMC facilitated 70 research projects including observational cohort studies, clinical-pathological investigations, imaging studies, clinical trials and international research performed by collaborating investigators at UCSD and many other institutions. By assisting investigators in widely diverging disciplines at all levels of project development, from conceptualization of hypotheses to study implementation, analysis, interpretation and dissemination, the NMC encourages the application of multiple scientific perspectives and stimulates interdisciplinary collaboration and coordination. Through a variety of flexible mechanisms including face-to-face meetings and video teleconferences we will collaborate closely with the Neuroimaging, Neurobehavioral, Neurovirology, Neurobiology, Developmental and International Cores to further the HNRC's transdisciplinary aims.

抗逆转录病毒疗法的进步降低了但没有消除死亡率和神经系统发病率与HIV感染有关。该流行病已转化为一种慢性疾病，其中有一个保持病毒持久性的机制和宿主免疫策略之间的动态平衡，这些策略结合抗逆转录病毒疗法，检查病毒活性。根除或治愈的前景是多年或几十年之遥。着眼于未来，HNRC感知到了四个一般领域研究需求是最大的。因此，在续签期间，神经医学核心（NMC）将发展并成熟其研究基础设施，以支持针对衰老，急性和早期主题的研究 HIV感染和临床相关性。链接这三个主题的一个共同线程是遗传主机和病毒。新组织的NMC由两个合作单元组成，包括共同资源（设备，用品）和每天互动的员工：临床研究支持单位（CRSU）；和实验室，药理学和生物标志物（LPBU）。这些单元将共同执行所有人的评估 HIV+受试者和HIV控制，包括参加发育核心试验研究的受试者。这神经医学核心（NMC）的整个目标是提供全面的临床和实验室评估，科学咨询以及指导，培训和社区教育神经辅助。在当前的资助期内，NMC促进了70个研究项目，包括观察队列研究，临床病理研究，成像研究，临床试验和国际研究由UCSD和许多其他机构的调查人员合作进行。通过协助调查人员在项目开发的各个层面上广泛分歧的学科，假设的概念化以研究实施，分析，解释和传播， NMC鼓励应用多种科学观点并刺激跨学科协作与协调。通过各种灵活的机制，包括面对面的会议和视频电视会议我们将与神经影像，神经行为密切合作，神经病毒学，神经生物学，发展和国际核心，以进一步进一步HNRC 跨学科的目标。