TMJ SYMPHONY Systems-integrated model and mechanisms of patient-centered holistic outcomes and network-supported training and therapy

TMJ SYMPHONY 系统集成模型和以患者为中心的整体结果机制以及网络支持的培训和治疗

• 批准号: 10829112
• 负责人: JANICE S LEE
• 金额: $ 38.44万
• 依托单位: CLEMSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-14 至 2024-09-13
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10829112
• 关键词: Acceleration; Address; Advocacy; Affect; Animal Model; Area; Arthralgia; Artificial Intelligence; Attention; Basic Science; Behavior; Big Data; Biological; Biological Markers; Biological Specimen Banks; Biomechanics; Calibration; Caring; Cell model; Clinical; Clinical Protocols; Clinical Research; Clinical Trials; Clinical Trials Network; Complex; Computer Models; Data; Development; Disease; E-learning; Engineering; Environmental Impact; Etiology; Evidence based treatment; Extramural Activities; Fellowship Program; Fostering; Future; Gender; Goals; Grant; Guidelines; Health; Healthcare; Incubators; Individual; Industry; Information Systems; Infrastructure; Institution; Knowledge; Learning; Machine Learning; Medicine; Methods; Modality; Modeling; Multi-site clinical study; National Institute of Dental and Craniofacial Research; Outcome; Outcome Assessment; Pain; Pain Measurement; Participant; Patients; Perception; Persons; Phase; Phenotype; Population; Registries; Reporting; Research; Research Personnel; Research Training; Resources; Scientist; Site; Specialist; Structure; System; Talents; Techniques; Technology; Telemedicine; Temporomandibular Joint; Temporomandibular Joint Disorders; Therapeutic; Tissue Engineering; Training; Training Support; Training and Education; Translations; United States; United States National Academy of Sciences; Vision; Woman; career development; clinical care; clinical center; clinical phenotype; clinical research site; combinatorial; data repository; data-driven model; design; disease diagnosis; experience; human model; improved outcome; individualized medicine; innovation; interoperability; joint destruction; meetings; men; mind/body; multidisciplinary; multimodal data; multimodality; next generation; novel strategies; optimism; patient oriented; patient population; pre-clinical; prevent; programs; psychosocial; social determinants; stem cell therapy; support network; treatment comparison

PROJECT SUMMARY Approximately 35 million people in the United States are affected by temporomandibular disorders (TMDs) with women 3-8 times more likely to seek treatment compared to men, making it a highly prevalent and expensive healthcare challenge demanding immediate attention. Identifying a specific and treatable cause for TMD is difficult, as it is caused by complex, multifaceted interactions involving biomechanical, biological, and psychosocial components that are poorly understood. Due to these significant gaps in knowledge and the limited integrated mechanistic understanding of TMD, successful long-term therapeutic approaches and patient-specific guidelines to treatment are not available. Our proposal, TMJ SYMPHONY: Systems-integrated model and mechanisms of patient-centered holistic outcomes and network-supported training and therapy, will strategically coalesce a multidisciplinary and multiscale national consortium to decipher the relationships between temporomandibular joint (TMJ) structure-function-pain using computational, cellular, animal and human models. This collective of talented investigators will build upon an existing MPI U01 focused on healthy TMJ structure- function between intramural NIDCR Clinical Researchers and extramural Basic Scientists. It will leverage existing national resources (e.g. RE-JOIN, OPPERA, DOCTRC) to accelerate the translation of discoveries and technologies to directly address TMJ disease diagnosis (e.g., multimodality deep phenotyping, biomarkers), the spectrum of healthy TMJ to preclinical TMJ disease to TMJ degeneration/pain, treatment (e.g., non-invasive holistic/conservative therapies, stem cell therapy, tissue engineered constructs), and improve outcome assessment by understanding patient adaptive capabilities, mind-body-TMJ connection and environmental impact on behavior and perception, and social determinants of TMJ health/disease in a diverse patient population. In this planning phase, we will strategize to make dramatic progress in mechanistic knowledge and identifying combinatorial etiology, while expanding care options, providing evidence-based treatment decisions, and patient-specific treatment modalities over the next decade. What justifies our optimism are our new approaches and techniques already in progress (e.g. chair-side TMJ structure-function-pain assessment toolkit and deep clinical phenotyping, TMJ omics, multi-modality data driven models) and the enthusiasm of clinicians and researchers alike to harness their expertise to identify clinical deliverables to prevent, treat or cure this compelling and complex disorder. The successful completion of the following aims of this planning grant will hone our vision in tackling the TMD IMPACT challenge: (1) Organize, coordinate, and build an integrated multi- disciplinary consortium to mechanistically understand TMJ health and disease, (2) Adapt existing scientific and clinical centers and establish an administrative core which are integrated and focused on TMJ health and disease research, (3) Develop clinical protocols, multi-site clinical research and trials network, and (4) Develop a research training and education program that fosters interdisciplinary career development.

项目概要 在美国，大约有 3500 万人受到颞下颌关节紊乱病 (TMD) 的影响 女性寻求治疗的可能性是男性的 3-8 倍，这使其成为一种非常普遍且昂贵的治疗方法 医疗保健挑战需要立即关注。确定 TMD 的具体且可治疗的原因是 困难，因为它是由复杂的、多方面的相互作用引起的，涉及生物力学、生物学和 人们对社会心理成分知之甚少。由于这些巨大的知识差距和有限的 对 TMD 的综合机制理解、成功的长期治疗方法和患者特异性 没有治疗指南。我们的建议，TMJ SYMPHONY：系统集成模型和 以患者为中心的整体结果和网络支持的培训和治疗的机制，将战略性地 联合一个多学科和多规模的国家联盟来破译之间的关系 使用计算、细胞、动物和人类模型进行颞下颌关节 (TMJ) 结构-功能-疼痛。 这个由才华横溢的研究人员组成的集体将建立在现有的 MPI U01 的基础上，专注于健康的颞下颌关节结构 - 校内 NIDCR 临床研究人员和校外基础科学家之间的职能。它将利用现有 国家资源（例如 RE-JOIN、OPPERA、DOCTRC）以加速发现和成果的转化 直接解决颞下颌关节疾病诊断的技术（例如，多模态深度表型分析、生物标志物）、 健康 TMJ 到临床前 TMJ 疾病到 TMJ 变性/疼痛、治疗（例如非侵入性治疗）的范围 整体/保守疗法、干细胞疗法、组织工程结构），并改善结果 通过了解患者的适应能力、身心-颞下颌关节连接和环境进行评估 对不同患者的行为和感知的影响以及颞下颌关节健康/疾病的社会决定因素 人口。在这个规划阶段，我们将制定战略，在机械知识和 确定组合病因，同时扩大护理选择，提供基于证据的治疗决策， 以及未来十年针对患者的治疗方式。使我们乐观的理由是我们的新 已经在进行中的方法和技术（例如椅旁颞下颌关节结构-功能-疼痛评估工具包 和深度临床表型分析、TMJ 组学、多模态数据驱动模型）以及临床医生的热情 研究人员等利用他们的专业知识来确定临床可交付成果，以预防、治疗或治愈这种疾病 引人注目且复杂的疾病。成功完成本规划赠款的以下目标将 磨练我们应对 TMD IMPACT 挑战的愿景： (1) 组织、协调和建立一个综合性的多方组织 学科联盟，以机械方式了解颞下颌关节健康和疾病，(2) 适应现有的科学和技术 临床中心并建立一个综合的、专注于颞下颌关节健康和疾病的管理核心 研究，(3) 制定临床方案、多地点临床研究和试验网络，以及 (4) 开展研究 促进跨学科职业发展的培训和教育计划。