Columbia University and Northern Plains Partnership for the Superfund Research Program

哥伦比亚大学和北部平原超级基金研究计划合作伙伴关系

基本信息

批准号：
10797697
负责人：
Ana Navas-Acien
金额：
$ 1.08万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-21 至 2027-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10797697
关键词：
Address Adsorption Adult Affect Area Arizona Arsenic Biological Cardiometabolic Disease Cardiovascular Diseases Chemistry Cheyenne Childhood Collaborations Communities Community Outreach Conceptions Congresses Data Data Analyses Diabetes Mellitus Dietary Intervention Distal Elements Ensure Environment Epidemic Epidemiology Etiology Excision Exposure to Fractionation Government Hazardous Waste Sites Health Heart Heart Diseases Household Human Indigenous Institution Intervention Isotopes Joints Knowledge Laboratories Life Light Longitudinal Studies Maintenance Measurement Measures Metal exposure Metals Modeling Molecular Molecular Profiling Monitor Mus Native Americans New Mexico Nutritional status Oxidation-Reduction Pathway interactions Policies Population Prevention Privatization Program Research Project Grants Recycling Research Research Activity Research Design Research Ethics Resolution Risk Reduction Role Rural Rural Community Sampling Science Scientist Signal Recognition Particle Sioux Indians Source South Dakota Specimen Superfund System Techniques Technology Tissue Sample Tissues Toxic effect Training Translational Research Treatment Failure Tribes United States Indian Health Service Universities Uranium Urine Water cardiometabolism citizen science community engagement complex data contaminated drinking water data management disorder prevention drinking water early life exposure effective intervention epigenomics evidence base experience ground water hazardous drinking innovation innovative technologies metabolomics mouse model multiple omics next generation northern Native American northern plains novel photosynthetic bacteria programs remediation stable isotope success superfund site synergism toxic metal transcriptomics tribal community tribal lands urinary wasting water quality water sampling well water

项目摘要

Summary Tribal lands are impacted by more than 15,000 hazardous waste sites and 7,000 abandoned mines that can disrupt the redox chemistry of aquifers and release toxic metals. In collaboration with tribal communities from North/South Dakota, we found that arsenic (As) and uranium (U) affect drinking water in private wells and rural water systems in the Northern Plains. Our data also show that in the 1990s/early 2000s Native Americans from the Northern Plains experienced urinary As and U levels 2.5 to 5 times higher than other US populations, likely contributing to a high burden of cardiovascular disease. Knowledge is needed on current metal exposure levels, sources (local and distal), health effects (concurrent, latent, joint), mechanistic pathways, and effective remediation systems. To address these scientific and technology gaps, we have established the Columbia University Northern Plains Superfund Research Program. This new partnership has five Projects and four Cores and will use systems science, local knowledge, and innovative technology through the following aims: (1) Develop household-level spatial and temporal models of groundwater metal concentrations integrating new measures of water As, U, and redox parameters with USGS and IHS data. These models can identify safe water vs. where mitigation interventions are needed. (2) Trace sources and cycling of metals in water and biological specimens through stable isotope measurements (U, Se) to reveal redox state and inform on local and distal sources of contamination, directly addressing our communities’ concern. (3) Determine latent and concurrent cardiometabolic effects of As and U in humans (Strong Heart As/U Lifelong study, SHAUL), and in human- relevant mouse models. These data will enhance the assessment of causality and the role of early life exposures. (4) Integrate molecular mechanisms of As and U toxicity using multi-omics (epigenomics, metabolomics) in longitudinal studies in humans (SHAUL) and mice. The cross-species comparison can identify robust signatures and mechanisms to help generate intervention strategies. (5) Develop sustainable interventions using light- based, point-of-use water remediation technology for As/U. This system will produce and recycle adsorption media with photosynthetic bacteria and alert residents before treatment failure. The Community Engagement Core will be centrally located in the Northern Plains, contributing to all research activities and local dissemination. The Data Management and Analysis and Administrative Cores will optimize use of the complex data generated while respecting tribal data sovereignty and promoting evidence-based policies and practices to address hazardous toxic metals and contribute to disease prevention. We will train the next generation of scientists in systems science, technology, Indigenous research ethics, and community outreach. The breadth, depth, and innovation of our approaches, the community’s central role, the institutional support, and our experience working together will lay the groundwork for interventions that address key concerns for water quality and human health in communities in the Northern Plains and near abandoned mines and Superfund sites.

概括部落土地受到 15,000 多个危险废物场和 7,000 个废弃矿井的影响，与部落社区合作，破坏含水层的氧化还原化学并释放有毒金属。在北达科他州/南达科他州，我们发现砷 (As) 和铀 (U) 影响私人水井和农村地区的饮用水我们的数据还显示，在 20 世纪 90 年代/2000 年代初期，美洲原住民北部平原的尿砷和尿水平可能比美国其他地区高 2.5 至 5 倍需要了解当前的金属暴露水平，来源（局部和远端）、健康影响（并发、潜在、联合）、机制途径和有效为了解决这些科学和技术差距，我们建立了哥伦比亚这个新的合作伙伴关系大学北部平原超级基金研究计划有五个项目和四个核心。并将利用系统科学、当地知识和创新技术来实现以下目标：(1) 开发家庭层面的地下水金属浓度时空模型，整合新的使用 USGS 和 IHS 数据测量水的 As、U 和氧化还原参数这些模型可以识别安全水。与需要缓解干预措施的情况 (2) 水和生物中金属的痕量来源和循环。通过稳定同位素测量（U、Se）来揭示氧化还原状态并告知局部和远端 (3) 确定潜在和并发 As 和 U 对人类心脏代谢的影响（强心 As/U 终身研究，SHAUL）以及对人类心脏代谢的影响相关的小鼠模型。这些数据将加强对因果关系和早期生命暴露的作用的评估。 (4) 利用多组学（表观基因组学、代谢组学）整合 As 和 U 毒性的分子机制人类（SHAUL）和小鼠的研究跨物种比较可以识别稳健的纵向特征。 (5) 利用光制定可持续的干预措施。该系统将产生并回收吸附剂。含有光合细菌的介质，并在治疗失败之前提醒居民。核心将位于北部平原的中心，为所有研究活动和当地传播做出贡献。数据管理、分析和管理核心将优化生成的复杂数据的使用同时尊重部落数据主权并促进基于证据的政策和做法来解决有害有毒金属并有助于疾病预防我们将培训下一代科学家。系统科学、技术、本土研究伦理和社区推广。我们方法的创新、社区的核心作用、机构支持以及我们的工作经验共同将为解决水质和人类健康关键问题的干预措施奠定基础在北部平原的社区以及废弃矿井和超级基金场地附近。

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Causal mediation for uncausally related mediators in the context of survival analysis.

生存分析背景下非因果相关中介的因果中介。

DOI：
发表时间：
2024-02-18
期刊：
影响因子：
0
作者：
Domingo;Jerolon, Allan;Tellez;Bermudez, Jose D
通讯作者：
Bermudez, Jose D

Association of Water Arsenic With Incident Diabetes in U.S. Adults: The Multi-Ethnic Study of Atherosclerosis and the Strong Heart Study.

水砷与美国成人糖尿病发病率的关联：动脉粥样硬化的多种族研究和强心研究。

DOI：
发表时间：
2024-04-24
期刊：
影响因子：
16.2
作者：
Spaur, Maya;Galvez;Chen, Qixuan;Lombard, Melissa A;Bostick, Benjamin C;Factor;Fretts, Amanda M;Shea, Steven J;Navas;Nigra, Anne E
通讯作者：
Nigra, Anne E

Methods for the Analysis of Multiple Epigenomic Mediators in Environmental Epidemiology.

环境流行病学中多种表观基因组介质的分析方法。