Dietary Support for Healthy Digestion in Crohn's Disease

克罗恩病健康消化的饮食支持

• 批准号: 7923269
• 负责人: Carol S. Brotherton
• 金额: $ 2.8万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-26 至 2012-03-25
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7923269
• 关键词: Abdominal Pain; Adverse drug effect; Area; Cataract; Centers for Disease Control and Prevention (U.S.); Cereals; Chronic; Chronic Disease; Civilization; Clinical; Clinical Trials; Complementary therapies; Crohn' s disease; Development; Diabetes Mellitus; Diagnosis; Diarrhea; Diet; Dietary Fiber; Dietary Intervention; Dietary Supplementation; Digestion; Disease; Disease Clusterings; Dose; Eating; Ecosystem; Etiology; Excision; Fiber; Goals; Health; Health Care Costs; Healthy People 2010; Hemorrhage; Heterogeneity; Hospitalization; Individual; Infection; Inflammation; Inflammatory Bowel Diseases; Instruction; Intake; Intestines; Lead; Life; Molecular; Nurses; Nutritional Study; Operative Surgical Procedures; Osteoporosis; Patient Education; Patients; Persons; Pharmacological Treatment; Physicians; Positioning Attribute; Prednisone; Quality of life; Recurrence; Relapse; Reliance; Reporting; Research; Risk; Role; Solutions; Starch; Supplementation; Symptoms; Testing; Ulcerative Colitis; Visit; Weaning; Weight; Wheat; Wheat Bran; Wound Healing; base; cost; dietary restriction; dietary supplements; disability; disorder prevention; dosage; evidence base; experience; gastrointestinal; improved; prevent; satisfaction; success; sugar

DESCRIPTION (provided by applicant): The primary aim of this study is to investigate the effects of a wheat bran-supplemented/refined sugar-restricted diet plus dietary instruction on the success rate of weaning individuals with Crohn's disease (CD) from their prednisone therapy and returning their bowel function to a level of satisfaction with which they can live. Despite increasing understanding of CD at the cellular and molecular level and advances in pharmacological treatments, a subset of persons with CD continue to relapse with symptoms of abdominal pain, bleeding, and/or diarrhea reappearing while trying to wean from prednisone therapy. Up to 75% of persons with CD require surgical resection of at least one bowel segment when pharmacologic treatments fail. Symptom improvements have been observed clinically in persons with CD who were instructed in the benefits and use of a wheat bran-supplemented/refined sugar-restricted diet to achieve improved bowel function. Demonstrating success of this specific dietary instruction in a clinical trial is the first step in providing nurses with evidence-based patient instructions for persons with CD. The proposed study is in accordance with the goal of Focus Area #19 of Healthy People 2010, "To promote health and reduce chronic disease associated with diet and weight" with specific mention of dietary fiber's critical role in disease prevention and the need to control sugar intake to stay healthy.

描述（由申请人提供）：这项研究的主要目的是调查针对小麦麸皮/精制的糖限制饮食的影响，以及饮食指导，饮食指导对泼尼松疗法中的克罗恩病（CD）的成功率，并将其肠子功能恢复到其能够实现的水平。尽管在细胞和分子水平上对CD的了解越来越多，并且在药理学治疗中的进展，但CD的一部分仍会因腹痛，出血和/或腹泻的症状而继续复发，同时试图从泼尼松疗法中进行断奶。当药物治疗失败时，多达75％的CD患者需要至少一个肠细分的手术切除。在临床上观察到临床上有症状的改善，这些人受到指导的益处和使用小麦麸皮饮食的益处，以提高肠道功能。在临床试验中证明这种特定饮食指导的成功是为护士提供基于证据的患者指导CD的人的第一步。拟议的研究符合2010年Healthy People的焦点区域＃19焦点区域的目标，“促进健康并减少与饮食和体重相关的慢性疾病”，并特别提到饮食纤维在预防疾病预防中的关键作用，以及控制糖摄入量以保持健康的需求。