Arizona Alzheimer's Disease Core Center

亚利桑那州阿尔茨海默病核心中心

• 批准号: 8174017
• 负责人: ERIC MICHAEL REIMAN
• 金额: $ 163.2万
• 依托单位: BANNER SUN HEALTH RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8174017
• 关键词: Arizona; Alzheimer; Disease; Core; Center; Arizona; Alzheimer; Disease; Core; Center

This grant application requests five years of renewed support for the Arizona Alzheimer's Disease Core Center (ADCC). The ADCC is intended to optimize the development and use of its Cores, advance the scientific understanding, unusually early detection, and tracking of AD, and the accelerated evaluation of AD modifying and prevention therapies, promote additional organizational investments, and provide a model of statewide collaboration in AD research. The Administrative Core provides the leadership and support needed to optimize the development, interactions, and use of its Cores. It works closely with researchers inside and outside Arizona, the National Alzheimer's Coordinating Center (NACC), and other AD Centers to promote the development and progress of AD-related studies and collaborations. It administers a program for the statewide solicitation, competitive review, and support of pilot studies. It helps solve the challenges and fulfill the opportunities associated with the ADCC's statewide collaborative model and ensures the ADCC's accountability to the NIA. The Clinical Core maintains a large pool of clinically well characterized and annually assessed research subjects for the scientific study of AD and aging, including patients with AD, other dementias, and mild cognitive impairment (MCI); normal controls, most of whom are enrolled in a brain donation program, and a growing number of Latino and Native American research subjects. This Core ensures the comparability and the productive and appropriate use of subjects, DNA, blood samples, and data from its six clinical sites. It also promotes the productive and appropriate scientific use of subjects from its independently supported APOE, Brain and Body Donation, and Clinical Therapeutics Registry Programs. The Data Management and Statistics Core maintains the ADCC's database, helps ensure the quality of data and the protection of subject confidentiality, and provides statistical services and image-analysis resources in a manner that best serves the needs of the statewide ADCC. It works closely with researchers, NACC, and other AD Centers, sharing data in the most productive, timely, and appropriate way. The Neuropathology Core provides neuropathological diagnoses and extremely high-quality brain and body tissues from expired Clinical Core and ancillary program subjects to support research studies in Arizona and around the world, helping to address a critical need in the AD research community. The Education and Information Core provides training, innovative educational and outreach programs, and strategic partnerships to promote the development of AD-related researchers, address needs of professional and family caregivers, provide information about the ADCC, address unmet needs of Arizona's Native American and rapidly growing Latino communities, and assist in the Clinical Core enrollment and study of these understudied groups.

该赠款申请要求对亚利桑那州阿尔茨海默氏病核心中心（ADCC）的五年重新支持。 ADCC旨在优化其核心的开发和使用，提高科学理解，异常的早期检测和对AD的跟踪以及对AD修改和预防疗法的加速评估，促进更多的组织投资，并提供全州范围的AD研究模型。行政核心提供了优化核心发展，互动和使用所需的领导和支持。它与亚利桑那州内外的研究人员，国家阿尔茨海默氏症协调中心（NACC）和其他广告中心紧密合作，以促进与广告相关的研究和合作的发展和进步。它管理一项计划，用于全州招标，竞争性审查和对试点研究的支持。它有助于解决挑战并实现与ADCC全州协作模型相关的机会，并确保ADCC对NIA的问责制。临床核心维持大量临床表征和每年评估的研究对象，以进行AD和衰老的科学研究，包括AD，其他痴呆症和轻度认知障碍（MCI）；正常的控制，大多数人都参加了大脑捐赠计划，以及越来越多的拉丁裔和美国原住民研究对象。该核心确保了来自六个临床部位的受试者，DNA，血液样本和数据的可比性和生产性和适当使用。它还促进了其独立支持的APOE，大脑和身体捐赠以及临床治疗仪式计划中对受试者的富有成效和适当的科学使用。数据管理和统计核心维护ADCC的数据库，有助于确保数据质量和对主题机密性的保护，并以最能满足全州范围ADCC需求的方式提供统计服务和图像分析资源。它与研究人员，NACC和其他广告中心紧密合作，以最有生产力，及时和适当的方式共享数据。神经病理学核心提供神经病理学诊断，并从过期的临床核心和辅助计划主题中提供了极高的大脑和身体组织，以支持亚利桑那州及世界各地的研究，从而帮助满足AD研究社区的关键需求。教育和信息核心提供培训，创新的教育和外展计划以及战略伙伴关系，以促进与广告相关的研究人员的发展，满足专业和家庭护理人员的需求，提供有关ADCC的信息，有关ADCC的信息，满足亚利桑那州原住民的未满足需求以及快速发展的拉丁裔社区的需求，以及在这些被挖掘的研究小组的临床核心注册和研究。